| 11. |
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| 12. |
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| 13. |
- Meyer, Peter A., et al.
(author)
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Data publication with the structural biology data grid supports live analysis
- 2016
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
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Journal article (peer-reviewed)abstract
- Access to experimental X-ray diffraction image data is fundamental for validation and reproduction of macromolecular models and indispensable for development of structural biology processing methods. Here, we established a diffraction data publication and dissemination system, Structural Biology Data Grid (SBDG; data. sbgrid. org), to preserve primary experimental data sets that support scientific publications. Data sets are accessible to researchers through a community driven data grid, which facilitates global data access. Our analysis of a pilot collection of crystallographic data sets demonstrates that the information archived by SBDG is sufficient to reprocess data to statistics that meet or exceed the quality of the original published structures. SBDG has extended its services to the entire community and is used to develop support for other types of biomedical data sets. It is anticipated that access to the experimental data sets will enhance the paradigm shift in the community towards a much more dynamic body of continuously improving data analysis.
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| 14. |
- Raman, Sudha R., et al.
(author)
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Leveraging electronic health records for clinical research
- 2018
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In: American Heart Journal. - : Elsevier. - 0002-8703 .- 1097-6744. ; 202, s. 13-19
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Journal article (peer-reviewed)abstract
- Electronic health records (EHRs) can be a major tool in the quest to decrease costs and timelines of clinical trial research, generate better evidence for clinical decision making, and advance health care. Over the past decade, EHRs have increasingly offered opportunities to speed up, streamline, and enhance clinical research. EHRs offer a wide range of possible uses in clinical trials, including assisting with prestudy feasibility assessment, patient recruitment, and data capture in care delivery. To fully appreciate these opportunities, health care stakeholders must come together to face critical challenges in leveraging EHR data, including data quality/completeness, information security, stakeholder engagement, and increasing the scale of research infrastructure and related governance. Leaders from academia, government, industry, and professional societies representing patient, provider, researcher, industry, and regulator perspectives convened the Leveraging EHR for Clinical Research Now! Think Tank in Washington, DC (February 18-19, 2016), to identify barriers to using EHRs in clinical research and to generate potential solutions. Think tank members identified a broad range of issues surrounding the use of EHRs in research and proposed a variety of solutions. Recognizing the challenges, the participants identified the urgent need to look more deeply at previous efforts to use these data, share lessons learned, and develop a multidisciplinary agenda for best practices for using EHRs in clinical research. We report the proceedings from this think tank meeting in the following paper. (C) 2018 Elsevier Inc. All rights reserved.
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| 15. |
- Stigebrandt, A., et al.
(author)
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Consequences of artificial deepwater ventilation in the Bornholm Basin for oxygen conditions, cod reproduction and benthic biomass - a model study
- 2015
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In: Ocean Science. - : Copernicus GmbH. - 1812-0784 .- 1812-0792. ; 11:1, s. 93-110
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Journal article (peer-reviewed)abstract
- We develop and use a circulation model to estimate hydrographical and ecological changes in the isolated basin water of the Bornholm Basin. By pumping well-oxygenated so-called winter water to the greatest depth, where it is forced to mix with the resident water, the rate of deepwater density reduction increases as well as the frequency of intrusions of new oxygen-rich deepwater. We show that pumping 1000 m(3) s(-1) should increase the rates of water exchange and oxygen supply by 2.5 and 3 times, respectively. The CRV cod reproduction volume), the volume of water in the isolated basin meeting the requirements for successful cod reproduction (S > 11, O-2 > 2 mL L-1), should every year be greater than 54 km(3), which is an immense improvement, since it has been much less in certain years. Anoxic bottoms should no longer occur in the basin, and hypoxic events will become rare. This should permit extensive colonization of fauna on the earlier periodically anoxic bottoms. Increased biomass of benthic fauna should also mean increased food supply to economically valuable demersal fish like cod and flatfish. In addition, re-oxygenation of the sediments should lead to increased phosphorus retention by the sediments.
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