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  • Result 41-50 of 1025803
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41.
  • 3D Lung Models for Regenerating Lung Tissue
  • 2022
  • Editorial collection (peer-reviewed)abstract
    • 3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition.Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field.Key Features A comprehensive summary of advanced 3D lung models written by the experts in the respiratory field Explore novel techniques that can be used to evaluate and improve 3D lung models, including techniques such as 3D printing, bioprinting, and artificial intelligence Explains what extracellular matrix is, the complexity of the lung microenvironment, and why this knowledge is important for creating a functional bioartificial lung
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42.
  • 3rd International Conference on Material Engineering and Advanced Manufacturing Technology, 26–28 April 2019, Shanghai, China
  • 2020
  • Editorial proceedings (peer-reviewed)abstract
    • We are very pleased to present the proceedings of the 3rd International Conference on Material Engineering and Advanced Manufacturing Technology (MEAMT 2019) that was held successfully under the auspices of IASED in Shanghai, China, April 26-28, 2019.The theme of the conference - Material Engineering and Advanced Manufacturing Technology - is of key importance to the science and technology and a sustainable industrial development. This conference promotes valuable contacts between academia and industry and addresses both basic research and the societal/industrial technological needs within Material Engineering and Advanced Manufacturing Technology.In this era of Industry 4.0, we hope that the conference provided applicable data/information, addressed the issues in the societal/industrial transformation, and facilitated exchange within and between academia and industry.We want to express our gratitude to the program chairs and all members of the advisory, publicity, and technical committees for their valuable time and advices. We are grateful to the world renowned scientists who acted as keynote speakers at the conference.After a rigorous review process, where each paper was reviewed by at least two reviewers, high quality papers were accepted for presentation at this conference. We would like to thank all the reviewers for their time, effort, and for completing their assignments on time albeit tight deadlines.Many thanks to the authors for their valuable contributions and to the attendees for their active participation.Finally, a big thank to the organizers who made this conference to yet another unforgettable experience.Nader AsnafiProfessor of Mechanical Engineering, Örebro University, Sweden Editor of the proceedings of MEAMT 2019 One behalf of the conference committee.
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  • 5-HT1A targeting PARCEST agent DO3AM-MPP with potential for receptor imaging : Synthesis, physico-chemical and MR studies
  • 2021
  • In: Bioorganic chemistry. - : Elsevier. - 0045-2068. ; 106
  • Journal article (peer-reviewed)abstract
    • Contrast enhancement in MRI using magnetization or saturation transfer techniques promises better sensitivity, and faster acquisition compared to T-1 or T-2 contrast. This work reports the synthesis and evaluation of 5-HT1A targeted PARACEST MRI contrast agent using 1,4,7,10-tetraazacycloDOdecane-4,7,10-triacetAMide (DO3AM) as the bifunctional chelator, and 5-HT1A-antagonist methoxyphenyl piperazine (MPP) as a targeting unit. The multistep synthesis led to the MPP conjugated DO3AM with 60% yield. CEST-related physicochemical parameters were evaluated after loading DO3AM-MPP with paramagnetic MRI active lanthanides: Gadolinium (Gd-DO3AM-MPP) and Europium (Eu-DO3AM-MPP). Luminescence lifetime measurements with Eu-DO3AM-MPP and computational DFT studies using Gd-DO3AM-MPP revealed the coordination of one water molecule (q = 1.43) with metal-water distance (r(M)-H2O) of 2.7 angstrom and water residence time (tau(m)) of 0.23 ms. The dissociation constant of K-d 62 +/- 0.02 pM as evaluated from fluorescence quenching of 5-HT1A (protein) and docking score of -4.81 in theoretical evaluation reflect the binding potential of the complex Gd-DO3AM-MPP with the receptor 5-HT1A. Insights of the docked pose reflect the importance of NH2 (amide) and aromatic ring in Gd-DO3AM-MPP while interacting with Ser 374 and Phe 370 in the antagonist binding pocket of 5-HT1A. Gd-DO3AM-MPP shows longitudinal relaxivity 5.85 mM(-1)s(-1) with a water residence lifetime of 0.93 ms in hippocampal homogenate containing 5-HT1A. The potentiometric titration of DO3AM-MPP showed strong selectivity for Gd3+ over physiological metal ions such as Zn2+ and Cu2+. The in vitro and in vivo studies confirmed the minimal cytotoxicity and presential binding of Gd-DO3AM-MPP with 5-HT1A receptor in the hippocampus region of the mice. Summarizing, the complex Gd-DO3AM-MPP can have a potential for CEST imaging of 5-HT1A receptors.
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Zetterberg, Henrik, ... (2000)
Blennow, Kaj, 1958 (1754)
aut (1657)
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