↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Träfflista för sökning "WFRF:(Kubicek S) "

Search: WFRF:(Kubicek S)

Result 11-12 of 12

Sort/group result

Sort by: Hits per page:

Enumeration	Reference	Cover	Find
11.	Tsiantoulas, D., et al. (author) APRIL limits atherosclerosis by binding to heparan sulfate proteoglycans 2021 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 597, s. 92-96 Journal article (peer-reviewed)abstract Atherosclerotic cardiovascular disease causes heart attacks and strokes, which are the leading causes of mortality worldwide(1). The formation of atherosclerotic plaques is initiated when low-density lipoproteins bind to heparan-sulfate proteoglycans (HSPGs)(2) and become trapped in the subendothelial space of large and medium size arteries, which leads to chronic inflammation and remodelling of the artery wall(2). A proliferation-inducing ligand (APRIL) is a cytokine that binds to HSPGs(3), but the physiology of this interaction is largely unknown. Here we show that genetic ablation or antibody-mediated depletion of APRIL aggravates atherosclerosis in mice. Mechanistically, we demonstrate that APRIL confers atheroprotection by binding to heparan sulfate chains of heparan-sulfate proteoglycan 2 (HSPG2), which limits the retention of low-density lipoproteins, accumulation of macrophages and formation of necrotic cores. Indeed, antibody-mediated depletion of APRIL in mice expressing heparan sulfate-deficient HSPG2 had no effect on the development of atherosclerosis. Treatment with a specific anti-APRIL antibody that promotes the binding of APRIL to HSPGs reduced experimental atherosclerosis. Furthermore, the serum levels of a form of human APRIL protein that binds to HSPGs, which we termed non-canonical APRIL (nc-APRIL), are associated independently of traditional risk factors with long-term cardiovascular mortality in patients with atherosclerosis. Our data reveal properties of APRIL that have broad pathophysiological implications for vascular homeostasis.
12.	Vladimer, GI, et al. (author) Global survey of the immunomodulatory potential of common drugs 2017 In: Nature chemical biology. - : Springer Science and Business Media LLC. - 1552-4469 .- 1552-4450. ; 13:6, s. 681- Journal article (peer-reviewed)

Skapa referenser, mejla, bekava och länka

Permalink

Result 11-12 of 12

Refine your search

Type of publication: journal article (11); conference paper (1)

Type of content: peer-reviewed (10); other academic/artistic (2)

Author/Editor: Bock, C. (2); Li, J. (2); Sundström, Villy (2); Nielsen, Jens B, 196 ... (2); Persson, Petter (2); Lindquist, E. (1); show more...; Liu, B. (1); Nilsson, J. (1); Turner, G (1); Lindemann, S. (1); Sharma, S. (1); Brown, D. (1); Jones, M. (1); Beck, H. (1); James, S. (1); Lucas, S. (1); Meijer, M (1); Edwards, AM (1); Martínez, D. (1); Sjöblom, Gustaf (1); Zhang, YF (1); Ackloo, S (1); Arrowsmith, CH (1); Betz, UAK (1); Edfeldt, K (1); Hillisch, A (1); Leach, AR (1); Morgan, MR (1); Perry, BG (1); Saikatendu, KS (1); Schapira, M (1); Scholten, C (1); Todd, MH (1); Vedadi, M (1); Willson, TM (1); Brown, PJ (1); Dreher, J (1); Egner, U (1); Homan, E (1); Knapp, S (1); Matsui, H (1); Michel, M (1); Owen, DR (1); Sundstrom, M (1); Tredup, C (1); Kalkner, KM (1); Vieira, A (1); de Vries, R P (1); Visser, J (1); Borén, Jan, 1963 (1); show less...

University: Karolinska Institutet (5); Lund University (3); Chalmers University of Technology (2); University of Gothenburg (1); Uppsala University (1)

Language: English (12)

Research subject (UKÄ/SCB): Natural sciences (4); Medical and Health Sciences (2)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

Copyright © LIBRIS - National Library Systems
LIBRIS.kb.se

pil uppåt

Close

Copy and save the link in order to return to this view