| 11. |
- Giannisis,, Andreas, et al.
(author)
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Brain integrity is altered by hepatic APOEε4 in humanized-liver mice
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Other publication (other academic/artistic)abstract
- Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenotype promotes brain injury and neurodegeneration is unknown. Here we investigated the brains of Fah-/-, Rag2-/-, Il2rg-/- mice on the Non-Obese Diabetic (NOD) background (FRGN) with humanized-livers of an AD risk-associated APOE ε4/ε4 versus an APOE ε2/ε3 genotype. Reduced endogenous mouse apoE levels in the brains of APOE ε4/ε4 liver mice were accompanied by various changes in markers of synaptic integrity, neuroinflammation, and insulin signaling. Plasma apoE4 levels were associated with unfavorable changes in several of the assessed markers. These results propose a previously unexplored role of the liver in the APOEε4-associated risk neurodegenerative diseases.
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| 12. |
- Giannisis, Andreas, et al.
(author)
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Brain integrity is altered by hepatic APOE ε4 in humanized-liver mice
- 2022
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In: Molecular Psychiatry. - : Springer Science and Business Media LLC. - 1359-4184 .- 1476-5578. ; 27:8, s. 3533-3543
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Journal article (peer-reviewed)abstract
- Liver-generated plasma apolipoprotein E (apoE) does not enter the brain but nonetheless correlates with Alzheimer’s disease (AD) risk and AD biomarker levels. Carriers of APOEε4, the strongest genetic AD risk factor, exhibit lower plasma apoE and altered brain integrity already at mid-life versus non-APOEε4 carriers. Whether altered plasma liver-derived apoE or specifically an APOEε4 liver phenotype promotes neurodegeneration is unknown. Here we investigated the brains of Fah−/−, Rag2−/−, Il2rg−/− mice on the Non-Obese Diabetic (NOD) background (FRGN) with humanized-livers of an AD risk-associated APOE ε4/ε4 versus an APOE ε2/ε3 genotype. Reduced endogenous mouse apoE levels in the brains of APOE ε4/ε4 liver mice were accompanied by various changes in markers of synaptic integrity, neuroinflammation and insulin signaling. Plasma apoE4 levels were associated with unfavorable changes in several of the assessed markers. These results propose a previously unexplored role of the liver in the APOEε4-associated risk of neurodegenerative disease.
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| 13. |
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| 14. |
- Hansen, Hans Peter, et al.
(author)
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Introduction to part one
- 2016
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In: Routledge advances in research methods. - : Taylor and Francis Group. ; , s. 107-111
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Other publication (other academic/artistic)
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| 15. |
- Hansen, Hans Peter, et al.
(author)
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Preface
- 2016
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Other publication (other academic/artistic)
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| 16. |
- Ingegnoli, Francesca, et al.
(author)
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A comparison between nailfold capillaroscopy patterns in adulthood in juvenile and adult-onset systemic sclerosis: A EUSTAR exploratory study
- 2015
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In: Microvascular Research. - : Elsevier BV. - 1095-9319 .- 0026-2862. ; 102, s. 19-24
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Journal article (peer-reviewed)abstract
- Objective: Qualitative capillaroscopy patterns in juvenile- and adult-onset systemic sclerosis (SSc) were studied in adulthood using data from the EULAR Scleroderma Trials and Research (EUSTAR) database. Methods: Data collected between June 2004 and April 2013 were examined with focus on capillaroscopy. In this retrospective exploratory study, series of patients with juvenile-onset SSc were matched with series of adult-onset SSc having the same gender and autoantibody profile. Results: 30 of 123 patients with juvenile-onset and 2108 of 7133 with adult-onset SSc had data on capillaroscopy. Juvenile-onset SSc showed scleroderma pattern more frequently than adult-onset SSc (93.3% and 88%). The OR was 2.44 and 95% Cl 0.57-10.41. An active scleroderma pattern was present in 58% of juvenile- and 61% of adult-onset SSc. The OR was 0.91 and 95% Cl 0.28-2.93. The late scleroderma pattern was present in 61% of juvenile- and 55.5% of adult-onset SSc. The OR was 1.06 and 95% Cl 0.34-3.56. Conclusion: This is the first exploratory study on the comparison of capillaroscopy between juvenile- and adult-onset SSc in adulthood. Juvenile-onset SSc had an increase prevalence of sderoderma pattern, but a similar distribution of the three patterns was suggested. Further studies are needed to define this issue. (C) 2015 Elsevier Inc. All rights reserved.
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| 17. |
- Lundh, Magdalena, 1979-
(author)
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Domestic Heating with Solar Thermal : Studies of Technology in a Social Context and Social Components in Technical Studies
- 2009
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Doctoral thesis (other academic/artistic)abstract
- Research in solar heating has traditionally focused solely on increasing the system efficiency by improving the technical components. In this thesis the technical methodology and system boundaries are widened to connect the technical aspects with market actors that are highly influential on the implementation of solar technology. The research was focused on how social aspects can be brought into technical studies to improve the understanding of solar heating, and how solar thermal technology can be optimized in a larger energy system. Both heat storage and different system solutions have been investigated. The thesis is built on a number of sub-projects exploring different aspects of solar heating. Improved components and system configurations may result in higher fractional energy savings and thereby make solar energy go from a marginal contribution to be the main energy supplier. Both components and systems are considered in this thesis. The solar heating technology has been shown to work well, also in unique system solutions. Technical possibilities with medium-sized stores for single-family houses and seasonal stores for residential areas are presented. Methods to bring studies of technology and actor studies together are also proposed; domestic hot water use has been modelled based on time-use data, while a multifaceted market situation, in which new system solutions must find their way, has been described by the solar and pellet industries. The complexity of assessing installation and use of a particular heating system in relation to the overall energy system is also discussed. Overall, this thesis shows that successful use of solar heating does not only come down to proper technical solutions, but also depends on the interaction between technology and market actors. A widened perspective, including the social context in which the heating system appears, is then essential. This thesis constitutes a step in that direction.
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| 18. |
- Nielsen, Per Peetz, et al.
(author)
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It is warm outside today: How temperature affects dairy cows' willingness to be on pasture
- 2016
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In: Acta Agriculturae Scandinavica, Section A - Animal Science. - : Informa UK Limited. - 0906-4702 .- 1651-1972. ; 66, s. 215-220
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Journal article (peer-reviewed)abstract
- The effect of Temperature Humidity Index (THI) on dairy cows' willingness to be on pasture was examined. Information for 2 years regarding weather, milk production, and time for voluntarily passing a gate between the barn and pasture of cows milked with an automatic milking system was studied. When the THI exceeded 72 during the day, more cows spent time on pasture compared to when the THI was less than 72 (27.0% vs. 19.2% of cows on pasture, respectively). However, the time of day influenced the proportion of cows on pasture, and when the THI exceeded 72, more cows were on pasture at night and less during the afternoon compared to days when the THI was less than 72. In conclusion, even under Swedish conditions, THI might have an effect on cows' behaviour. However, when the cows have free access to roughage and pasture, an increased THI does not affect milk production.
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| 19. |
- Peetz Nielsen, Per, et al.
(author)
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How Does the Provision of Shade during Grazing Affect Heat Stress Experienced by Dairy Cows in Sweden?
- 2023
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In: Animals. - : Multidisciplinary Digital Publishing Institute (MDPI). - 2076-2615. ; 13:24
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Journal article (peer-reviewed)abstract
- Heat stress in dairy cows can cause an increase in body temperature and respiration rate, and a decreased feed intake leading to reduced production. Dairy cows are better at handling heat when they have access to shade. Therefore, this study aimed to determine the effects of providing shade to high-yielding dairy cattle during the summer in the Swedish climate. Twenty high-yielding Swedish Red dairy cows, held on pasture, were divided into two groups, one with access to shade (S) and one without (NS). Milk production was recorded daily and shade temperature and relative humidity were recorded at 10 min intervals at pasture. A major effect of heat stress was found in cows in early lactation in the NS group. In this group, a high mean temperature two days before and a high THI two days before affected the milk production negatively (p < 0.001), which was the same for the maximum temperature and maximum THI measured on the same day (p < 0.001). Increases in the mean temperature and THI two days before also affected milk production negatively (p < 0.05) for cows in early lactation in the S group, though to a lesser extent. This study suggests that dairy cows in early lactation benefit from access to shade during summer.
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| 20. |
- Roos, Ewa M., et al.
(author)
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Better outcome from arthroscopic partial meniscectomy than skin incisions only? A sham-controlled randomised trial in patients aged 35-55 years with knee pain and an MRI-verified meniscal tear
- 2018
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In: BMJ Open. - : BMJ. - 2044-6055. ; 8:2
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Journal article (peer-reviewed)abstract
- Objective Compare arthroscopic partial meniscectomy to a true sham intervention. Methods Sham-controlled superiority trial performed in three county hospitals in Denmark comparing arthroscopic partial meniscectomy to skin incisions only in patients aged 35-55 years with persistent knee pain and an MRIconfirmed medial meniscus lesion. A computer-generated table of random numbers generated two comparison groups. Participants and outcome assessors were blinded to group allocation. Exclusions were locking knees, highenergy trauma or severe osteoarthritis. Outcomes were collected at baseline, 3 and 24 months. We hypothesised no difference between groups. The primary outcome was the between-group difference in change from baseline to 2 years in the mean score across all five normalised Knee injury and Osteoarthritis Outcome Score (KOOS) subscales (KOOS5). Results Forty-four patients (of the estimated 72) underwent randomisation; 22 in each group. Sixteen participants (36%) were non-blinded and eight participants (36%) from the sham group crossed over to the surgery group prior to the 2-year follow-up. At 2 years, both groups reported clinically relevant improvements (surgery 21.8, skin incisions only 13.6), the mean difference between groups was 8.2 in favour of surgery, which is slightly less than the cut-off of 10 prespecified to represent a clinically relevant difference; judged by the 95% CI (-3.4 to 19.8), a possibility of clinically relevant difference could not be excluded. In total, nine participants experienced 11 adverse events; six in the surgery group and three in the skin-incisions-only group. Conclusion We found greater improvement from arthroscopic partial meniscectomy compared with skin incisions only at 2 years, with the statistical uncertainty of the between-group difference including what could be considered clinically relevant. Because of the study being underpowered, nearly half in the sham group being non-blinded and one-Third crossing over to surgery, the results cannot be generalised to the greater patient population.
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