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11.	Skattebol, L, et al. (author) Brain age in multiple sclerosis: a comparison between machine learning and deep learning models 2022 In: MULTIPLE SCLEROSIS JOURNAL. - 1352-4585. ; 28:3_SUPPL, s. 25-26 Conference paper (other academic/artistic)
12.	Skattebol, L, et al. (author) Brain Age in Multiple Sclerosis: A comparison of traditional machine learning and deep learning methods 2022 In: EUROPEAN JOURNAL OF NEUROLOGY. - 1351-5101. ; 29, s. 144-145 Conference paper (other academic/artistic)
13.	Zejlon, C, et al. (author) Structural magnetic resonance imaging findings and histopathological correlations in motor neuron diseases-A systematic review and meta-analysis 2022 In: Frontiers in neurology. - 1664-2295. ; 13, s. 947347- Journal article (other academic/artistic)
14.	Zejlon, C, et al. (author) Structural magnetic resonance imaging findings and histopathological correlations in motor neuron diseases-A systematic review and meta-analysis 2022 In: Frontiers in neurology. - : Frontiers Media SA. - 1664-2295. ; 13, s. 947347- Research review (other academic/artistic)abstract The lack of systematic evidence on neuroimaging findings in motor neuron diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus, we aimed at performing a systematic review and meta-analysis of MRI features in MND including their histopathological correlation.MethodsIn a comprehensive literature search, out of 5941 unique publications, 223 records assessing brain and spinal cord MRI findings in MND were eligible for a qualitative synthesis. 21 records were included in a random effect model meta-analysis.ResultsOur meta-analysis shows that both T2-hyperintensities along the corticospinal tracts (CST) and motor cortex T2*-hypointensitites, also called “motor band sign”, are more prevalent in ALS patients compared to controls [OR 2.21 (95%-CI: 1.40–3.49) and 10.85 (95%-CI: 3.74–31.44), respectively]. These two imaging findings correlate to focal axonal degeneration/myelin pallor or glial iron deposition on histopathology, respectively. Additionally, certain clinical MND phenotypes such as amyotrophic lateral sclerosis (ALS) seem to present with distinct CNS atrophy patterns.ConclusionsAlthough CST T2-hyperintensities and the “motor band sign” are non-specific imaging features, they can be leveraged for diagnostic workup of suspected MND cases, together with certain brain atrophy patterns. Collectively, this study provides high-grade evidence for the usefulness of MRI in the diagnostic workup of suspected MND cases.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42020182682.

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Result 11-14 of 14

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Type of publication: journal article (8); conference paper (5); research review (1)

Type of content: other academic/artistic (9); peer-reviewed (5)

Author/Editor: Piehl, F (9); Granberg, T (9); Ouellette, R (7); Ineichen, BV (7); Hillert, J (6); Olsson, T (6); show more...; Kockum, I. (6); Ferreira, D (6); Westman, E (6); Manouchehrinia, A (6); Stawiarz, L (6); Kaufmann, T (4); Sowa, P (4); Berg-Hansen, P. (4); Brune, S. (4); Beck, D. (3); Nieuwenhuijsen, M. (3); Ineichen, B (3); de Hoogh, K (3); Hoek, G (3); Beelen, R (3); Eeftens, M (3); Meliefste, K (3); Ineichen, A (3); Bellander, T (2); Cyrys, J (2); Beyer, MK (2); Westlye, LT (2); Fratiglioni, Laura (2); Hoffmann, B. (2); Lewandowski, S (2); Katsouyanni, K (2); Harbo, HF (2); Cirach, M. (2); Brunekreef, B (2); Raaschou-Nielsen, O (2); Weinmayr, G (2); Celius, EG (2); Harbo, H (2); de Nazelle, A (2); Molter, A (2); Sugiri, D (2); Tsai, MY (2); Madsen, C (2); Mosler, G (2); Galassi, C. (2); Celius, E (2); Cesaroni, G (2); Zejlon, C (2); Kulcsar, Z (2); show less...

University: Karolinska Institutet (14); Stockholm University (2); Umeå University (1)

Language: English (14)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

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