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Träfflista för sökning "(WFRF:(Collier David Andrew)) srt2:(2010-2014)"

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1.	Thorleifsson, Gudmar, et al. (author) Common variants near CAV1 and CAV2 are associated with primary open-angle glaucoma 2010 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 42:10, s. 906-909 Journal article (peer-reviewed)abstract We conducted a genome-wide association study for primary open-angle glaucoma (POAG) in 1,263 affected individuals (cases) and 34,877 controls from Iceland. We identified a common sequence variant at 7q31 (rs4236601[ A], odds ratio (OR) = 1.36, P = 5.0 x 10(-10)). We then replicated the association in sample sets of 2,175 POAG cases and 2,064 controls from Sweden, the UK and Australia (combined OR = 1.18, P = 0.0015) and in 299 POAG cases and 580 unaffected controls from Hong Kong and Shantou, China (combined OR = 5.42, P = 0.0021). The risk variant identified here is located close to CAV1 and CAV2, both of which are expressed in the trabecular meshwork and retinal ganglion cells that are involved in the pathogenesis of POAG.
2.	Keeling, Patrick J, et al. (author) The Marine Microbial Eukaryote Transcriptome Sequencing Project (MMETSP): Illuminating the Functional Diversity of Eukaryotic Life in the Oceans through Transcriptome Sequencing. 2014 In: PLoS Biology. - : Public Library of Science (PLoS). - 1545-7885. ; 12:6 Journal article (peer-reviewed)abstract Current sampling of genomic sequence data from eukaryotes is relatively poor, biased, and inadequate to address important questions about their biology, evolution, and ecology; this Community Page describes a resource of 700 transcriptomes from marine microbial eukaryotes to help understand their role in the world's oceans.
3.	Ternouth, Andrew, et al. (author) Association study of POMC variants with body composition measures and nutrient choice. 2011 In: European journal of pharmacology. - : Elsevier BV. - 1879-0712 .- 0014-2999. ; 660:1, s. 220-225 Journal article (peer-reviewed)abstract Genome linkage scans and candidate gene studies have implicated the pro-opiomelanocortin (POMC) locus in traits related to food intake, metabolic function, and body mass index. Here we investigate single nucleotide polymorphisms at the POMC locus in order to evaluate the influence of its genetic variance on body fat distribution and diet in a sample of middle-aged men from The Netherlands. 366 Dutch males from the Hamlet cohort were asked detailed questions about food choice, nutrient intake and exercise. Furthermore, their weight and body fat composition were measured. Each cohort member was genotyped for a set of single nucleotide polymorphisms (SNPs) at the POMC locus. Regression analysis, adjusted for several covariates, was used to test for the association between genetic variants and the phenotypes measured. POMC variation was associated with waist:hip ratio, visceral fat and abdominal fat (rs6713532, P=0.020, 0.019, and 0.021, respectively), and nutrient choice (rs1042571, P=0.034), but in light of limited power and multiple testing these results should be taken with caution. POMC is a strong candidate for involvement in appetite regulation as supported by animal, physiological, and genetic studies and variation at the POMC locus may affect an individual's energy intake which in turn leads to variation in body composition and body fat.

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Type of publication: journal article (3)

Type of content: peer-reviewed (3)

Author/Editor: Adan, Roger A H (1); Burki, Fabien (1); Edvardsen, Bente (1); Kudryavtsev, Alexand ... (1); Rengefors, Karin (1); Wadelius, Claes (1); show more...; John, Uwe (1); Thorleifsson, Gudmar (1); Thorsteinsdottir, Un ... (1); Stefansson, Kari (1); Martin, Nicholas G. (1); Lovejoy, Connie (1); MacGregor, Stuart (1); Helgason, Agnar (1); Sigurdsson, Asgeir (1); Kong, Augustine (1); Jansson, John-Olov, ... (1); Hammond, Christopher ... (1); Stefánsson, Hreinn (1); van der Schouw, Yvon ... (1); Trembath, Richard C. (1); Jakobsen, Kjetill S. (1); Lin, Senjie (1); Archibald, John M. (1); Xu, Yan (1); Leander, Brian S. (1); Keeling, Patrick J. (1); Bidle, Kay D. (1); Simpson, Alastair G. ... (1); Armbrust, E. Virgini ... (1); Mitchell, Paul (1); Chan, Juliana C N (1); Campbell, Lisa (1); St Clair, David (1); Pawlowski, Jan (1); Mock, Thomas (1); Slamovits, Claudio H ... (1); Worden, Alexandra Z. (1); Bharti, Arvind K. (1); Gates, Ruth D (1); Zingone, Adriana (1); Montresor, Marina (1); Masson, Gisli (1); Schroeder, Declan C. (1); Tang, Nelson (1); Jonasdottir, Adalbjo ... (1); Walters, G. Bragi (1); Magnusson, Kristinn ... (1); Collier, David A. (1); Collier, David (1); show less...

University: University of Gothenburg (1); Uppsala University (1); Lund University (1)

Language: English (3)

Research subject (UKÄ/SCB): Natural sciences (1); Medical and Health Sciences (1)

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