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  • Result 61-70 of 172
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  • Kilpelainen, TO, et al. (author)
  • Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
  • 2019
  • In: Nature communications. - London : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 376-
  • Journal article (peer-reviewed)abstract
    • Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.
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  • Liu, JJ, et al. (author)
  • rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk
  • 2016
  • In: Scientific reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6, s. 36874-
  • Journal article (peer-reviewed)abstract
    • NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3′-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936–1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r2 > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969–1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905–1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
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  • Result 61-70 of 172
Type of publication
journal article (162)
conference paper (1)
Type of content
peer-reviewed (136)
other academic/artistic (27)
Author/Editor
Brenner, H (45)
Hall, P (40)
Fasching, PA (39)
Chang-Claude, J (39)
Zheng, W. (38)
Beckmann, MW (38)
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Wang, Q. (37)
Southey, MC (37)
Couch, FJ (37)
Giles, GG (36)
Dunning, AM (36)
Garcia-Closas, M (36)
Hopper, JL (35)
Czene, K (34)
Milne, RL (34)
Cox, A (34)
Benitez, J. (32)
Gudnason, V (32)
Lambrechts, D (32)
Anton-Culver, H (31)
Hamann, U (31)
Mannermaa, A (31)
Jonas, JB (30)
Dennis, J (30)
Lindblom, A (30)
Andrulis, IL (30)
Shu, XO (29)
Ikram, MA (29)
Schmidt, MK (29)
Ekici, AB (29)
Burwinkel, B (29)
Kosma, VM (29)
Lubinski, J (29)
Blomqvist, C (28)
Radice, P (28)
Bojesen, SE (28)
Nordestgaard, BG (27)
Lissowska, J (27)
Jakubowska, A (27)
Brauch, H (26)
Peto, J (26)
Haiman, CA (26)
Devilee, P (26)
Peterlongo, P (25)
Cheng, CY (25)
Wong, TY (25)
Michailidou, K (25)
Bolla, MK (25)
Margolin, S (25)
Winqvist, R (25)
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University
Karolinska Institutet (159)
Lund University (48)
Uppsala University (38)
Umeå University (24)
University of Gothenburg (15)
Linköping University (6)
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Högskolan Dalarna (6)
University of Skövde (5)
Stockholm University (4)
Swedish University of Agricultural Sciences (2)
Stockholm School of Economics (1)
Chalmers University of Technology (1)
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Language
English (172)
Research subject (UKÄ/SCB)
Medical and Health Sciences (62)
Natural sciences (13)
Social Sciences (1)

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