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| 14. |
- Sjöstedt, Evelina, et al.
(author)
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Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues
- 2018
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In: Journal of Proteome Research. - : American Chemical Society (ACS). - 1535-3893 .- 1535-3907. ; 17:12, s. 4127-4137
-
Journal article (peer-reviewed)abstract
- A large portion of human proteins are referred to as missing proteins, defined as protein-coding genes that lack experimental data on the protein level due to factors such as temporal expression, expression in tissues that are difficult to sample, or they actually do not encode functional proteins. In the present investigation, an integrated omics approach was used for identification and exploration of missing proteins. Transcriptomics data from three different sourcesthe Human Protein Atlas (HPA), the GTEx consortium, and the FANTOM5 consortiumwere used as a starting point to identify genes selectively expressed in specialized tissues. Complementing the analysis with profiling on more specific tissues based on immunohistochemistry allowed for further exploration of cell-type-specific expression patterns. More detailed tissue profiling was performed for >300 genes on complementing tissues. The analysis identified tissue-specific expression of nine proteins previously listed as missing proteins (POU4F1, FRMD1, ARHGEF33, GABRG1, KRTAP2-1, BHLHE22, SPRR4, AVPR1B, and DCLK3), as well as numerous proteins with evidence of existence on the protein level that previously lacked information on spatial resolution and cell-type- specific expression pattern. We here present a comprehensive strategy for identification of missing proteins by combining transcriptomics with antibody-based proteomics. The analyzed proteins provide interesting targets for organ-specific research in health and disease.
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| 15. |
- Spikol, Daniel
(creator_code:cre_t, creator_code:res_t)
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Forskarnas galleri #5 : People have the power: IOTAP on exhibit
- 2018
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Artistic workabstract
- Överallt samlar sensorer data som analyseras för att räkna ut hur man sparar energi, hur mycket insulin som ska injiceras, var den närmaste hyrbilen finns, hur många människor som fortfarande är kvar inne i en brinnande byggnad... Denna snabba spridning av teknik kallas för Sakernas Internet, eller IoT. Människor har makten, eller har vi verkligen det? Hur mycket värderar vi vår integritet? Vilka internetanslutna gadgets hjälper oss att leva ett hälsosamt och hållbart liv - och vilka prylar kommer bara att öka vår stressnivå? När blir användningen missbruk? Utställningen undersöker hur IoT påverkar människor, samhälle och industri. Forskningsprojekt i utställningen: Emergent Configuration for IoT Systems (ECOS+), Smart energy management and security (SEMS), Fair Data, Walk the ward, Dynamic Intelligent Sensor-Intensive Systems (DISS), PELARS-projektet och Busrunner presenteras i "IOTAP-labbet"
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| 16. |
- von Post, Maria, et al.
(author)
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Grön infrastruktur för bevarande av biologisk mångfald
- 2020
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In: ; 7
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Other publication (pop. science, debate, etc.)abstract
- Det svenska arbetet med att skapa en grön infrastruktur syftar till att bevara biologisk mångfald, gynna ekosystemtjänster och stärka ekosystemens resiliens mot exempelvis klimatförändringar. Inom det strategiska forskningsområdet BECC (Biodiversity and Ecosystem services in a Changing Climate) har vi undersökt de teoretiska förutsättningar och praktiska utmaningar som finns när det gäller att använda grön infrastruktur för att ta ett landskapsperspektiv på bevarandearbetet, och för att skapa samverkan mellan olika landskapsaktörer i detta arbete.
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| 17. |
- von Post, Maria, et al.
(author)
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The Swedish green infrastructure policy as a policy assemblage : What does it do for biodiversity conservation?
- 2023
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In: People and Nature. - : Wiley. - 2575-8314. ; 5:2, s. 839-851
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Journal article (peer-reviewed)abstract
- Green infrastructure (GI) is increasingly used in policymaking to promote biodiversity and enhance ecosystem services through the protection, creation, restoration and connection of natural and man-made green areas. The EU Commission adopted in 2013, the concept as a strategy. When member states apply the policy, it is translated into specific bureaucratic and political systems, creating different ‘policy assemblages’ of ideas and institutional features. We analyse the Swedish GI policy to draw conclusions about how it has been assembled in one particular member state and what that particular assemblage will imply for biodiversity conservation. In combination with understanding policies as assemblages, we use the ‘What's the problem represented to be’-approach as method. We show that the Swedish GI policy assemblage consists of a mix of policy ideas developed in Sweden and the EU. Despite the current strong focus on biodiversity conservation, the notion of land's multifunctionality, characterizing the EU strategy and the possibility to conserve biodiversity on land used for purposes other than conservation increasingly influence the Swedish policy as it is formed. Although the policy has the potential to mainstream biodiversity conservation measures across different sectors, based on our analysis of current discourse, its implementation will likely promote GI measures less disruptive to existing land use activities, making its capacity to halt biodiversity loss marginal. Read the free Plain Language Summary for this article on the Journal blog.
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| 18. |
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| 19. |
- Adolfsson, Emelie, et al.
(author)
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A system for remote dosimetry audit of 3D-CRT, IMRT and VMAT based on lithium formate dosimetry
- 2014
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In: Radiotherapy and Oncology. - : Elsevier. - 0167-8140 .- 1879-0887. ; 113:2, s. 279-282
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Journal article (peer-reviewed)abstract
- The aim of this work was to develop and test a remote end-to-end audit system using lithium formate EPR dosimeters. Four clinics were included in a pilot study, absorbed doses determined in the PTV agreed with TPS calculated doses within ±5% for 3D-CRT and ±7% (k=1) for IMRT/VMAT dose plans.
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| 20. |
- Adolfsson, Emelie, et al.
(author)
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Investigation of signal fading in lithium formate EPR dosimeters using a new sensitive method
- 2012
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In: Physics in Medicine and Biology. - : Institute of Physics (IOP). - 0031-9155 .- 1361-6560. ; 57:8, s. 2209-2217
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Journal article (peer-reviewed)abstract
- The aim of this study was to investigate signal fading in lithium formate electron paramagnetic resonance (EPR) dosimeters used for clinical applications in radiotherapy. A new experimental method for determination of signal fading, designed to resolve small changes in signal from slowly decaying unstable radicals, was used. Possible signal fading in lithium formate due to different storage temperatures was also tested. Air humidity was kept at a constant level of 33% throughout the experiments. The conclusion drawn from the investigations was that the EPR signal from lithium formate is stable during at least 1 month after irradiation and is not sensitive to variations in storage temperature andlt;40 degrees C when kept at a relative air humidity of 33%. This makes lithium formate a suitable dosimeter for transfer dosimetry in clinical audits.
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