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Träfflista för sökning "((WFRF:(Barbosa TD)) srt2:(2015-2019)) srt2:(2019) "

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  • Borg, ML, et al. (author)
  • Modified UCN2 Peptide Acts as an Insulin Sensitizer in Skeletal Muscle of Obese Mice
  • 2019
  • In: Diabetes. - : American Diabetes Association. - 1939-327X .- 0012-1797. ; 68:7, s. 1403-1414
  • Journal article (peer-reviewed)abstract
    • The neuropeptide urocortin 2 (UCN2) and its receptor corticotropin-releasing hormone receptor 2 (CRHR2) are highly expressed in skeletal muscle and play a role in regulating energy balance and glucose metabolism. We investigated a modified UCN2 peptide as a potential therapeutic agent for the treatment of obesity and insulin resistance, with a specific focus on skeletal muscle. High-fat–fed mice (C57BL/6J) were injected daily with a PEGylated UCN2 peptide (compound A) at 0.3 mg/kg subcutaneously for 14 days. Compound A reduced body weight, food intake, whole-body fat mass, and intramuscular triglycerides compared with vehicle-treated controls. Furthermore, whole-body glucose tolerance was improved by compound A treatment, with increased insulin-stimulated Akt phosphorylation at Ser473 and Thr308 in skeletal muscle, concomitant with increased glucose transport into extensor digitorum longus and gastrocnemius muscle. Mechanistically, this is linked to a direct effect on skeletal muscle because ex vivo exposure of soleus muscle from chow-fed lean mice to compound A increased glucose transport and insulin signaling. Moreover, exposure of GLUT4-Myc–labeled L6 myoblasts to compound A increased GLUT4 trafficking. Our results demonstrate that modified UCN2 peptides may be efficacious in the treatment of type 2 diabetes by acting as an insulin sensitizer in skeletal muscle.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Krook, A (2)
Zierath, JR (2)
Barbosa, TD (2)
Wade, M. (1)
Chibalin, AV (1)
Barres, R (1)
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Massart, J. (1)
Alm, PS (1)
Ryan, A (1)
Bauer, S (1)
Borg, ML (1)
Schonke, M (1)
Guo, LL (1)
Alsina-Fernandez, J (1)
Miles, R (1)
Coskun, T (1)
O'Farrell, E (1)
Niemeier, EM (1)
Karlsson, HK (1)
Brozinick, JT (1)
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University
Karolinska Institutet (2)
Language
English (2)
Year
2019 (2)

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