| 1. |
- Fabijan, Aleksander, et al.
(author)
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- 2015
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In: Software Business. - Cham : Springer. ; , s. 139-153
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Conference paper (peer-reviewed)abstract
- In many companies, product management struggles in getting accurate customer feedback. Often, validation and confirmation of functionality with customers takes place only after the product has been deployed, and there are no mechanisms that help product managers to continuously learn from customers. Although there are techniques available for collecting customer feedback, these are typically not applied as part of a continuous feedback loop. As a result, the selection and prioritization of features becomes far from optimal, and product deviates from what the customers need. In this paper, we present a literature review of currently recognized techniques for collecting customer feedback. We develop a model in which we categorize the techniques according to their characteristics. The purpose of this literature review is to provide an overview of current software engineering research in this area and to better understand the different techniques that are used for collecting customer feedback.
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| 2. |
- Aad, G., et al.
(author)
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- 2010
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swepub:Mat__t
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| 3. |
- Aad, G., et al.
(author)
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- 2013
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In: Journal of Instrumentation. - 1748-0221. ; 8
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Journal article (peer-reviewed)
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| 4. |
- Aad, G., et al.
(author)
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- 2011
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swepub:Mat__t (peer-reviewed)
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| 5. |
- Aad, G., et al.
(author)
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- 2015
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Journal article (peer-reviewed)
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| 6. |
- Adamik, Peter, et al.
(author)
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Barrier crossing in small avian migrants : individual tracking reveals prolonged nocturnal flights into the day as a common migratory strategy
- 2016
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 6
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Journal article (peer-reviewed)abstract
- Over decades it has been unclear how individual migratory songbirds cross large ecological barriers such as seas or deserts. By deploying light-level geolocators on four songbird species weighing only about 12 g, we found that these otherwise mainly nocturnal migrants seem to regularly extend their nocturnal flights into the day when crossing the Sahara Desert and the Mediterranean Sea. The proportion of the proposed diurnally flying birds gradually declined over the day with similar landing patterns in autumn and spring. The prolonged flights were slightly more frequent in spring than in autumn, suggesting tighter migratory schedules when returning to breeding sites. Often we found several patterns for barrier crossing for the same individual in autumn compared to the spring journey. As only a small proportion of the birds flew strictly during the night and even some individuals might have flown non-stop, we suggest that prolonged endurance flights are not an exception even in small migratory species. We emphasise an individual’s ability to perform both diurnal and nocturnal migration when facing the challenge of crossing a large ecological barrier to successfully complete a migratory journey.
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| 7. |
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| 8. |
- Mullier, Geoffrey A., et al.
(author)
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Measurement of the cross-sections of the electroweak and total production of a Zγ pair in association with two jets in pp collisions at √ˆšs=13TeV with the ATLAS detector
- 2023
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In: Physics Letters B. - : Elsevier. - 0370-2693 .- 1873-2445. ; 846
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Journal article (peer-reviewed)abstract
- This Letter presents the measurement of the fiducial and differential cross-sections of the electroweakproduction of a Z γ pair in association with two jets. The analysis uses 140 fb−1 of LHC proton–protoncollision data taken at √s=13 TeV recorded by the ATLAS detector during the years 2015–2018. Eventswith a Z boson candidate decaying into either an e+e− or μ+μ− pair, a photon and two jets areselected. The electroweak component is extracted by requiring a large dijet invariant mass and by usingthe information about the centrality of the system and is measured with an observed and expectedsignificance well above five standard deviations. The fiducial pp → Z γ j j cross-section for the electroweakproduction is measured to be 3.6 ± 0.5 fb. The total fiducial cross-section that also includes contributionswhere the jets arise from strong interactions is measured to be 16.8+2.0−1.8 fb. The results are consistentwith the Standard Model predictions. Differential cross-sections are also measured using the same eventsand are compared with parton-shower Monte Carlo simulations. Good agreement is observed betweendata and predictions.
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| 9. |
- Abdalla, Amir Osman
(author)
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Immunological and clinical long-term effects of idiotype vaccination in multiple myeloma patients
- 2007
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Doctoral thesis (other academic/artistic)abstract
- In spite of the promising results shown by new anti-myeloma agents, multiple myeloma (MM) remains incurable and additional therapy to overcome the inevitable disease recurrence is greatly needed. Immunotherapy is currently under evaluation as a novel alternative or complementary therapy in many cancer types. The idiotype (Id) protein is a unique myeloma specific antigen that may be targeted in therapeutic vaccination. This thesis presents and discusses results of ld vaccination in early stage MM patients and underscores the immunological and clinical effects of the vaccine. In the first study we analyzed the time kinetics of cytokine genes expression (IL-2, IL-5, IFNgamma, GM-CSF and TNF-alpha) and granzyme B in healthy donors to be used as supplementary markers for antigen-specific I lymphocytes in subsequent studies. For most cytokines, the time for maximum accumulation seemed to be obtained after 4 to 8 h of activation. However, a sustained high level could be noticed for up to 24 h. Granzyme B gene expression showed a continuous gradual increase and late maximal accumulation (48-72 h). We concluded that cytokine genes expression would better be measured after 4-8 h of specific stimulation, but also up to 24 h of stimulation is acceptable. Granzyme B may preferentially be measured after 48 h of activation. In the second study, Id-specific T cell responses were evaluated by multiple read-out systems in 18 patients vaccinated with the ld together with either interleukin (IL)- 12 alone or a combination of IL- 12 and granulocyte macrophage colony stimulating factor (GM-CSF). IL12 alone was noted to induce a Th1 polarized immune response, while the combination of IL12 and GM-CSF induced a significantly higher frequency of responding patients but with a Th2 profile. In the third study Id-specific T cell responses were monitored simultaneously in peripheral blood and bone marrow of 10 patients. Id-specific responses we found to occur at a similar frequency of patients in both compartments. Comparison of the responses during active immunization with those at the late follow-up showed that the responses decreased significantly by time and shifted from a Th1 to a Th2 profile. In the fourth study, 28 patients were immunized as indicated earlier over 110 weeks. Id-specific T cell responses were noted in 33% of patients in the IL- 12 group and 85% in the GM-CSF/IL 12 group (p - 0.003). Two third of the responsive patients subsequently lost their specific immunity while developing progressive disease. Median time to disease progression (TTP) was found to be significantly longer in immune responders compared to non-responders. Immune non-response was associated with an increase in the numbers of CD4+/CD25+ cells (Treg cells). Two patients in the IL-12 group had a clinical response (> 50% and > 25% reduction of their respective M-component concentrations). In the last study patients were monitored for an Id-specific T cell response, and the presence of circulating myeloma B cells (CMC) by real time ASO-PCR during a median time of 46 weeks of maintained ld vaccination. Reduction and/or stable levels of CMC were observed in 6/11 patients. Three patients showed progressive increase in the number of CMC and in 2 patients CMC could not be detected. Patients (n=6) who showed a reduction and/or a stable CMC level mounted an Id-specific T cell response, while those with increasing numbers of CMC (n=3) failed to mount tumor specific T cell immunity (p<0.02). Taken together, these results indicate that ld immunization in early stage MM patients can induce tumor-specific immune responses that may correlate with reduction of CMC as well as TTP, and clinical responses may also occur. Immune non-response may be associated with increased numbers of Treg cells and progressive disease. Adjuvant cytokines can be a versatile tool for manipulating and directing the anti-tumor immune response.
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| 10. |
- Abdalla, H., et al.
(author)
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Search for Dark Matter Annihilation Signals in the HESS Inner Galaxy Survey
- 2022
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In: Physical Review Letters. - : American Physical Society. - 0031-9007 .- 1079-7114. ; 129:11
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Journal article (peer-reviewed)abstract
- The central region of the Milky Way is one of the foremost locations to look for dark matter (DM) signatures. We report the first results on a search for DM particle annihilation signals using new observations from an unprecedented gamma-ray survey of the Galactic Center (GC) region, i.e., the Inner Galaxy Survey, at very high energies (& GSIM;100 GeV) performed with the H.E.S.S. array of five ground-based Cherenkov telescopes. No significant gamma-ray excess is found in the search region of the 2014-2020 dataset and a profile likelihood ratio analysis is carried out to set exclusion limits on the annihilation cross section (sigma v). Assuming Einasto and Navarro-Frenk-White (NFW) DM density profiles at the GC, these constraints are the strongest obtained so far in the TeV DM mass range. For the Einasto profile, the constraints reach (sigma v) values of 3.7 x 10-26 cm3 s-1 for 1.5 TeV DM mass in the W+W- annihilation channel, and 1.2 x 10-26 cm3 s-1 for 0.7 TeV DM mass in the tau+tau- annihilation channel. With the H.E.S.S. Inner Galaxy Survey, ground-based gamma-ray observations thus probe (sigma v) values expected from thermal-relic annihilating TeV DM particles.
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