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- Rodriguez, L. , V, et al.
(author)
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Doubly-magic character of Sn-132 studied via electromagnetic moments of( 13)(3)Sn
- 2020
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In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 102:5
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Journal article (peer-reviewed)abstract
- We report the first measurement of the magnetic dipole and electric quadrupole moment of the exotic nucleus Sn-133 by high-resolution laser spectroscopy at ISOLDE/CERN. These, in combination with state-of-the-art shell-model calculations, demonstrate the single-particle character of the ground state of this short-lived isotope and, hence, the doubly-magic character of its immediate neighbor Sn-132. The trend of the electromagnetic moments along the N = 83 isotonic chain, now enriched with the values of tin, are discussed on the basis of realistic shell-model calculations.
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| 2. |
- Mukai, M., et al.
(author)
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In-gas-cell laser resonance ionization spectroscopy of Ir-196,Ir-197,Ir-198
- 2020
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In: Physical Review C. - : American Physical Society. - 2469-9985 .- 2469-9993. ; 102:5
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Journal article (peer-reviewed)abstract
- Hyperfine structure (HFS) measurements of neutron-rich iridium isotopes Ir-196,Ir-197,Ir-198 (Z = 77, N = 119-121) were performed via in-gas-cell laser resonance ionization spectroscopy at the KEK Isotope Separation System. Magnetic dipole moments mu and isotope shifts were determined from the HFS spectra. The variation of mean-square charge radii and quadrupole deformation parameters of these isotopes were evaluated from the isotope shifts. The mu value of (197)h, agreed with a theoretical value based on the strong coupling model, and the Ir nucleus was interpreted as prolately deformed by the theoretical calculations. The mu values of Ir-196,Ir-198 were also compared with semiempirical values calculated based on the strong coupling model. From the comparison, we can suggest the possible spin values of I-pi = 1,2(-) for Ir-196 and I-pi = 1(-) for Ir-198.
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| 4. |
- Papakokkinou, Eleni, et al.
(author)
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Prevalence of Nelson's syndrome after bilateral adrenalectomy in patients with cushing's disease: a systematic review and meta-analysis
- 2021
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In: Pituitary. - : Springer Science and Business Media LLC. - 1386-341X .- 1573-7403.
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Journal article (peer-reviewed)abstract
- Purpose Bilateral adrenalectomy (BA) still plays an important role in the management of Cushing's disease (CD). Nelson's syndrome (NS) is a severe complication of BA, but conflicting data on its prevalence and predicting factors have been reported. The aim of this study was to determine the prevalence of NS, and identify factors associated with its development. Data sources Systematic literature search in four databases. Study Selection Observational studies reporting the prevalence of NS after BA in adult patients with CD. Data extraction Data extraction and risk of bias assessment were performed by three independent investigators. Data synthesis Thirty-six studies, with a total of 1316 CD patients treated with BA, were included for the primary outcome. Pooled prevalence of NS was 26% (95% CI 22-31%), with moderate to high heterogeneity (I-2 67%, P < 0.01). The time from BA to NS varied from 2 months to 39 years. The prevalence of NS in the most recently published studies, where magnet resonance imaging was used, was 38% (95% CI 27-50%). The prevalence of treatment for NS was 21% (95% CI 18-26%). Relative risk for NS was not significantly affected by prior pituitary radiotherapy [0.9 (95% CI 0.5-1.6)] or pituitary surgery [0.6 (95% CI 0.4-1.0)]. Conclusions Every fourth patient with CD treated with BA develops NS, and every fifth patient requires pituitary-specific treatment. The risk of NS may persist for up to four decades after BA. Life-long follow-up is essential for early detection and adequate treatment of NS.
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- Cedres, N, et al.
(author)
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Brain Atrophy Subtypes and the ATN Classification Scheme in Alzheimer's Disease
- 2021
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In: Neuro-degenerative diseases. - : S. Karger AG. - 1660-2862 .- 1660-2854. ; 20:4, s. 153-164
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Journal article (peer-reviewed)abstract
- <b><i>Introduction:</i></b> We investigated the association between atrophy subtypes of Alzheimer’s disease (AD), the ATN classification scheme, and key demographic and clinical factors in 2 cohorts with different source characteristics (a highly selective research-oriented cohort, the Alzheimer’s Disease Neuroimaging Initiative [ADNI]; and a naturalistic heterogeneous clinically oriented cohort, Karolinska Imaging Dementia Study [KIDS]). <b><i>Methods:</i></b> A total of 382 AD patients were included. Factorial analysis of mixed data was used to investigate associations between AD subtypes based on brain atrophy patterns, ATN profiles based on cerebrospinal fluid biomarkers, and age, sex, Mini Mental State Examination (MMSE), cerebrovascular disease (burden of white matter signal abnormalities, WMSAs), and <i>APOE</i> genotype. <b><i>Results:</i></b> Older patients with high WMSA burden, belonging to the typical AD subtype and showing A+T+N+ or A+T+N− profiles clustered together and were mainly from ADNI. Younger patients with low WMSA burden, limbic-predominant or minimal atrophy AD subtypes, and A+T−N− or A+T−N+ profiles clustered together and were mainly from KIDS. <i>APOE</i> ε4 carriers more frequently showed the A+T−N− and A+T+N− profiles. <b><i>Conclusions:</i></b> Our findings align with the recent framework for biological subtypes of AD: the combination of risk factors, protective factors, and brain pathologies determines belonging of AD patients to distinct subtypes.
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