| 1. |
- Abbasi, Rasha, et al.
(author)
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IceCube search for neutrinos from GRB 221009A
- 2023
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In: Proceedings of 38th International Cosmic Ray Conference - PoS(ICRC 2023). - : Sissa Medialab. ; , s. 1511-
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Conference paper (peer-reviewed)abstract
- GRB 221009A is the brightest Gamma Ray Burst (GRB) ever observed. The observed extremelyhigh flux of high and very-high-energy photons provide a unique opportunity to probe the predictedneutrino counterpart to the electromagnetic emission. We have used a variety of methods to searchfor neutrinos in coincidence with the GRB over several time windows during the precursor, promptand afterglow phases of the GRB. MeV scale neutrinos are studied using photo-multiplier ratescalers which are normally used to search for galactic core-collapse supernovae neutrinos. GeVneutrinos are searched starting with DeepCore triggers. These events don’t have directionallocalization, but instead can indicate an excess in the rate of events. 10 GeV - 1 TeV and >TeVneutrinos are searched using traditional neutrino point source methods which take into accountthe direction and time of events with DeepCore and the entire IceCube detector respectively. The>TeV results include both a fast-response analysis conducted by IceCube in real-time with timewindows of T0 − 1 to T0 + 2 hours and T0 ± 1 day around the time of GRB 221009A, as well asan offline analysis with 3 new time windows up to a time window of T0 − 1 to T0 + 14 days, thelongest time period we consider. The combination of observations by IceCube covers 9 ordersof magnitude in neutrino energy, from MeV to PeV, placing upper limits across the range forpredicted neutrino emission.
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| 2. |
- Høg Hansen, Anders
(author)
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Bob Dylan : Kærlighed, Krig og Historie 1961-1967
- 2011
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Book (other academic/artistic)abstract
- Kærlighed, krig og historie er i denne bog ledetråde for en diskussion af Bob Dylans sange, og de sociale og kunstneriske sammenhænge de var en del af, i perioden 1961 til 1967. I bogen diskuteres blandt andet Talkin’ World War III Blues, The Times They Are A-Changin’, The Lonesome Death of Hattie Carroll, Love Minus Zero/No Limit, og Desolation Row. Mange af Dylans sange og optrædener i denne periode udforsker en vidtforgrenet kulturel, mytologisk og historisk baggage som væves ind i samidige sociale spørgsmål. Forfatteren viser, hvordan Dylan kan ses som en af rockmusikkens uregerlige, maskespillende og omskiftelige harlekiner. Dylan hentede inspiration fra Shakespeares vise klovne, fra vandringsmænd og lovløse, vaudevillen, datidens aviser og tv, poeter som Arthur Rimbaud og Robert Frost, og meget andet. Hans universer, som rækker både bagud og fremad, taler til problemer vi kan genkende i dag i det 21. århundrede. Bogen er skrevet til alle, der gerne vil lære og underholdes om, hvordan kærlighed, krig og historie har præget en kunstners udtryk og tekster i 1960erne og hvordan de sociale spørgsmål , tiden og kunsten og Dylan selv lod sig lede af, påvirker os i dag.
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| 3. |
- Castaldo Lundén, Elizabeth, Assistant Professor, 1974-
(author)
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Bob Mackie
- 2023
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In: The Bloomsbury Encyclopedia of Film and Television Costume Design. - London : Bloomsbury Visual Arts. - 9781472521552
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Book chapter (peer-reviewed)
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| 4. |
- Adyari, Bob, et al.
(author)
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Strong impact of micropollutants on prokaryotic communities at the horizontal but not vertical scales in a subtropical reservoir, China
- 2020
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In: Science of the Total Environment. - : Elsevier BV. - 0048-9697 .- 1879-1026. ; 721
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Journal article (peer-reviewed)abstract
- Micropollutants have become of great concern, because of their disrupting effects on the structure and function of microbial communities. However, little is known about the relative importance of trace micropollutants on the aquatic prokaryotic communities as compared to the traditional physico-chemical characteristics, especially at different spatial dimensions. Here, we investigated free-living (FL) and particle-associated (PA) prokaryotic communities in a subtropical water reservoir, China, across seasons at horizontal (surface water) and vertical (depth-profile) scales by using 16S rRNA gene amplicon sequencing. Our results showed that the shared variances of physico-chemicals and micropollutants explained majority of the spatial variations in prokaryotic communities, suggesting a strong joint effect of the two abiotic categories on reservoir prokaryotic communities. Micropollutants appeared to exert strong independent influence on the core sub-communities (i.e., abundant and wide-spread taxa) than on the satellite (i.e., less abundant and narrow-range taxa) counterparts. The pure effect of micropollutants on both core and satellite sub-communities from FL and PA fractions was similar to 1.5 folds greater than that of physico-chemical factors at the horizontal scale, whereas an opposite effect was observed at the vertical scale. Moreover, eight micropollutants including anti-fungal agents, antibiotics, bisphenol analogues, stimulant and UV-filter were identified as the major disrupting compounds with strong associations with core taxa of typical freshwater prokaryotes. Altogether, we concluded that the ecological disrupting effects of micropollutants on prokaryotic communities may vary along horizontal and vertical dimensions in freshwater ecosystems.
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| 5. |
- Appleyard, Bob, et al.
(author)
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Best Practice Guideline: Transportation of People Seated in Wheelchairs, Version 2.21.
- 2010
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In: [Host publication title missing].
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Conference paper (peer-reviewed)abstract
- Summary, key points: Transport considerations ought to be factored into the initial phase of the wheelchair & seating assessment process. Manufacturers of wheelchairs and seating systems should make information relating to the safe transportation of their products readily available - and easy to understand. With the desire to provide the safest possible transport environment for wheelchair-seated passengers, and other vehicle occupants, all stakeholders must engage in a multi-disciplinary approach to ensuring transport safety; involving the wheelchair user with their families, carers, equipment prescribers, and transport providers*. A proven crashworthy wheelchair, used in conjunction with a proven wheelchair tie-down and occupant restraint system (WTORS), is fundamental to the provision of safe transport for both people who remain seated in their wheelchairs in a motor vehicle and other vehicle occupants. Exceptions exist on certain high-mass, low-speed urban public transport vehicles, where the likelihood of a crash situation and the severity thereof are low. Powered and manual wheelchairs offer a large variety of seated postures through their tilt, recline, and other mechanisms. Guidelines ought to be given by manufacturers with respect to use of these mechanisms during transport. The combination of a crashworthy seating system, that accommodates the proper fit of the occupant restraints, and a crashworthy wheelchair serve to indicate to the prescriber that the risks of equipment failure when exposed to crash conditions during transport have been reduced as far as reasonably possible. To minimise injury risk for wheelchair occupants, prescribers shall seek to ensure that the means of attachment of the seating system to the wheelchair is suitable for use in transport. It is imperative that the manufacturer’s instructions for use and fitting instructions for seating systems are carefully adhered to. Due to the individual nature of disability, prescribers may at times be faced with the need to work beyond manufacturers’ recommendations for the use of systems in order to maximise medical benefits, and to address the postural and functional needs of a wheelchair user. In such cases a risk management process ought to be followed, and transport providers should have a working comprehension of the relevant documented risk assessment process and understand the subsequent Risk/Benefit analysis. When properly used, a WTORS allows the wheelchair to be well secured to the vehicle floor and the passenger in the wheelchair to benefit from a properly fitted seatbelt system. Wheelchair manufacturers should highlight in their pre-sale literature any special requirements relating to the use of their wheelchair with WTORS. This information should include the configuration of the representative wheelchair, which was subjected to crash testing, so that informed decisions can be made with respect to wheelchair selection & configuration. Prescriber awareness of the type of transport environment and the facilities available to assist vehicle entry and egress is highly beneficial in the risk analysis process.
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| 6. |
- Argiropoulos, Bob, et al.
(author)
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Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.
- 2008
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In: Experimental hematology. - : Elsevier BV. - 0301-472X. ; 36:7, s. 845-59
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Journal article (peer-reviewed)abstract
- OBJECTIVE: MEIS1, a HOX cofactor, collaborates with multiple HOX and NUP98-HOX fusion proteins to accelerate the onset of acute myeloid leukemia (AML) through largely unknown molecular mechanisms. MATERIALS AND METHODS: To further resolve these mechanisms, we conducted a structure-function analysis of MEIS1 and gene-expression profiling, in the context of NUP98-HOXD13 (ND13) leukemogenesis. RESULTS: We show, in a murine bone marrow transplantation model, that the PBX-interaction domain, the homeodomain, and the C-terminal domain of MEIS1, are all required for leukemogenic collaboration with ND13. In contrast, the N-terminal domain of MEIS1 is dispensable for collaboration with ND13, but is required for Flt3 upregulation, indicating additional roles for MEIS1 in induction of leukemia independent of alterations in Flt3 expression. Gene-expression profiling of a cloned ND13 preleukemic cell line transduced with wild-type or Meis1 mutant forms revealed deregulation of multiple genes, including a set not previously implicated as MEIS1 targets. Chromatin immunoprecipitation revealed the in vivo occupancy of MEIS1 on regulatory sequences of Trib2, Flt3, Dlk1, Ccl3, Ccl4, Pf4, and Rgs1. Furthermore, engineered overexpression of Trib2 complements ND13 to induce AML while Ccl3 potentiates the repopulating ability of ND13. CONCLUSION: This study shows that Meis1-induced leukemogenesis with ND13 can occur in the absence of Flt3 upregulation and reveals the existence of other pathways activated by MEIS1 to promote leukemia.
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| 7. |
- Argiropoulos, Bob, et al.
(author)
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Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.
- 2010
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In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 115:20, s. 4071-82
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Journal article (peer-reviewed)abstract
- MEIS1 is a three-amino acid loop extension class homeodomain-containing homeobox (HOX) cofactor that plays key roles in normal hematopoiesis and leukemogenesis. Expression of Meis1 is rate-limiting in MLL-associated leukemias and potently interacts with Hox and NUP98-HOX genes in leukemic transformation to promote self-renewal and proliferation of hematopoietic progenitors. The oncogenicity of MEIS1 has been linked to its transcriptional activation properties. To further reveal the pathways triggered by Meis1, we assessed the function of a novel engineered fusion form of Meis1, M33-MEIS1, designed to confer transcriptional repression to Meis1 target genes that are otherwise up-regulated in normal and malignant hematopoiesis. Retroviral overexpression of M33-Meis1 resulted in the rapid and complete eradication of M33-Meis1-transduced normal and leukemic cells in vivo. Cell-cycle analysis showed that M33-Meis1 impeded the progression of cells from G(1)-to-S phase, which correlated with significant reduction of cyclin D3 levels and the inhibition of retinoblastoma (pRb) hyperphosphorylation. We identified cyclin D3 as a direct downstream target of MEIS1 and M33-MEIS1 and showed that the G(1)-phase accumulation and growth suppression induced by M33-Meis1 was partially relieved by overexpression of cyclin D3. This study provides strong evidence linking the growth-promoting activities of Meis1 to the cyclin D-pRb cell-cycle control pathway.
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| 8. |
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| 9. |
- Briscoe, Bob, et al.
(author)
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Reducing Internet Latency : A Survey of Techniques and Their Merits
- 2016
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In: IEEE Communications Surveys and Tutorials. - : IEEE. - 1553-877X. ; 18:3, s. 2149-2196
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Journal article (peer-reviewed)abstract
- Latency is increasingly becoming a performance bottleneck for Internet Protocol (IP) networks, but historically, networks have been designed with aims of maximizing throughput and utilization. This paper offers a broad survey of techniques aimed at tackling latency in the literature up to August 2014, as well as their merits. A goal of this work is to be able to quantify and compare the merits of the different Internet latency reducing techniques, contrasting their gains in delay reduction versus the pain required to implement and deploy them. We found that classifying techniques according to the sources of delay they alleviate provided the best insight into the following issues: 1) The structural arrangement of a network, such as placement of servers and suboptimal routes, can contribute significantly to latency; 2) each interaction between communicating endpoints adds a Round Trip Time (RTT) to latency, particularly significant for short flows; 3) in addition to base propagation delay, several sources of delay accumulate along transmission paths, today intermittently dominated by queuing delays; 4) it takes time to sense and use available capacity, with overuse inflicting latency on other flows sharing the capacity; and 5) within end systems, delay sources include operating system buffering, head-of-line blocking, and hardware interaction. No single source of delay dominates in all cases, and many of these sources are spasmodic and highly variable. Solutions addressing these sources often both reduce the overall latency and make it more predictable.
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| 10. |
- Carter, Bob, et al.
(author)
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Nothing gets done and no one knows why : PCS and workplace control of lean in HM revenue and customs
- 2012
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In: Industrial relations journal. - : Wiley. - 0019-8692 .- 1468-2338. ; 43:5, s. 416-432
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Journal article (peer-reviewed)abstract
- This article examines the willingness and capacity of public sector unions to mobilise action against changes in the labour process in order to maintain some measure of control at the point of production. Taking as an instance an extended dispute in Her Majesty's Revenue and Customs over the introduction and impact of Lean processes, it marshals evidence gathered from documentary sources, branch representatives and national lay full-time officers to engage with the notion of a trade union bureaucracy. In taking a union with a left-wing leadership and a section with 80 per cent membership with an expressed willingness to escalate industrial action, the article tests Hyman's 1979 contention that, rather than a concentration on a bureaucratic caste, a much better explanation for conservatism centres on the nature of social relations within the union that encompass a wider layer of representatives.
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