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Träfflista för sökning "(AMNE:(MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences)) srt2:(1990-1999) srt2:(1992)"

Search: (AMNE:(MEDICAL AND HEALTH SCIENCES Basic Medicine Pharmaceutical Sciences)) srt2:(1990-1999) > (1992)

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1.	Anderberg, Eva Karin (author) Studies on the dissolution of fine particulate practically insoluble drugs and on the effect of surface active enhancers on gastrointestinal absorption of hydrophilic drugs 1992 Doctoral thesis (other academic/artistic)
2.	Angberg, Maria (author) Evaluation of isothermal heat-conduction microcalorimetry in pharmaceutical stability studies 1992 Doctoral thesis (other academic/artistic)
3.	Danielson, Kiki (author) Mechanistic studies on skeletal malformations caused by phenytoin, vasodilating drugs and selenium 1992 Doctoral thesis (other academic/artistic)
4.	Ekblom, Marianne (author) Pharmacokinetic and pharmacodynamic studies of morphine and morphine-3-glucuronide in rats : including validation and application of the microdialysis technique and time dependency of antinociceptive effects 1992 Doctoral thesis (other academic/artistic)
5.	Encarnación Dimayuga, Rosalba (author) Pharmacognostical studies of natural resources from Baja California Sur, Mexico 1992 Doctoral thesis (other academic/artistic)
6.	Fornstedt, Torgny (author) Distortions of analyte peaks due to large system peaks in ion-pair adsorption chromatography 1992 Doctoral thesis (other academic/artistic)
7.	Jönsson, Karin, et al. (author) Evaluation of the degradation of desamino1,D-arginine8-vasopressin by nasal mucosa. 1992 In: Acta Endocrinologica. - : Oxford University Press (OUP). - 0001-5598 .- 0804-4643 .- 1479-683X. ; 127:1, s. 27-32 Journal article (peer-reviewed)abstract The nasal route is a convenient and simple way to administer peptides to humans. Absorption of the drug, however, requires passage of the substance through the nasal mucosa. This is a possible site of enzymatic degradation of the peptide. It is shown that rabbit nasal mucosa homogenates rapidly degrade the synthetic anti-diuretic hormone analogue desamino1,D-arginine8-vasopressin in vitro. The metabolite formed has been identified as des-(amino,arginine8,glycineamide9)-vasopressin, which is stable under the prevalent in vitro incubation conditions. It is proposed that this process is catalyzed by intracellular post-proline cleavage enzyme. Reversed phase chromatography in combination with immunological detection has been used to study the possible presence of this metabolite in the circulation after intranasal administration to humans. The metabolite des-(amino,arginine8,glycineamide9)-vasopressin could not be detected in plasma following intranasal administration, possibly indicating a paracellular absorption of desamino1,D-arginine8-vasopressin or absence of this enzymatic activity in humans.
8.	Lennernäs, Hans (author) Intestinal absorption characteristics of three model drugs 1992 Doctoral thesis (other academic/artistic)
9.	Litzén, Anne (author) Asymmetrical flow field-flow fractionation 1992 Doctoral thesis (other academic/artistic)
10.	Sjökvist Saers, Eva, et al. (author) Studies on solid dispersions for fast release and dissolution of drugs with low aqueous solubility 1992 Doctoral thesis (other academic/artistic)

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Result 1-10 of 14

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Type of publication: doctoral thesis (13); journal article (1)

Type of content: other academic/artistic (13); peer-reviewed (1)

Author/Editor: Lennernäs, Hans (1); Jönsson, Karin (1); Fornstedt, Torgny (1); Wikberg, Martin (1); Ohlin, Mats (1); Anderberg, Eva Karin (1); show more...; Angberg, Maria (1); Westerberg, Marie (1); Danielson, Kiki (1); Ekblom, Marianne (1); Encarnación Dimayuga ... (1); Alfredsson, Karin (1); söderberg-ahlm, Chri ... (1); Critchley, Helen (1); Broeders, Anja (1); Litzén, Anne (1); Stefansson, Morgan (1); Sjökvist Saers, Eva (1); Stjärnkvist, Peter (1); Vallgårda, Jerk (1); show less...

University: Uppsala University (13); Lund University (1)

Language: English (14)

Research subject (UKÄ/SCB): Medical and Health Sciences (14)

Year: 1992 (14)Undo refine

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