| 11. |
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| 12. |
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| 13. |
- Björner, Anders, et al.
(author)
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On the shape of Bruhat intervals
- 2009
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In: Annals of Mathematics. - Princeton : Annals of Mathematics. - 0003-486X .- 1939-8980. ; 170:2, s. 799-817
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Journal article (peer-reviewed)abstract
- Let (W, S) be a crystallographic Coxeter group (this includes all finite and affine Weyl groups), and let J subset of S. Let W-J denote the set of minimal coset representatives modulo the parabolic subgroup W-J. For w is an element of W-J, let f(i)(w,J) denote the number of elements of length i below w in Bruhat order on W-J (with notation simplified to f(i)(w) in the case when W-J = W). We show that 0 <= i < j <= l(w)-i implies f(i)(w,J) <= f(j)(w,J). Also, the case of equalities f(i)(w) = f(l(w)-i)(w) for i = 1,..., k is characterized in terms of vanishing of coefficients in the Kazhdan-Lusztig polynomial P-e,P-w (q). We show that if W is finite then the number sequence f(0)(w), f(1)(w),... f(l(w))(w) cannot grow too rapidly. Further, in the finite case, for any given k >= 1 and any w is an element of W of sufficiently great length (with respect to k), we show f(l(w)-k)(w) >= f(l(w)-k+1)(w) >= ... >= f(l(w))(w). The proofs rely mostly on properties of the cohomology of Kac-Moody Schubert varieties, such as the following result: if (X) over bar (w) is a Schubert variety of dimension d = l(w), and lambda = c(1) (L) is an element of H-2 ((X) over bar (w)) is the restriction to (X) over bar (w) of the Chem class of an ample line bundle, then (lambda(k)) . : Hd-k((X) over bar (w)) -> Hd+k((X) over bar (w)) is injective for all k >= 0.
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| 16. |
- Borna, Petter, et al.
(author)
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Self-poisonings with drugs by adolescents in the Lund catchment area
- 2001
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In: Nordic Journal of Psychiatry. - : Informa UK Limited. - 1502-4725 .- 0803-9488. ; 55:5, s. 325-328
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Journal article (peer-reviewed)abstract
- Our objective was to investigate which drugs young people who attempt suicide use in the Lund catchment area-eight municipalities in Skane, southern Sweden. All patients aged up to 18 years admitted to Lund University Hospital after deliberate or probably deliberate self-poisoning from 1 January 1991 until 31 December 1995 were included. Forty-nine (58%) had used a single drug; 20 (24%) had used 3 or more drugs. Fifty-two (61%) used analgesics-paracetamol was used by 38 (45%) and propoxyphene by 17 (20%). Thirty-one (36%) had ingested psychotropics-13 used benzodiazepines, 10 antidepressants, and 8 antipsychotics. Eleven (15%) had used drugs in combination with alcohol. We conclude that it is important to follow changes in self-poisoning patterns, to monitor the effects of preventive work and discover new trends in drug use.
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| 17. |
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| 18. |
- Carlsten, A, et al.
(author)
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Antidepressant medication and suicide in Sweden
- 2001
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In: Pharmacoepidemiology and Drug Safety. - : Wiley. - 1053-8569 .- 1099-1557. ; 10:6, s. 525-530
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To explore a possible temporal association between changes in antidepressant sales and suicide rates in different age groups. METHODS: A time series analysis using a two-slope model to compare suicide rates in Sweden before and after introduction of the selective serotonin reuptake inhibitors, SSRIs. RESULTS: Antidepressant sales increased between 1977-1979 and 1995-1997 in men from 4.2 defined daily doses per 1000 inhabitants and day (DDD/t.i.d) to 21.8 and in women from 8.8 to 42.4. Antidepressant sales were twice as high in the elderly as in the 25-44-year-olds and eight times that in the 15-24-year-olds. During the same time period suicide rates decreased in men from 48.2 to 33.3 per 10(5) inhabitants/year and in women from 20.3 to 13.4. There was significant change in the slope in suicide rates after the introduction of the SSRI, for both men and women, which corresponds to approximately 348 fewer suicides during 1990-1997. Half of these 'saved lives' occurred among young adults. CONCLUSION: We demonstrate a statistically significant change in slope in suicide rates in men and women that coincided with the introduction of the SSRI antidepressants in Sweden. This change preceded the exponential increase in antidepressant sales.
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| 19. |
- Castensson, Staffan, et al.
(author)
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Pharmaceutical Waste: The Patient Role
- 2010. - 1
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In: Green and Sustainable Pharmacy. - Heidelberg Dordrecht London New York : Springer. - 9783642051982 ; , s. 179-200
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Book chapter (other academic/artistic)
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| 20. |
- Cirenajwis, Helena, et al.
(author)
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Molecular stratification of metastatic melanoma using gene expression profiling: prediction of survival outcome and benefit from molecular targeted therapy.
- 2015
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In: Oncotarget. - : Impact Journals, LLC. - 1949-2553. ; 6:14, s. 12297-12309
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Journal article (peer-reviewed)abstract
- Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior studies, we have defined gene expression phenotypes (high-immune, pigmentation, proliferative and normal-like), which are predictive of survival outcome as well as informative of biology. Herein, we employed a population-based metastatic melanoma cohort and external cohorts to determine the prognostic and predictive significance of the gene expression phenotypes. We performed expression profiling on 214 cutaneous melanoma tumors and found an increased risk of developing distant metastases in the pigmentation (HR, 1.9; 95% CI, 1.05-3.28; P=0.03) and proliferative (HR, 2.8; 95% CI, 1.43-5.57; P=0.003) groups as compared to the high-immune response group. Further genetic characterization of melanomas using targeted deep-sequencing revealed similar mutational patterns across these phenotypes. We also used publicly available expression profiling data from melanoma patients treated with targeted or vaccine therapy in order to determine if our signatures predicted therapeutic response. In patients receiving targeted therapy, melanomas resistant to targeted therapy were enriched in the MITF-low proliferative subtype as compared to pre-treatment biopsies (P=0.02). In summary, the melanoma gene expression phenotypes are highly predictive of survival outcome and can further help to discriminate patients responding to targeted therapy.
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