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- Conde, Javier, et al.
(författare)
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Applying digital twins for the management of information in turnaround event operations in commercial airports
- 2022
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Ingår i: Advanced Engineering Informatics. - : Elsevier BV. - 1474-0346 .- 1873-5320. ; 54, s. 101723-
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Tidskriftsartikel (refereegranskat)abstract
- The aerospace sector is one of the many sectors in which large amounts of data are generated. Thanks to the evolution of technology, these data can be exploited in several ways to improve the operation and management of industrial processes. However, to achieve this goal, it is necessary to define architectures and data models that allow to manage and homogenise the heterogeneous data collected. In this paper, we present an Airport Digital Twin Reference Conceptualisation's and data model based on FIWARE Generic Enablers and the Next Generation Service Interfaces-Linked Data standard. Concretely, we particularise the Airport Digital Twin to improve the efficiency of flight turnaround events. The architecture proposed is validated in the Aberdeen International Airport with the aim of reducing delays in commercial flights. The implementation includes an application that shows the real state of the airport, combining two-dimensional and three-dimensional virtual reality representations of the stands, and a mobile application that helps ground operators to schedule departure and arrival flights.
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2. |
- Young, William J., et al.
(författare)
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
- 2022
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 13
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Tidskriftsartikel (refereegranskat)abstract
- The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascular disease. The QT interval is an electrocardiographic measure representing the sum of ventricular depolarization and repolarization, estimated by QRS duration and JT interval, respectively. QT interval abnormalities are associated with potentially fatal ventricular arrhythmia. Using genome-wide multi-ancestry analyses (>250,000 individuals) we identify 177, 156 and 121 independent loci for QT, JT and QRS, respectively, including a male-specific X-chromosome locus. Using gene-based rare-variant methods, we identify associations with Mendelian disease genes. Enrichments are observed in established pathways for QT and JT, and previously unreported genes indicated in insulin-receptor signalling and cardiac energy metabolism. In contrast for QRS, connective tissue components and processes for cell growth and extracellular matrix interactions are significantly enriched. We demonstrate polygenic risk score associations with atrial fibrillation, conduction disease and sudden cardiac death. Prioritization of druggable genes highlight potential therapeutic targets for arrhythmia. Together, these results substantially advance our understanding of the genetic architecture of ventricular depolarization and repolarization.
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