| 11. |
- Wiberg, Britt, et al.
(author)
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Balanced time perspective : developing empirical profile and exploring its stability over time
- 2017
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In: Time perspective. - London : Palgrave Macmillan. - 9781137601902 - 9781137601919 ; , s. 63-95
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Book chapter (peer-reviewed)abstract
- Balanced time perspective (BTP) is characterized by flexible switching between a person's past, present and future time orientations, depending on situational demands, personal resources, experiences, and social evaluations. The present study aimed to explore the psychological characteristics of people with a BTP profile and attain a deeper understanding of the BTP construct. Seven people with BTP profiles were investigated using in-depth interviews, self-report instruments, and a projective test. By testing the participants on two occasions within an 18-month interval, we investigated the stability of BTP. Analyses showed that participants were aware of the "now" and had a synchronicity between the present and the past, and also between the present and the future. Results indicated a degree of temporal stability in the BTP profile and that people's interpretations and interactions within the surrounding context of events influences their time perspectives.
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| 12. |
- Wiberg, Marie, 1976-, et al.
(author)
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Operationalizing balanced time perspective in a Swedish sample
- 2012
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In: The International Journal of Educational and Psychological Assessment. - : Time Taylor Academic Journals. - 2094-0734. ; 12:1, s. 95-107
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Journal article (peer-reviewed)abstract
- Past research suggests that biases in temporal orientation may have systematic effects ongoal-directed behavior and that physical and mental well-being is associated with balanced time perspective (BTP, Zimbardo and Boyd, 1999). The aim of this study was to examine different operationalizations of the BTP, and to present an alternative proposal in which BTP is measured as a multidimensional, rather than a binary, construct. Two versions of the Zimbardo Time Perspective Inventory (ZTPI) were administered to a sample of 502 individuals. The proposed operationalization shows important advantages in terms of ecological validity of the multidimensional definition, sample independency and possibility to adjust for country differences. Our proposal may also have practical implications both for individuals and groups, e.g. in working teams, psychological counseling, psychotherapy and when recruiting personal forleading positions.
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| 13. |
- Åström, Elisabeth, 1982-, et al.
(author)
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Insights into features of anxiety through multiple aspects of psychological time
- 2014
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In: Journal of Integrative Psychology and Therapeutics. - : Herbert Publications Ltd. - 2054-4723. ; 2
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Journal article (peer-reviewed)abstract
- Background: It is well-recognized that emotions and emotional disorders may alter the experience of time. Yet relatively little is known about different aspects of psychological time in relation to anxiety. The purpose of the present study was to explore several aspects of temporal processing, including time perspective, prospective and retrospective time estimation, in persons with anxiety symptoms.Methods: A total of 110 individuals with varying degrees of anxiety participated in two studies. They were assigned to two groups (anxiety–control) based on their scores on anxiety measurements. Participants also completed an inventory of time perspective and several time estimation tasks which were analyzed on a group-level. Depressive symptoms were assessed and used as a covariate in the second study.Results: Anxiety was significantly associated with Past Negative and Future Negative time perspectives as measured by the Swedish Zimbardo Time Perspective Inventory (S-ZTPI), even when controlling for the effect of depressive symptoms. No other significant differences were found.Conclusion: Exploring time perspective in persons with anxious symptoms may provide important insights into features of anxiety. These findings may offer new ways of conceptualizing anxiety and provide suggestions for treatment strategies.
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| 14. |
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| 15. |
- Bergman, Åke, et al.
(author)
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Science and policy on endocrine disrupters must not be mixed : a reply to a "common sense" intervention by toxicology journal editors
- 2013
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In: Environmental Health. - : BioMed Central (BMC). - 1476-069X. ; 12
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Journal article (peer-reviewed)abstract
- The "common sense" intervention by toxicology journal editors regarding proposed European Union endocrine disrupter regulations ignores scientific evidence and well-established principles of chemical risk assessment. In this commentary, endocrine disrupter experts express their concerns about a recently published, and is in our considered opinion inaccurate and factually incorrect, editorial that has appeared in several journals in toxicology. Some of the shortcomings of the editorial are discussed in detail. We call for a better founded scientific debate which may help to overcome a polarisation of views detrimental to reaching a consensus about scientific foundations for endocrine disrupter regulation in the EU.
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| 16. |
- Bolin, Marie, et al.
(author)
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Prediction of Preeclampsia by Combining Serum Histidine-Rich Glycoprotein and Uterine Artery Doppler
- 2012
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In: American Journal of Hypertension. - : Oxford University Press (OUP). - 0895-7061 .- 1941-7225. ; 25:12, s. 1305-1310
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Journal article (peer-reviewed)abstract
- BackgroundPreeclampsia is associated with both maternal and perinatal morbidity and mortality. Histidine-rich glycoprotein (HRG) is a protein interacting with angiogenesis, coagulation, and inflammatory responses, processes known to be altered in preeclamptic pregnancies. Significantly lower levels of HRG have been demonstrated as early as in the first trimester in women later developing preeclampsia compared with normal pregnancies. The aim of this study was to investigate whether the combination of HRG and uterine artery Doppler ultrasonography can be used as a predictor of preeclampsia.MethodsA total of 175 women were randomly selected from a case-control study; 86 women had an uncomplicated pregnancy and 89 women later developed preeclampsia. Blood samples and pulsatility index (PI) were obtained from both cases and controls in gestational week 14.ResultsHRG levels were significantly lower in women who developed preterm preeclampsia compared with controls, but not for women developing preeclampsia in general. PI was significantly higher in the preeclampsia group compared with controls, especially in preterm preeclampsia. The combination of HRG and PI revealed a sensitivity of 91% and a specificity of 62% for preterm preeclampsia.ConclusionsThe combination of HRG and uterine artery Doppler may predict preterm preeclampsia in early pregnancy.
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| 17. |
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| 18. |
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| 19. |
- Brohlin, Maria, et al.
(author)
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Aging effect on neurotrophic activity of human mesenchymal stem cells
- 2012
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In: PLOS ONE. - San Francisco : Public Library of Science. - 1932-6203. ; 7:9, s. e45052-
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Journal article (peer-reviewed)abstract
- Clinical efficacy of stem cells for nerve repair is likely to be influenced by issues including donor age and in vitro expansion time. We isolated human mesenchymal stem cells (MSC) from bone marrow of young (16–18 years) and old (67–75 years) donors and analyzed their capacity to differentiate and promote neurite outgrowth from dorsal root ganglia (DRG) neurons. Treatment of MSC with growth factors (forskolin, basic fibroblast growth factor, platelet derived growth factor-AA and glial growth factor-2) induced protein expression of the glial cell marker S100 in cultures from young but not old donors. MSC expressed various neurotrophic factor mRNA transcripts. Growth factor treatment enhanced the levels of BDNF and VEGF transcripts with corresponding increases in protein release in both donor cell groups. MSC in co-culture with DRG neurons significantly enhanced total neurite length which, in the case of young but not old donors, was further potentiated by treatment of the MSC with the growth factors. Stem cells from young donors maintained their proliferation rate over a time course of 9 weeks whereas those from the old donors showed increased population doubling times. MSC from young donors, differentiated with growth factors after long-term culture, maintained their ability to enhance neurite outgrowth of DRG. Therefore, MSC isolated from young donors are likely to be a favourable cell source for nerve repair.
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| 20. |
- Brohlin, Maria, et al.
(author)
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Characterisation of human mesenchymal stem cells following differentiation into Schwann cell-like cells
- 2009
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In: Neuroscience research. - : Elsevier BV. - 0168-0102 .- 1872-8111. ; 64:1, s. 41-49
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Journal article (peer-reviewed)abstract
- Cell-based therapies provide a clinically applicable and available alternative to nerve autografts. Our previous studies have characterised rat-derived mesenchymal stem cells (MSC) and here we have investigated the phenotypic, molecular and functional characteristics of human-derived MSC (hMSC) differentiated along a Schwann cell lineage. The hMSC were isolated from healthy human donors and the identity of the undifferentiated hMSC was confirmed by the detection of MSC specific cells surface markers. The hMSC were differentiated along a glial cell lineage using an established cocktail of growth factors including glial growth factor-2. Following differentiation, the hMSC expressed the key Schwann cell (SC) markers at both the transcriptional and translational level. More importantly, we show the functional effect of hMSC on neurite outgrowth using an in vitro co-culture model system with rat-derived primary sensory neurons. The number of DRG sprouting neurites was significantly enhanced in the presence of differentiated hMSC; neurite length and density (branching) were also increased. These results provide evidence that hMSC can undergo molecular, morphological and functional changes to adopt a SC-like behaviour and, therefore, could be suitable as SC substitutes for nerve repair in clinical applications.
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