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1.	Festari, Cristina, et al. (author) European consensus for the diagnosis of MCI and mild dementia : Preparatory phase 2023 In: Alzheimer's and Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:5, s. 1729-1741 Journal article (peer-reviewed)abstract Introduction: Etiological diagnosis of neurocognitive disorders of middle-old age relies on biomarkers, although evidence for their rational use is incomplete. A European task force is defining a diagnostic workflow where expert experience fills evidence gaps for biomarker validity and prioritization. We report methodology and preliminary results. Methods: Using a Delphi consensus method supported by a systematic literature review, 22 delegates from 11 relevant scientific societies defined workflow assumptions. Results: We extracted diagnostic accuracy figures from literature on the use of biomarkers in the diagnosis of main forms of neurocognitive disorders. Supported by this evidence, panelists defined clinical setting (specialist outpatient service), application stage (MCI-mild dementia), and detailed pre-assessment screening (clinical-neuropsychological evaluations, brain imaging, and blood tests). Discussion: The Delphi consensus on these assumptions set the stage for the development of the first pan-European workflow for biomarkers’ use in the etiological diagnosis of middle-old age neurocognitive disorders at MCI-mild dementia stages. Highlights: Rational use of biomarkers in neurocognitive disorders lacks consensus in Europe. A consensus of experts will define a workflow for the rational use of biomarkers. The diagnostic workflow will be patient-centered and based on clinical presentation. The workflow will be updated as new evidence accrues.
2.	Samuelsson, Jessica, et al. (author) Associations between dietary patterns and dementia-related neuroimaging markers 2023 In: Alzheimers & Dementia. - : Wiley. - 1552-5260 .- 1552-5279. ; 19:10, s. 4629-4640 Journal article (peer-reviewed)abstract BACKGROUNDThe exploration of associations between dietary patterns and dementia-related neuroimaging markers can provide insights on food combinations that may impact brain integrity. METHODSData were derived from the Swedish Gothenburg H70 Birth Cohort Study (n = 610). Three dietary patterns were obtained using principal component analysis. Magnetic resonance imaging markers included cortical thickness, an Alzheimer's disease (AD) signature score, small vessel disease, and white matter microstructural integrity. Adjusted linear/ordinal regression analyses were performed. RESULTSA high-protein and alcohol dietary pattern was negatively associated with cortical thickness in the whole brain (Beta: -0.011; 95% confidence interval [CI]: -0.018 to -0.003), and with an Alzheimer's disease cortical thickness signature score (Beta: -0.013; 95% CI: -0.024 to -0.001). A positive association was found between a Mediterranean-like dietary pattern and white matter microstructural integrity (Beta: 0.078; 95% CI: 0.002-0.154). No associations were found with a Western-like dietary pattern. DISCUSSIONDietary patterns may impact brain integrity through neurodegenerative and vascular pathways. HighlightsCertain dietary patterns were associated with dementia-related neuroimaging markers.A Mediterranean dietary pattern was positively associated with white matter microstructure.A high-protein and alcohol pattern was negatively associated with cortical thickness.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Otto, Markus (1); Boada, Mercè (1); Aarsland, Dag (1); Westman, E (1); Skoog, Ingmar, 1954 (1); Vandenbulcke, Mathie ... (1); show more...; Hansson, Oskar (1); Ahlner, Felicia, 198 ... (1); Kern, Silke (1); Samuelsson, Jessica (1); Zettergren, Anna, 19 ... (1); Scheltens, Philip (1); van der Flier, Wiesj ... (1); Pereira, Joana B. (1); Yousry, Tarek (1); Frisoni, Giovanni B. (1); Borroni, Barbara (1); Perret-Liaudet, Arma ... (1); Babiloni, Claudio (1); Shams, S. (1); Garibotto, Valentina (1); Jessen, Frank (1); Dubois, Bruno (1); Marseglia, Anna (1); Nobili, Flavio (1); Morbelli, Silvia (1); Massa, Federico (1); Festari, Cristina (1); Rothenberg, E. (1); Georges, Jean (1); Lindberg, O (1); Verhey, Frans (1); O'Brien, John T. (1); Froelich, Lutz (1); Pizzini, Francesca B (1); Vanninen, Ritva (1); Vernooij, Meike W. (1); Cappa, Stefano (1); Ritchie, Craig W (1); Cotta Ramusino, Matt ... (1); Gandolfo, Federica (1); Nicolosi, Valentina (1); Orini, Stefania (1); Agosta, Federica (1); Frederiksen, Kristia ... (1); Haliassos, Alexander (1); Kamondi, Anita (1); Kessels, Roy P.C. (1); show less...

University: Lund University (2); Karolinska Institutet (2); University of Gothenburg (1); Kristianstad University College (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2023 (2)Undo refine

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