| 21. |
- De Spiegeleer, Alexandre, et al.
(author)
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Low-frequency oscillatory flow signatures and high-speed flows in the Earth's magnetotail
- 2017
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In: Journal of Geophysical Research - Space Physics. - Washington : American Geophysical Union (AGU). - 2169-9380 .- 2169-9402. ; 122:7, s. 7042-7056
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Journal article (peer-reviewed)abstract
- Using plasma sheet data from Cluster 1 spacecraft from 2001 till 2011, we statistically investigate oscillatory signatures in the plasma bulk flow. These periodic oscillations are compared to high-speed and quiet flows. Periodic oscillations are observed approximately 8% of the time, while high-speed flows and quiet flows are observed around 0.5% and 12% of the time, respectively. We remark that periodic oscillations can roughly occur everywhere for x(gsm) < -10 R-E and |y(gsm)| < 10 RE, while quiet flows mainly occur toward the flanks of this region and toward x = -10 R-E. The relation between the geomagnetic and solar activity and the occurrence of periodic oscillations is investigated and reveal that periodic oscillations occur for most Kp values and solar activity, while quiet flows are more common during low magnetospheric and solar activity. We find that the median oscillation frequency of periodic oscillations is 1.7 mHz and the median duration of the oscillation events is 41 min. We also observe that their associated Poynting vectors show a tendency to be earthward (S-x >= 0). Finally, the distribution of high-speed flows and periodic oscillations as a function of the velocity is investigated and reveals that thresholds lower than 200 km/s should not be used to identify high-speed flows as it could result in misinterpreting a periodic oscillations for a high-speed flow.
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| 22. |
- Del Missier, Fabio, et al.
(author)
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Predictors of Decision Making Across the Adult Life-Span : An Individual-Differences Study
- 2016
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Conference paper (other academic/artistic)abstract
- Age-related decline in complex cognitive tasks has been explained by changes in sensory functioning, processing speed, and working memory. However, there is still no agreement on the relative importance of these factors, and their relative role in decision making has not been investigated. In an individual-difference study on a population-based Swedish sample of adults (N = 563, age range 30-89), we disentangled the contribution of sensory decline, processing speed, and working memory measures to age-related changes in three cognitively-demanding decision-making tasks of the Adult Decision-Making Competence Battery (Resistance to Framing, Applying Decision Rules, Under/Overconfidence). Structural equation modeling showed that working memory is a significant predictor even when the influence of sensory variables, processing speed, and education (as a control for cohort effects) is taken into account. Moreover, the effects of sensory functioning and processing speed on decision making were mediated by working memory. These findings indicate that the age-related decline in complex decision-making tasks may not be entirely explained by changes in lower-level processes, highlighting the functional role of working memory processes.
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| 23. |
- Del Missier, Fabio, et al.
(author)
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Unraveling the Aging Skein : Disentangling Sensory and Cognitive Predictors of Age-related Differences in Decision Making
- 2017
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In: Journal of Behavioral Decision Making. - : Wiley. - 0894-3257 .- 1099-0771. ; 30:1, s. 123-139
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Journal article (peer-reviewed)abstract
- Age-related differences in sensory functioning, processing speed, and working memory have been identified as three significant predictors of the age-related performance decline observed in complex cognitive tasks. Yet, the assessment of their relative predictive capacity and interrelations is still an open issue in decision making and cognitive aging research. Indeed, no previous investigation has examined the relationships of all these three predictors with decision making. In an individual-differences study, we therefore disentangled the relative contribution of sensory functioning, processing speed, and working memory to the prediction of the age-related decline in cognitively demanding judgment and decision-making tasks. Structural equation modeling showed that the age-related decline in working memory plays an important predictive role, even when controlling for sensory functioning, processing speed, and education. Implications for research on decision making and cognitive aging are discussed.
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| 24. |
- Elgland, Mathias, 1987-, et al.
(author)
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beta-Configured clickable [F-18] FDGs as novel F-18-fluoroglycosylation tools for PET
- 2017
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In: New Journal of Chemistry. - : ROYAL SOC CHEMISTRY. - 1144-0546 .- 1369-9261. ; 41:18, s. 10231-10236
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Journal article (peer-reviewed)abstract
- In oncology and neurology the F-18-radiolabeled glucose analogue 2-deoxy-2-[F-18]fluoro-D-glucose ([F-18]FDG) is by far the most commonly employed metabolic imaging agent for positron emission tomography (PET). Herein, we report a novel synthetic route to beta-configured mannopyranoside precursors and a chemoselective F-18-fluoroglycosylation method that employ two b-configured [F-18]FDG derivatives equipped with either a terminal azide or alkyne aglycon respectively, for use as a CuAAC clickable tool set for PET. The b-configured precursors provided the corresponding [F-18]FDGs in a radiochemical yield of 77-88%. Further, the clickability of these [F-18]FDGs was investigated by click coupling to the suitably functionalized Fmoc-protected amino acids, Fmoc-N-(propargyl)-glycine and Fmoc-3-azido-L-alanine, which provided the F-18-fluoroglycosylated amino acid conjugates in radiochemical yields of 75-83%. The F-18-fluoroglycosylated amino acids presented herein constitute a new and interesting class of metabolic PET radiotracers.
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| 25. |
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| 26. |
- Ellström, Patrik, et al.
(author)
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Lipooligosaccharide locus classes and putative virulence genes among chicken and human Campylobacter jejuni isolates
- 2016
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In: BMC Microbiology. - : Springer Science and Business Media LLC. - 1471-2180. ; 16
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Journal article (peer-reviewed)abstract
- Background: Campylobacter cause morbidity and considerable economic loss due to hospitalization and post infectious sequelae such as reactive arthritis, Guillain Barr-and Miller Fischer syndromes. Such sequelae have been linked to C. jejuni harboring sialic acid structures in their lipooligosaccharide (LOS) layer of the cell wall. Poultry is an important source of human Campylobacter infections but little is known about the prevalence of sialylated C. jejuni isolates and the extent of transmission of such isolates to humans. Results: Genotypes of C. jejuni isolates from enteritis patients were compared with those of broiler chicken with pulsed-field gel electrophoresis (PFGE), to study the patterns of LOS biosynthesis genes and other virulence associated genes and to what extent these occur among Campylobacter genotypes found both in humans and chickens. Chicken and human isolates generally had similar distributions of the putative virulence genes and LOS locus classes studied. However, there were significant differences regarding LOS locus class of PFGE types that were overlapping between chicken and human isolates and those that were distinct to each source. Conclusions: The study highlights the prevalence of virulence associated genes among Campylobacter isolates from humans and chickens and suggests possible patterns of transmission between the two species.
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| 27. |
- Eriksson, Axel, et al.
(author)
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Diesel soot aging in urban plumes within hours under cold dark and humid conditions
- 2017
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322.
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Journal article (peer-reviewed)abstract
- Fresh and aged diesel soot particles have different impacts on climate and human health. While fresh diesel soot particles are highly aspherical and non-hygroscopic, aged particles are spherical and hygroscopic. Aging and its effect on water uptake also controls the dispersion of diesel soot in the atmosphere. Understanding the timescales on which diesel soot ages in the atmosphere is thus important, yet knowledge thereof is lacking. We show that under cold, dark and humid conditions the atmospheric transformation from fresh to aged soot occurs on a timescale of less than five hours. Under dry conditions in the laboratory, diesel soot transformation is much less efficient. While photochemistry drives soot aging, our data show it is not always a limiting factor. Field observations together with aerosol process model simulations show that the rapid ambient diesel soot aging in urban plumes is caused by coupled ammonium nitrate formation and water uptake.
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| 28. |
- Franz, D, et al.
(author)
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Towards long-term standardised carbon and greenhouse gas observations for monitoring Europe´s terrestrial ecosystems: a review
- 2018
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In: International Agrophysics. - : Walter de Gruyter GmbH. - 0236-8722 .- 2300-8725. ; 32, s. 439-455
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Journal article (peer-reviewed)abstract
- Research infrastructures play a key role in launching a new generation of integrated long-term, geographically distributed observation programmes designed to monitor climate change, better understand its impacts on global ecosystems, and evaluate possible mitigation and adaptation strategies. The pan-European Integrated Carbon Observation System combines carbon and greenhouse gas (GHG; CO2, CH4, N2O, H2O) observations within the atmosphere, terrestrial ecosystems and oceans. High-precision measurements are obtained using standardised methodologies, are centrally processed and openly available in a traceable and verifiable fashion in combination with detailed metadata. The Integrated Carbon Observation System ecosystem station network aims to sample climate and land-cover variability across Europe. In addition to GHG flux measurements, a large set of complementary data (including management practices, vegetation and soil characteristics) is collected to support the interpretation, spatial upscaling and modelling of observed ecosystem carbon and GHG dynamics. The applied sampling design was developed and formulated in protocols by the scientific community, representing a trade-off between an ideal dataset and practical feasibility. The use of open-access, high-quality and multi-level data products by different user communities is crucial for the Integrated Carbon Observation System in order to achieve its scientific potential and societal value.
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| 29. |
- Frieberg, Otto-Patrik, et al.
(author)
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Development and validation of the self-administered Falun health instrument (SAFHI) using data from health promoted workplaces in Sweden
- 2018
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In: Scandinavian Journal of Public Health. - London : SAGE Publications. - 1403-4948 .- 1651-1905. ; 46:7, s. 735-743
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Journal article (peer-reviewed)abstract
- AIM: The aim of this study was to develop and to validate the self-administered Falun health instrument. An additional aim was to test its applicability in measuring people's lifestyles linked to health.METHODS: In 2002, an instrument was constructed containing questions regarding the hazardous use of alcohol, tobacco, unhealthy diets and insufficient physical activity. A pilot study using the instrument was assessed between 2002 and 2006. In Sweden, it was further expanded and tested during the years 2004-2014 among a total of 1295 people.RESULTS: Face validity was evaluated among colleagues and experts for clarity and completeness resulting in minor adjustments of some questions. With the test-retest method, the self-administered Falun health questionnaire showed a positive and high reproducibility and high compliance. Cronbach's alpha showed a high level of consistency (average 0.86). Factor analysis demonstrated the choice of questions correlated highly to the measured lifestyle.CONCLUSIONS: This study showed that the self-administered Falun health questionnaire is a valid and reliable instrument, useful for detecting individuals at risk of developing diseases that are related to individual choice of lifestyle.
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| 30. |
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