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  • Result 11-12 of 12
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11.
  • Richards, Stephen, et al. (author)
  • Genome Sequence of the Pea Aphid Acyrthosiphon pisum
  • 2010
  • In: PLoS biology. - : Public Library of Science (PLoS). - 1544-9173 .- 1545-7885. ; 8:2, s. e1000313-
  • Journal article (peer-reviewed)abstract
    • Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.
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12.
  • Sampson, Timothy R., et al. (author)
  • A gut bacterial amyloid promotes α-synuclein aggregation and motor impairment in mice
  • 2020
  • In: eLife. - 2050-084X. ; 9
  • Journal article (peer-reviewed)abstract
    • Amyloids are a class of protein with unique self-aggregation properties, and their aberrant accumulation can lead to cellular dysfunctions associated with neurodegenerative diseases. While genetic and environmental factors can influence amyloid formation, molecular triggers and/or facilitators are not well defined. Growing evidence suggests that non-identical amyloid proteins may accelerate reciprocal amyloid aggregation in a prion-like fashion. While humans encode ~30 amyloidogenic proteins, the gut microbiome also produces functional amyloids. For example, curli are cell surface amyloid proteins abundantly expressed by certain gut bacteria. In mice overexpressing the human amyloid α-synuclein (αSyn), we reveal that colonization with curli-producing Escherichia coli promotes αSyn pathology in the gut and the brain. Curli expression is required for E. coli to exacerbate αSyn-induced behavioral deficits, including intestinal and motor impairments. Purified curli subunits accelerate αSyn aggregation in biochemical assays, while oral treatment of mice with a gut-restricted amyloid inhibitor prevents curli-mediated acceleration of pathology and behavioral abnormalities. We propose that exposure to microbial amyloids in the gastrointestinal tract can accelerate αSyn aggregation and disease in the gut and the brain.
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  • Result 11-12 of 12
Type of publication
journal article (11)
conference paper (1)
Type of content
peer-reviewed (11)
other academic/artistic (1)
Author/Editor
Beguin, Yves (2)
Alonso, Alejandro (1)
Hidvégi, Attila (1)
Gallagher, Jay (1)
Black, John H, 1949 (1)
Ängeby-Möller, Krist ... (1)
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Hultqvist, Klas (1)
Botner, Olga (1)
Finley, Chad (1)
Walck, Christian (1)
Wolf, Martin (1)
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Deoskar, Kunal (1)
O'Sullivan, Erin (1)
Jansson, Matti (1)
Shefali, S. (1)
Glaser, Christian (1)
Sharma, Ankur (1)
Ashton, Peter (1)
Whitehorn, Nathan (1)
Valtonen-Mattila, No ... (1)
Beise, Jakob (1)
Coleman, Alan (1)
Glüsenkamp, Thorsten (1)
Pontén, Axel (1)
Heyer, Nils (1)
Kun, Emma (1)
Abbasi, Rasha (1)
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Adams, Jenni (1)
Agarwalla, Sanjib Ku ... (1)
Aguilar, Juanan (1)
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Amin, Najia Moureen ... (1)
Andeen, Karen (1)
Anton, Gisela (1)
Arguelles, Carlos (1)
Ashida, Yosuke (1)
Athanasiadou, Sofia (1)
Axani, Spencer (1)
Bai, Xinhua (1)
V, Aswathi Balagopal (1)
Baricevic, Moreno (1)
Barwick, Steve (1)
Basu, Vedant (1)
Bay, Ryan (1)
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University
Uppsala University (8)
Chalmers University of Technology (3)
Karolinska Institutet (3)
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Language
English (12)
Research subject (UKÄ/SCB)
Natural sciences (7)
Medical and Health Sciences (6)

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