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11.	Nystrom, Sofie, et al. (author) Monitoring amyloid formation and maturation in vitro and in vivo using LCO fluorescence in PRION, vol 6, issue , pp 13-13 2012 In: PRION. - : Landes Bioscience. ; , s. 13-13 Conference paper (peer-reviewed)abstract n/a
12.	Nyström, Sofie, et al. (author) Evidence for Age-Dependent in Vivo Conformational Rearrangement within A beta Amyloid Deposits 2013 In: ACS Chemical Biology. - : American Chemical Society. - 1554-8929 .- 1554-8937. ; 8:6, s. 1128-1133 Journal article (peer-reviewed)abstract Deposition of aggregated A beta peptide in the brain is one of the major hallmarks of Alzheimers disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within A beta plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
13.	Speliotes, Elizabeth K., et al. (author) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:11, s. 937-948 Journal article (peer-reviewed)abstract Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 × 10−8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

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Result 11-13 of 13

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Type of publication: journal article (10); other publication (2); conference paper (1)

Type of content: peer-reviewed (11); other academic/artistic (2)

Author/Editor: Lindgren, Per-Eric (4); Renvert, Stefan (3); Renvert, Stefan, 195 ... (2); Persson, G Rutger (2); Hammarström, Per (2); Boeing, Heiner (1); show more...; Khaw, Kay-Tee (1); Nilsson, Peter (1); Tuomi, Tiinamaija (1); Groop, Leif (1); Lorentzon, Mattias, ... (1); Salomaa, Veikko (1); Jula, Antti (1); Perola, Markus (1); Pell, Mikael (1); Viikari, Jorma (1); Heinrich, Joachim (1); Melander, Olle (1); Berndt, Sonja I (1); Wiklund, Fredrik (1); Chanock, Stephen J (1); Ouwehand, Willem H. (1); Soranzo, Nicole (1); Campbell, Harry (1); Rudan, Igor (1); Ohlsson, Claes, 1965 (1); Strachan, David P (1); Deloukas, Panos (1); Lindgren, S (1); Persson, Rutger (1); Ridderstråle, Martin (1); Kågedal, Katarina (1); North, Kari E. (1); Wareham, Nicholas J. (1); Clarke, Robert (1); Hall, Per (1); Kraft, Peter (1); Chatterjee, Nilanjan (1); Sundberg, Cecilia (1); Lindgren, Petter (1); Johansson, Åsa (1); Almgren, Peter (1); Kuusisto, Johanna (1); Isomaa, Bo (1); Laakso, Markku (1); McCarthy, Mark I (1); Pedersen, Oluf (1); Hansen, Torben (1); Ridker, Paul M. (1); Hu, Frank B. (1); show less...

University: Kristianstad University College (5); Linköping University (4); Blekinge Institute of Technology (4); Lund University (3); Malmö University (3); Halmstad University (2); show more...; University of Gothenburg (1); Umeå University (1); Royal Institute of Technology (1); Uppsala University (1); Karolinska Institutet (1); Swedish University of Agricultural Sciences (1); show less...

Language: English (13)

Research subject (UKÄ/SCB): Medical and Health Sciences (6); Natural sciences (4); Agricultural Sciences (1)

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