| 11. |
- Edrén, Johannes, et al.
(author)
-
Modelica and Dymola for education in vehicle dynamics at KTH
- 2009
-
In: Proceedings from 7th Modelica Conference 2009. - : Linköping University Electronic Press. ; , s. 775-783
-
Conference paper (peer-reviewed)abstract
- Dymola and Modelica has been used at KTH Vehicle Dynamics (KTHVD) for research work since 2000, see e.g. [1]. With the Vehicle Dynamics Library (VDL) [2], Modelica has become far more accessible for both researchers and students in the field of vehicle dynamics. Therefore a project aiming at introducing it as a tool in education was initiated in order to evaluate the current state of Dymola and Modelica as tools for wider use in education at the division. The work presented in this paper was realized as a part of a PhD course, where one of the tasks were to design dedicated exercises to illustrate fundamentals of vehicle dynamics for students.
|
|
| 12. |
- Göransson, Jenny, 1978-, et al.
(author)
-
A single molecule array for digital targeted molecular analyses
- 2009
-
In: Nucleic Acids Research. - England : Oxford University Press. - 0305-1048 .- 1362-4962. ; 37:1, s. e7-
-
Journal article (peer-reviewed)abstract
- We present a new random array format together with a decoding scheme for targeted multiplex digital molecular analyses. DNA samples are analyzed using multiplex sets of padlock or selector probes that create circular DNA molecules upon target recognition. The circularized DNA molecules are amplified through rolling-circle amplification (RCA) to generate amplified single molecules (ASMs). A random array is generated by immobilizing all ASMs on a microscopy glass slide. The ASMs are identified and counted through serial hybridizations of small sets of tag probes, according to a combinatorial decoding scheme. We show that random array format permits at least 10 iterations of hybridization, imaging and dehybridization, a process required for the combinatorial decoding scheme. We further investigated the quantitative dynamic range and precision of the random array format. Finally, as a demonstration, the decoding scheme was applied for multiplex quantitative analysis of genomic loci in samples having verified copy-number variations. Of 31 analyzed loci, all but one were correctly identified and responded according to the known copy-number variations. The decoding strategy is generic in that the target can be any biomolecule which has been encoded into a DNA circle via a molecular probing reaction.
|
|
| 13. |
|
|
| 14. |
- Jacobson, Bengt J H, 1962, et al.
(author)
-
Needs for Physical Models and Related Methods for Development of Automated Road Vehicles
- 2019
-
Conference paper (other academic/artistic)abstract
- Road vehicle automation is a trendy topic in research and media. Some automation such as adaptive cruise control and lane keeping is already on market, while totally driverless vehicles in real everyday transportation tasks is still only a vision. How far the products will reach and when can be debated, but any step forward will benefit of, or need, support of modelling formats and related methods. The presentation will explain typical functional/control architecture for vehicles and then focus on development of the partitions Traffic Situation Management and Vehicle Motion Management, assuming that the partition Environment Observation (image processing etc.) comes in place to a certain known maturity. Models will be used with methods for on-line optimization, on-line predictive simulation, virtual off-line verification for right and faulty function, system safety, simulations for legal assessment of long combination vehicles, etc. A goal for novel methods is that, with physical non-causal models, one can avoid some of the enormous amount of verification simulations needed if only input/output (fixed causality) models are used. Examples from heavy vehicles and passenger cars will be given; what is achieved and what are the challenges for next steps.
|
|
| 15. |
- Johnsson, Anders, et al.
(author)
-
Anal cancer in Sweden 2015-2019. Implementation of guidelines, structural changes, national registry and early results
- 2022
-
In: Acta Oncologica. - : Taylor & Francis Group. - 0284-186X .- 1651-226X. ; 61:5, s. 575-582
-
Journal article (peer-reviewed)abstract
- Background Squamous cell cancer of the anus is an uncommon malignancy, usually caused by human papilloma virus (HPV). Chemoradiotherapy (CRT) is the recommended treatment in localized disease with cure rates of 60-80%. Local failures should be considered for salvage surgery. With the purpose of improving and equalizing the anal cancer care in Sweden, a number of actions were taken between 2015 and 2017. The aim of this study was to describe the implementation of guidelines and organizational changes and to present early results from the first 5 years of the Swedish anal cancer registry (SACR). Methods The following were implemented: (1) the first national care program with treatment guidelines, (2) standardized care process, (3) centralization of CRT to four centers and salvage surgery to two centers, (4) weekly national multidisciplinary team meetings where all new cases are discussed, (5) the Swedish anal cancer registry (SACR) was started in 2015. Results The SACR included 912 patients with a diagnosis of anal cancer from 2015 to 2019, reaching a national coverage of 95%. We could show that guidelines issued in 2017 regarding staging procedures and radiotherapy dose modifications were rapidly implemented. At baseline 52% of patients had lymph node metastases and 9% had distant metastases. Out of all patients in the SACR 89% were treated with curative intent, most of them with CRT, after which 92% achieved a local complete remission and the estimated overall 3-year survival was 85%. Conclusions This is the first report from the SACR, demonstrating rapid nation-wide implementation of guidelines and apparently good treatment outcome in patients with anal cancer in Sweden. The SACR will hopefully be a valuable source for future research.
|
|
| 16. |
|
|
| 17. |
|
|
| 18. |
|
|
| 19. |
|
|
| 20. |
|
|
