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Träfflista för sökning "WFRF:(Westermark P.) "

Search: WFRF:(Westermark P.)

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  • Liberta, Falk, et al. (author)
  • Cryo-EM fibril structures from systemic AA amyloidosis reveal the species complementarity of pathological amyloids
  • 2019
  • In: Nature Communications. - : NATURE PUBLISHING GROUP. - 2041-1723. ; 10
  • Journal article (peer-reviewed)abstract
    • Systemic AA amyloidosis is a worldwide occurring protein misfolding disease of humans and animals. It arises from the formation of amyloid fibrils from the acute phase protein serum amyloid A. Here, we report the purification and electron cryo-microscopy analysis of amyloid fibrils from a mouse and a human patient with systemic AA amyloidosis. The obtained resolutions are 3.0 angstrom and 2.7 angstrom for the murine and human fibril, respectively. The two fibrils differ in fundamental properties, such as presence of right-hand or left-hand twisted cross-beta sheets and overall fold of the fibril proteins. Yet, both proteins adopt highly similar beta-arch conformations within the N-terminal similar to 21 residues. Our data demonstrate the importance of the fibril protein N-terminus for the stability of the analyzed amyloid fibril morphologies and suggest strategies of combating this disease by interfering with specific fibril polymorphs.
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  • Result 11-20 of 150
Type of publication
journal article (117)
book chapter (17)
conference paper (13)
other publication (2)
research review (1)
Type of content
peer-reviewed (118)
other academic/artistic (32)
Author/Editor
Westermark, P (109)
Sletten, K (31)
Westermark, GT (19)
Westermark, Gunilla (9)
Johnson, KH (9)
Olsen, KE (9)
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Permert, J (8)
Westermark, Gunilla, ... (8)
Engstrom, U (8)
Andersson, A (7)
Westermark, B (7)
Mucchiano, G (7)
Betsholtz, C (6)
Arnelo, U (6)
Haggqvist, B (6)
Ma, Z (6)
Gustavsson, Å (6)
Gebre-Medhin, S (6)
Larsson, J. (5)
Mulder, H. (5)
Solomon, A (5)
Westermark, G (5)
Westermark, Per (5)
Adrian, TE (5)
Sundler, F (5)
Steiner, DF (5)
Westermark, K (5)
Ahren, B (4)
Sander, B (4)
Boeryd, B. (4)
Persson, P. (4)
Westermark, M (4)
Reidelberger, RD (4)
Lundquist, I (4)
Pekny, M (4)
Westermark, G.T. (4)
Andreo, P (3)
Lunell, S (3)
Karlsson, P (3)
Hartvig, P (3)
Siegbahn, H. (3)
Rosdahl, I (3)
Lundmark, K (3)
Westermark, Gunilla ... (3)
Westermark, A (3)
Sandgren, O (3)
Ma, Zhi (3)
Naslund, J (3)
Eulitz, M (3)
Weiss, DT (3)
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University
Uppsala University (102)
Karolinska Institutet (28)
Linköping University (25)
Umeå University (5)
Stockholm University (3)
Chalmers University of Technology (2)
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Luleå University of Technology (1)
Lund University (1)
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Language
English (149)
Undefined language (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (12)
Natural sciences (2)
Engineering and Technology (1)

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