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Träfflista för sökning "(L773:0896 6273 OR L773:1097 4199) srt2:(2020-2024) srt2:(2020)"

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1.	Beets, Isabel, et al. (author) Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression 2020 In: Neuron. - : Elsevier. - 0896-6273 .- 1097-4199. ; 105:1, s. 106-121 Journal article (peer-reviewed)abstract The extent to which behavior is shaped by experience varies between individuals. Genetic differences contribute to this variation, but the neural mechanisms are not understood. Here, we dissect natural variation in the behavioral flexibility of two Caenorhabditis elegans wild strains. In one strain, a memory of exposure to 21% O2 suppresses CO2-evoked locomotory arousal; in the other, CO2 evokes arousal regardless of previous O2 experience. We map that variation to a polymorphic dendritic scaffold protein, ARCP-1, expressed in sensory neurons. ARCP-1 binds the Ca2+-dependent phosphodiesterase PDE-1 and co-localizes PDE-1 with molecular sensors for CO2 at dendritic ends. Reducing ARCP-1 or PDE-1 activity promotes CO2 escape by altering neuropeptide expression in the BAG CO2 sensors. Variation in ARCP-1 alters behavioral plasticity in multiple paradigms. Our findings are reminiscent of genetic accommodation, an evolutionary process by which phenotypic flexibility in response to environmental variation is reset by genetic change.
2.	Henneberger, C, et al. (author) LTP Induction Boosts Glutamate Spillover by Driving Withdrawal of Perisynaptic Astroglia 2020 In: Neuron. - : Elsevier BV. - 1097-4199 .- 0896-6273. ; 108:5, s. 919- Journal article (peer-reviewed)
3.	Kupari, J, et al. (author) Pricking into Autonomic Reflex Pathways by Electrical Acupuncture 2020 In: Neuron. - : Elsevier BV. - 1097-4199 .- 0896-6273. ; 108:3, s. 395-397 Journal article (peer-reviewed)
4.	Roussarie, JP, et al. (author) Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis 2020 In: Neuron. - : Elsevier BV. - 1097-4199 .- 0896-6273. ; 107:5, s. 821- Journal article (peer-reviewed)
5.	Song, JR, et al. (author) Multiple Rhythm-Generating Circuits Act in Tandem with Pacemaker Properties to Control the Start and Speed of Locomotion 2020 In: Neuron. - : Elsevier BV. - 1097-4199 .- 0896-6273. ; 105:6, s. 1048- Journal article (peer-reviewed)
6.	Zetterberg, Henrik, 1973, et al. (author) Blood Biomarkers: Democratizing Alzheimer's Diagnostics 2020 In: Neuron. - : Elsevier BV. - 0896-6273. ; 106:6, s. 881-883 Journal article (peer-reviewed)abstract Currently available biomarkers for Alzheimer's disease are of limited availability due to high costs and perceived invasiveness. New studies reveal that Alzheimer's pathologies now can be reliably quantified in vivo using regular blood tests. Currently available biomarkers for Alzheimer's disease are of limited availability due to high costs and perceived invasiveness. New studies reveal that Alzheimer's pathologies now can be reliably quantified in vivo using regular blood tests. © 2020 Elsevier Inc.

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Result 1-6 of 6

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Type of publication: journal article (6)

Type of content: peer-reviewed (6)

Author/Editor: Blennow, Kaj, 1958 (1); Zetterberg, Henrik, ... (1); Ernfors, P (1); Nagelhus, EA (1); Ottersen, OP (1); Wang, W. (1); show more...; Greengard, P (1); Flajolet, M (1); Ampatzis, K (1); Song, JR (1); Ausborn, J (1); El Manira, A (1); Anders, S. (1); Dolinski, K. (1); Hof, PR (1); Heintz, N (1); Beets, Isabel (1); Zhang, Gaotian (1); Fenk, Lorenz A. (1); Chen, Changchun (1); Nelson, Geoffrey M. (1); Félix, Marie-Anne (1); de Bono, Mario (1); Bertuzzi, M (1); Picton, LD (1); Pallucchi, I (1); Heiman, M (1); Troyanskaya, OG (1); Panatier, A. (1); Kupari, J (1); Roussarie, JP (1); Rodriguez-Rodriguez, ... (1); Schmidt, EF (1); Henneberger, C (1); Bard, L (1); Reynolds, JP (1); Kopach, O (1); Medvedev, NI (1); Minge, D (1); Herde, MK (1); Kraev, I (1); Heller, JP (1); Rama, S (1); Zheng, KY (1); Jensen, TP (1); Sanchez-Romero, I (1); Jackson, CJ (1); Janovjak, H (1); Oliet, SHR (1); Stewart, MG (1); show less...

University: Karolinska Institutet (4); University of Gothenburg (1); Umeå University (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2020 (6)Undo refine

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