| 11. |
- Idrisoglu, Alper, et al.
(author)
-
Applied Machine Learning Techniques to Diagnose Voice-Affecting Conditions and Disorders : Systematic Literature Review
- 2023
-
In: Journal of Medical Internet Research. - : JMIR Publications. - 1438-8871. ; 25
-
Research review (peer-reviewed)abstract
- BACKGROUND: Normal voice production depends on the synchronized cooperation of multiple physiological systems, which makes the voice sensitive to changes. Any systematic, neurological, and aerodigestive distortion is prone to affect voice production through reduced cognitive, pulmonary, and muscular functionality. This sensitivity inspired using voice as a biomarker to examine disorders that affect the voice. Technological improvements and emerging machine learning (ML) technologies have enabled possibilities of extracting digital vocal features from the voice for automated diagnosis and monitoring systems. OBJECTIVE: This study aims to summarize a comprehensive view of research on voice-affecting disorders that uses ML techniques for diagnosis and monitoring through voice samples where systematic conditions, nonlaryngeal aerodigestive disorders, and neurological disorders are specifically of interest. METHODS: This systematic literature review (SLR) investigated the state of the art of voice-based diagnostic and monitoring systems with ML technologies, targeting voice-affecting disorders without direct relation to the voice box from the point of view of applied health technology. Through a comprehensive search string, studies published from 2012 to 2022 from the databases Scopus, PubMed, and Web of Science were scanned and collected for assessment. To minimize bias, retrieval of the relevant references in other studies in the field was ensured, and 2 authors assessed the collected studies. Low-quality studies were removed through a quality assessment and relevant data were extracted through summary tables for analysis. The articles were checked for similarities between author groups to prevent cumulative redundancy bias during the screening process, where only 1 article was included from the same author group. RESULTS: In the analysis of the 145 included studies, support vector machines were the most utilized ML technique (51/145, 35.2%), with the most studied disease being Parkinson disease (PD; reported in 87/145, 60%, studies). After 2017, 16 additional voice-affecting disorders were examined, in contrast to the 3 investigated previously. Furthermore, an upsurge in the use of artificial neural network-based architectures was observed after 2017. Almost half of the included studies were published in last 2 years (2021 and 2022). A broad interest from many countries was observed. Notably, nearly one-half (n=75) of the studies relied on 10 distinct data sets, and 11/145 (7.6%) used demographic data as an input for ML models. CONCLUSIONS: This SLR revealed considerable interest across multiple countries in using ML techniques for diagnosing and monitoring voice-affecting disorders, with PD being the most studied disorder. However, the review identified several gaps, including limited and unbalanced data set usage in studies, and a focus on diagnostic test rather than disorder-specific monitoring. Despite the limitations of being constrained by only peer-reviewed publications written in English, the SLR provides valuable insights into the current state of research on ML-based voice-affecting disorder diagnosis and monitoring and highlighting areas to address in future research.
|
|
| 12. |
- Idrisoglu, Alper, et al.
(author)
-
COPDVD : Automated Classification of Chronic Obstructive Pulmonary Disease on a New Developed and Evaluated Voice Dataset
-
Other publication (other academic/artistic)abstract
- AbstractBackground: Chronic obstructive pulmonary disease (COPD) is a severe condition affecting millions worldwide, leading to numerous annual deaths. The absence of significant symptoms in its early stages promotes high underdiagnosis rates for the affected people. Besides pulmonary function failure, another harmful problem of COPD is the systematical effects, e.g., heart failure or voice distortion. However, the systematic effects of COPD might provide valuable information for early detection. In other words, symptoms caused by systematic effects could be helpful to detect the condition in its early stages.Objective: The proposed study aims to: (i) investigate whether the voice features extracted from the vowel "A" phonation carry information that can be predictive of COPD by employing Machine Learning (ML); and (ii) develop a voice dataset based on the evaluation of the features.Methods: Forty-eight participants were recruited from the pool of research clinic visitors at Blekinge Institute of Technology (BTH) in Sweden between January 2022 and May 2023. A dataset consisting of 1246 recordings from 48 participants was gathered. The collection of voice recordings containing the vowel "A" phonation commenced following an information and consent meeting with each participant using the VoiceDiagnistic application. The collected voice data was subjected to silence segment removal, feature extraction of baseline acoustic features, and Mel Frequency Cepstrum Coefficients (MFCC). Sociodemographic data was also collected from the participants. Three ML models were investigated for the binary classification of COPD and healthy controls: Random Forest (RF), Support Vector Machine (SVM), and CatBoost (CB). A nested k-fold cross-validation approach was employed. Additionally, the hyperparameters were optimized using grid-search on each ML model. For best performance assessment, accuracy, F1-score, precision, and recall metrics were computed. Afterward, we further examined the best classifier by utilizing the Area Under the Curve (AUC), Average Precision (AP), and SHapley Additive exPlanations (SHAP) feature importance measures. Results: The classifiers RF, SVM, and CB achieved a maximum accuracy of 77%, 69%, and 78% on the test set and 93%, 78% and 97% on the validation set, respectively. The CB classifier outperformed RF and SVM. After further investigation of the best-performing classifier, CB demonstrated the highest performance, producing an AUC of 82% and AP of 76%. In addition to age and gender, the mean values of baseline acoustic and MFCC features demonstrate high importance and deterministic characteristics for classification performance in both test and validation sets, though in varied order. Conclusion: This study concludes that the vowel "A" recordings contain information that can be captured by the CatBoost classifier with high accuracy for the classification of COPD. Additionally, baseline acoustic and MFCC features, in conjunction with age and gender information, can be employed for classification purposes and benefit healthcare for decision support in COPD diagnosis. Lastly, we believe that the newly developed voice dataset will be a valuable resource to researchers within the domain.
|
|
| 13. |
- Javeed, Ashir, 1989-, et al.
(author)
-
An Intelligent Learning System for Unbiased Prediction of Dementia Based on Autoencoder and Adaboost Ensemble Learning
- 2022
-
In: Life. - : MDPI. - 2075-1729. ; 12:7, s. 1-18
-
Journal article (peer-reviewed)abstract
- Dementia is a neurological condition that primarily affects older adults and there is stillno cure or therapy available to cure it. The symptoms of dementia can appear as early as 10 yearsbefore the beginning of actual diagnosed dementia. Hence, machine learning (ML) researchershave presented several methods for early detection of dementia based on symptoms. However,these techniques suffer from two major flaws. The first issue is the bias of ML models caused byimbalanced classes in the dataset. Past research did not address this issue well and did not takepreventative precautions. Different ML models were developed to illustrate this bias. To alleviate theproblem of bias, we deployed a synthetic minority oversampling technique (SMOTE) to balance thetraining process of the proposed ML model. The second issue is the poor classification accuracy ofML models, which leads to a limited clinical significance. To improve dementia prediction accuracy,we proposed an intelligent learning system that is a hybrid of an autoencoder and adaptive boostmodel. The autoencoder is used to extract relevant features from the feature space and the Adaboostmodel is deployed for the classification of dementia by using an extracted subset of features. Thehyperparameters of the Adaboost model are fine-tuned using a grid search algorithm. Experimentalfindings reveal that the suggested learning system outperforms eleven similar systems which wereproposed in the literature. Furthermore, it was also observed that the proposed learning systemimproves the strength of the conventional Adaboost model by 9.8% and reduces its time complexity.Lastly, the proposed learning system achieved classification accuracy of 90.23%, sensitivity of 98.00%and specificity of 96.65%.
|
|
| 14. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Decision Support System for Predicting Mortality in Cardiac Patients Based on Machine Learning
- 2023
-
In: Applied Sciences. - : MDPI. - 2076-3417. ; 13:8
-
Journal article (peer-reviewed)abstract
- Researchers have proposed several automated diagnostic systems based on machine learning and data mining techniques to predict heart failure. However, researchers have not paid close attention to predicting cardiac patient mortality. We developed a clinical decision support system for predicting mortality in cardiac patients to address this problem. The dataset collected for the experimental purposes of the proposed model consisted of 55 features with a total of 368 samples. We found that the classes in the dataset were highly imbalanced. To avoid the problem of bias in the machine learning model, we used the synthetic minority oversampling technique (SMOTE). After balancing the classes in the dataset, the newly proposed system employed a (Formula presented.) statistical model to rank the features from the dataset. The highest-ranked features were fed into an optimized random forest (RF) model for classification. The hyperparameters of the RF classifier were optimized using a grid search algorithm. The performance of the newly proposed model ((Formula presented.) _RF) was validated using several evaluation measures, including accuracy, sensitivity, specificity, F1 score, and a receiver operating characteristic (ROC) curve. With only 10 features from the dataset, the proposed model (Formula presented.) _RF achieved the highest accuracy of 94.59%. The proposed model (Formula presented.) _RF improved the performance of the standard RF model by 5.5%. Moreover, the proposed model (Formula presented.) _RF was compared with other state-of-the-art machine learning models. The experimental results show that the newly proposed decision support system outperforms the other machine learning systems using the same feature selection module ((Formula presented.)).
|
|
| 15. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Early Prediction of Dementia Using Feature Extraction Battery (FEB) and Optimized Support Vector Machine (SVM) for Classification
- 2023
-
In: Biomedicines. - : MDPI. - 2227-9059. ; 11:2
-
Journal article (peer-reviewed)abstract
- Dementia is a cognitive disorder that mainly targets older adults. At present, dementia has no cure or prevention available. Scientists found that dementia symptoms might emerge as early as ten years before the onset of real disease. As a result, machine learning (ML) scientists developed various techniques for the early prediction of dementia using dementia symptoms. However, these methods have fundamental limitations, such as low accuracy and bias in machine learning (ML) models. To resolve the issue of bias in the proposed ML model, we deployed the adaptive synthetic sampling (ADASYN) technique, and to improve accuracy, we have proposed novel feature extraction techniques, namely, feature extraction battery (FEB) and optimized support vector machine (SVM) using radical basis function (rbf) for the classification of the disease. The hyperparameters of SVM are calibrated by employing the grid search approach. It is evident from the experimental results that the newly pr oposed model (FEB-SVM) improves the dementia prediction accuracy of the conventional SVM by 6%. The proposed model (FEB-SVM) obtained 98.28% accuracy on training data and a testing accuracy of 93.92%. Along with accuracy, the proposed model obtained a precision of 91.80%, recall of 86.59, F1-score of 89.12%, and Matthew’s correlation coefficient (MCC) of 0.4987. Moreover, the newly proposed model (FEB-SVM) outperforms the 12 state-of-the-art ML models that the researchers have recently presented for dementia prediction.
|
|
| 16. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Machine Learning for Dementia Prediction : A Systematic Review and Future Research Directions
- 2023
-
In: Journal of medical systems. - : Springer Nature Switzerland AG. - 0148-5598 .- 1573-689X. ; 47:1
-
Journal article (peer-reviewed)abstract
- Nowadays, Artificial Intelligence (AI) and machine learning (ML) have successfully provided automated solutions to numerous real-world problems. Healthcare is one of the most important research areas for ML researchers, with the aim of developing automated disease prediction systems. One of the disease detection problems that AI and ML researchers have focused on is dementia detection using ML methods. Numerous automated diagnostic systems based on ML techniques for early prediction of dementia have been proposed in the literature. Few systematic literature reviews (SLR) have been conducted for dementia prediction based on ML techniques in the past. However, these SLR focused on a single type of data modality for the detection of dementia. Hence, the purpose of this study is to conduct a comprehensive evaluation of ML-based automated diagnostic systems considering different types of data modalities such as images, clinical-features, and voice data. We collected the research articles from 2011 to 2022 using the keywords dementia, machine learning, feature selection, data modalities, and automated diagnostic systems. The selected articles were critically analyzed and discussed. It was observed that image data driven ML models yields promising results in terms of dementia prediction compared to other data modalities, i.e., clinical feature-based data and voice data. Furthermore, this SLR highlighted the limitations of the previously proposed automated methods for dementia and presented future directions to overcome these limitations.
|
|
| 17. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Optimizing Depression Prediction in Older Adults : A Comparative Study of Feature Extraction and Machine Learning Models
- 2024
-
Conference paper (peer-reviewed)abstract
- Depression emerged as a major public health concern in older adults, and timely prediction of depression has become a difficult problem in medical informatics. The latest studies have attentiveed on feature transformation and selection for better depression prediction. In this study, we assess the performance of various feature extraction algorithms, including principal component analysis (PCA), independent component analysis (ICA), locally linear Embedding (LLE), and t-distributed stochastic neighbor embedding (TSNE). These algorithms are combined with machine learning (ML) classifier algorithms such as Gaussian Naive Bayes (GNB), Logistic Regression (LR), K- nearest-neighbor (KNN), and Decision Tree (DT) to enhance depression prediction. In total, sixteen automated integrated systems are constructed based on the above-mentioned feature extraction methods and ML classifiers. The performance of all of these integrated models is assessed using data from the Swedish National Study on Aging and Care (SNAC). According to the experimental results, the PCA algorithm combined with the Logistic Regression (LR) model provides 89.04% depression classification accuracy. As a result, it is demonstrated that the PCA is a more suitable feature extraction method for depression data than ICA, LLE, and TSNE.
|
|
| 18. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Predicting Dementia Risk Factors Based on Feature Selection and Neural Networks
- 2023
-
In: Computers, Materials and Continua. - : Tech Science Press. - 1546-2218 .- 1546-2226. ; 75:2, s. 2491-2508
-
Journal article (peer-reviewed)abstract
- Dementia is a disorder with high societal impact and severe consequences for its patients who suffer from a progressive cognitive decline that leads to increased morbidity, mortality, and disabilities. Since there is a consensus that dementia is a multifactorial disorder, which portrays changes in the brain of the affected individual as early as 15 years before its onset, prediction models that aim at its early detection and risk identification should consider these characteristics. This study aims at presenting a novel method for ten years prediction of dementia using on multifactorial data, which comprised 75 variables. There are two automated diagnostic systems developed that use genetic algorithms for feature selection, while artificial neural network and deep neural network are used for dementia classification. The proposed model based on genetic algorithm and deep neural network had achieved the best accuracy of 93.36%, sensitivity of 93.15%, specificity of 91.59%, MCC of 0.4788, and performed superior to other 11 machine learning techniques which were presented in the past for dementia prediction. The identified best predictors were: age, past smoking habit, history of infarct, depression, hip fracture, single leg standing test with right leg, score in the physical component summary and history of TIA/RIND. The identification of risk factors is imperative in the dementia research as an effort to prevent or delay its onset.
|
|
| 19. |
- Javeed, Ashir, 1989-, et al.
(author)
-
Predictive Power of XGBoost_BiLSTM Model : A Machine-Learning Approach for Accurate Sleep Apnea Detection Using Electronic Health Data
- 2023
-
In: International Journal of Computational Intelligence Systems. - : Springer Nature. - 1875-6891 .- 1875-6883. ; 16:1
-
Journal article (peer-reviewed)abstract
- Sleep apnea is a common disorder that can cause pauses in breathing and can last from a few seconds to several minutes, as well as shallow breathing or complete cessation of breathing. Obstructive sleep apnea is strongly associated with the risk of developing several heart diseases, including coronary heart disease, heart attack, heart failure, and stroke. In addition, obstructive sleep apnea increases the risk of developing irregular heartbeats (arrhythmias), which can lead to low blood pressure. To prevent these conditions, this study presents a novel machine-learning (ML) model for predicting sleep apnea based on electronic health data that provides accurate predictions and helps in identifying the risk factors that contribute to the development of sleep apnea. The dataset used in the study includes 75 features and 10,765 samples from the Swedish National Study on Aging and Care (SNAC). The proposed model is based on two modules: the XGBoost module assesses the most important features from feature space, while the Bidirectional Long Short-Term Memory Networks (BiLSTM) module classifies the probability of sleep apnea. Using a cross-validation scheme, the proposed XGBoost_BiLSTM algorithm achieves an accuracy of 97% while using only the six most significant features from the dataset. The model’s performance is also compared with conventional long-short-term memory networks (LSTM) and other state-of-the-art ML models. The results of the study suggest that the proposed model improved the diagnosis and treatment of sleep apnea by identifying the risk factors.
|
|
| 20. |
- Kvist, Ola, et al.
(author)
-
A cross-sectional magnetic resonance imaging study of factors influencing growth plate closure in adolescents and young adults
- 2021
-
In: Acta Paediatrica. - : John Wiley & Sons. - 0803-5253 .- 1651-2227. ; 110:4, s. 1249-1256
-
Journal article (peer-reviewed)abstract
- Aim To assess growth plate fusion by magnetic resonance imaging (MRI) and evaluate the correlation with sex, age, pubertal development, physical activity and BMI. Methods Wrist, knee and ankle of 958 healthy subjects aged 14.0-21.5 years old were examined using MRI and graded by two radiologists. Correlations of growth plate fusion score with age, pubertal development, physical activity and BMI were assessed. Results Complete growth plate fusion occurred in 75%, 85%, 97%, 98%, 98% and 90%, 97%, 95%, 97%, 98% (radius, femur, proximal- and distal tibia and calcaneus) in 17-year-old females and 19-year-old males, respectively. Complete fusion occurs approximately 2 years earlier in girls than in boys. Pubertal development correlated with growth plate fusion score (rho = 0.514-0.598 for the different growth plate sites) but regular physical activity did not. BMI also correlated with growth plate fusion (rho = 0.186-0.384). Stratified logistic regression showed increased odds ratio (OR F: 2.65-8.71; M: 1.71-4.03) for growth plate fusion of obese or overweight subects versus normal-weight subjects. Inter-observer agreement was high (Kappa = 0.87-0.94). Conclusion Growth plate fusion can be assessed by MRI; occurs in an ascending order, from the foot to the wrist; and is significantly influenced by sex, pubertal development and BMI, but not by physical activity.
|
|
