| 1. |
- Murari, A., et al.
(author)
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A control oriented strategy of disruption prediction to avoid the configuration collapse of tokamak reactors
- 2024
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In: Nature Communications. - 2041-1723 .- 2041-1723. ; 15:1
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Journal article (peer-reviewed)abstract
- The objective of thermonuclear fusion consists of producing electricity from the coalescence of light nuclei in high temperature plasmas. The most promising route to fusion envisages the confinement of such plasmas with magnetic fields, whose most studied configuration is the tokamak. Disruptions are catastrophic collapses affecting all tokamak devices and one of the main potential showstoppers on the route to a commercial reactor. In this work we report how, deploying innovative analysis methods on thousands of JET experiments covering the isotopic compositions from hydrogen to full tritium and including the major D-T campaign, the nature of the various forms of collapse is investigated in all phases of the discharges. An original approach to proximity detection has been developed, which allows determining both the probability of and the time interval remaining before an incoming disruption, with adaptive, from scratch, real time compatible techniques. The results indicate that physics based prediction and control tools can be developed, to deploy realistic strategies of disruption avoidance and prevention, meeting the requirements of the next generation of devices.
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| 2. |
- Alqasim, A., et al.
(author)
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TOI−757 b: an eccentric transiting mini−Neptune on a 17.5−d orbit
- 2024
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In: Monthly Notices of the Royal Astronomical Society. - 0035-8711 .- 1365-2966. ; 533:1, s. 1-26
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Journal article (peer-reviewed)abstract
- We report the spectroscopic confirmation and fundamental properties of TOI−757 b, a mini−Neptune on a 17.5−d orbit transiting a bright star (V = 9.7 mag) discovered by the TESS mission. We acquired high−precision radial velocity measurements with the HARPS, ESPRESSO, and PFS spectrographs to confirm the planet detection and determine its mass. We also acquired space−borne transit photometry with the CHEOPS space telescope to place stronger constraints on the planet radius, supported with ground−based LCOGT photometry. WASP and KELT photometry were used to help constrain the stellar rotation period. We also determined the fundamental parameters of the host star. We find that TOI−757 b has a radius of Rp = 2.5 ± 0.1R. and a mass of Mp = 10.5+−2212M, implying a bulk density of ρp = 3.6 ± 0.8 g cm−3. Our internal composition modelling was unable to constrain the composition of TOI−757 b, highlighting the importance of atmospheric observations for the system. We also find the planet to be highly eccentric with e = 0.39+−000708, making it one of the very few highly eccentric planets among precisely characterized mini−Neptunes. Based on comparisons to other similar eccentric systems, we find a likely scenario for TOI−757 b’s formation to be high eccentricity migration due to a distant outer companion. We additionally propose the possibility of a more intrinsic explanation for the high eccentricity due to star−star interactions during the earlier epoch of the Galactic disc formation, given the low metallicity and older age of TOI−757.
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| 3. |
- Billot, N., et al.
(author)
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In-situ observations of resident space objects with the CHEOPS space telescope
- 2024
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In: Journal of Space Safety Engineering. - 2468-8975 .- 2468-8967. ; In Press
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Journal article (peer-reviewed)abstract
- The CHaracterising ExOPlanet Satellite (CHEOPS) is a partnership between the European Space Agency and Switzerland with important contributions by 10 additional ESA member States. It is the first S-class mission in the ESA Science Programme. CHEOPS has been flying on a Sun-synchronous low Earth orbit since December 2019, collecting millions of short-exposure images in the visible domain to study exoplanet properties. A small yet increasing fraction of CHEOPS images show linear trails caused by resident space objects crossing the instrument field of view. CHEOPS’ orbit is indeed particularly favourable to serendipitously detect objects in its vicinity as the spacecraft rarely enters the Earth's shadow, sits at an altitude of 700 km, and observes with moderate phase angles relative to the Sun. This observing configuration is quite powerful, and it is complementary to optical observations from the ground. To characterize the population of satellites and orbital debris observed by CHEOPS, all and every science images acquired over the past 3 years have been scanned with a Hough transform algorithm to identify the characteristic linear features that these objects cause on the images. Thousands of trails have been detected. This statistically significant sample shows interesting trends and features such as an increased occurrence rate over the past years as well as the fingerprint of the Starlink constellation. The cross-matching of individual trails with catalogued objects is underway as we aim to measure their distance at the time of observation and deduce the apparent magnitude of the detected objects. As space agencies and private companies are developing new space-based surveillance and tracking activities to catalogue and characterize the distribution of small debris, the CHEOPS experience is timely and relevant. With the first CHEOPS mission extension currently running until the end of 2026, and a possible second extension until the end of 2029, the longer time coverage will make our dataset even more valuable to the community, especially for characterizing objects with recurrent crossings.
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| 4. |
- Egger, J. A., et al.
(author)
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Unveiling the internal structure and formation history of the three planets transiting HIP 29442 (TOI-469) with CHEOPS
- 2024
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 688
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Journal article (peer-reviewed)abstract
- Multiplanetary systems spanning the radius valley are ideal testing grounds for exploring the different proposed explanations for the observed bimodality in the radius distribution of close-in exoplanets. One such system is HIP 29442 (TOI-469), an evolved K0V star hosting two super-Earths and one sub-Neptune. We observed HIP 29442 with CHEOPS for a total of 9.6 days, which we modelled jointly with two sectors of TESS data to derive planetary radii of 3.410 ± 0.046, 1.551 ± 0.045, and 1.538 ± 0.049 R? for planets b, c, and d, which orbit HIP 29442 with periods of 13.6, 3.5, and 6.4 days, respectively. For planet d this value deviates by more than 3s from the median value reported in the discovery paper, leading us to conclude that caution is required when using TESS photometry to determine the radii of small planets with low per-transit signal-to-noise ratios and large gaps between observations. Given the high precision of these new radii, combining them with published RVs from ESPRESSO and HIRES provides us with ideal conditions to investigate the internal structure and formation pathways of the planets in the system. We introduced the publicly available code plaNETic, a fast and robust neural network-based Bayesian internal structure modelling framework. We then applied hydrodynamic models to explore the upper atmospheric properties of these inferred structures. Finally, we identified planetary system analogues in a synthetic population generated with the Bern model for planet formation and evolution. Based on this analysis, we find that the planets likely formed on opposing sides of the water iceline from a protoplanetary disk with an intermediate solid mass. We finally report that the observed parameters of the HIP 29442 system are compatible with a scenario where the second peak in the bimodal radius distribution corresponds to sub-Neptunes with a pure H/He envelope and with a scenario with water-rich sub-Neptunes.
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| 5. |
- Sulis, S., et al.
(author)
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HIP 41378 observed by CHEOPS: Where is planet d?
- 2024
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In: Astronomy and Astrophysics. - 0004-6361 .- 1432-0746. ; 686
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Journal article (peer-reviewed)abstract
- HIP 41378 d is a long-period planet that has only been observed to transit twice, three years apart, with K2. According to stability considerations and a partial detection of the Rossiter- McLaughlin effect, Pd = 278.36 d has been determined to be the most likely orbital period. We targeted HIP 41378 d with CHEOPS at the predicted transit timing based on Pd = 278.36 d, but the observations show no transit. We find that large (> 22.4 h) transit timing variations (TTVs) could explain this non-detection during the CHEOPS observation window. We also investigated the possibility of an incorrect orbital solution, which would have major implications for our knowledge of this system. If Pd ≠ 278.36 d, the periods that minimize the eccentricity would be 101.22 d and 371.14 d. The shortest orbital period will be tested by TESS, which will observe HIP 41378 in Sector 88 starting in January 2025. Our study shows the importance of a mission like CHEOPS, which today is the only mission able to make long observations (i.e., from space) to track the ephemeris of long-period planets possibly affected by large TTVs.
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| 8. |
- Ercan, Ayse Bahar, et al.
(author)
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Clinical and biological landscape of constitutional mismatch-repair deficiency syndrome: an International Replication Repair Deficiency Consortium cohort study.
- 2024
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In: The Lancet Oncology. - : ELSEVIER SCIENCE INC. - 1470-2045 .- 1474-5488. ; 25:5, s. 668-682
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Journal article (peer-reviewed)abstract
- Constitutional mismatch repair deficiency (CMMRD) syndrome is a rare and aggressive cancer predisposition syndrome. Because a scarcity of data on this condition contributes to management challenges and poor outcomes, we aimed to describe the clinical spectrum, cancer biology, and impact of genetics on patient survival in CMMRD.In this cohort study, we collected cross-sectional and longitudinal data on all patients with CMMRD, with no age limits, registered with the International Replication Repair Deficiency Consortium (IRRDC) across more than 50 countries. Clinical data were extracted from the IRRDC database, medical records, and physician-completed case record forms. The primary objective was to describe the clinical features, cancer spectrum, and biology of the condition. Secondary objectives included estimations of cancer incidence and of the impact of the specific mismatch-repair gene and genotype on cancer onset and survival, including after cancer surveillance and immunotherapy interventions.We analysed data from 201 patients (103 males, 98 females) enrolled between June 5, 2007 and Sept 9, 2022. Median age at diagnosis of CMMRD or a related cancer was 8·9 years (IQR 5·9-12·6), and median follow-up from diagnosis was 7·2 years (3·6-14·8). Endogamy among minorities and closed communities contributed to high homozygosity within countries with low consanguinity. Frequent dermatological manifestations (117 [93%] of 126 patients with complete data) led to a clinical overlap with neurofibromatosis type 1 (35 [28%] of 126). 339 cancers were reported in 194 (97%) of 201 patients. The cumulative cancer incidence by age 18 years was 90% (95% CI 80-99). Median time between cancer diagnoses for patients with more than one cancer was 1·9 years (IQR 0·8-3·9). Neoplasms developed in 15 organs and included early-onset adult cancers. CNS tumours were the most frequent (173 [51%] cancers), followed by gastrointestinal (75 [22%]), haematological (61 [18%]), and other cancer types (30 [9%]). Patients with CNS tumours had the poorest overall survival rates (39% [95% CI 30-52] at 10 years from diagnosis; log-rank p<0·0001 across four cancer types), followed by those with haematological cancers (67% [55-82]), gastrointestinal cancers (89% [81-97]), and other solid tumours (96% [88-100]). All cancers showed high mutation and microsatellite indel burdens, and pathognomonic mutational signatures. MLH1 or MSH2 variants caused earlier cancer onset than PMS2 or MSH6 variants, and inferior survival (overall survival at age 15 years 63% [95% CI 55-73] for PMS2, 49% [35-68] for MSH6, 19% [6-66] for MLH1, and 0% for MSH2; p<0·0001). Frameshift or truncating variants within the same gene caused earlier cancers and inferior outcomes compared with missense variants (p<0·0001). The greater deleterious effects of MLH1 and MSH2 variants as compared with PMS2 and MSH6 variants persisted despite overall improvements in survival after surveillance or immune checkpoint inhibitor interventions.The very high cancer burden and unique genomic landscape of CMMRD highlight the benefit of comprehensive assays in timely diagnosis and precision approaches toward surveillance and immunotherapy. These data will guide the clinical management of children and patients who survive into adulthood with CMMRD.The Canadian Institutes for Health Research, Stand Up to Cancer, Children's Oncology Group National Cancer Institute Community Oncology Research Program, Canadian Cancer Society, Brain Canada, The V Foundation for Cancer Research, BioCanRx, Harry and Agnieszka Hall, Meagan's Walk, BRAINchild Canada, The LivWise Foundation, St Baldrick Foundation, Hold'em for Life, and Garron Family Cancer Center.
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