| 1. |
- Law, Philip J., et al.
(author)
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Genome-wide association analysis of chronic lymphocytic leukaemia, Hodgkin lymphoma and multiple myeloma identifies pleiotropic risk loci
- 2017
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In: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
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Journal article (peer-reviewed)abstract
- B-cell malignancies (BCM) originate from the same cell of origin, but at different maturation stages and have distinct clinical phenotypes. Although genetic risk variants for individual BCMs have been identified, an agnostic, genome-wide search for shared genetic susceptibility has not been performed. We explored genome-wide association studies of chronic lymphocytic leukaemia (CLL, N = 1,842), Hodgkin lymphoma (HL, N = 1,465) and multiple myeloma (MM, N = 3,790). We identified a novel pleiotropic risk locus at 3q22.2 (NCK1, rs11715604, P = 1.60 × 10-9) with opposing effects between CLL (P = 1.97 × 10-8) and HL (P = 3.31 × 10-3). Eight established non-HLA risk loci showed pleiotropic associations. Within the HLA region, Ser37 + Phe37 in HLA-DRB1 (P = 1.84 × 10-12) was associated with increased CLL and HL risk (P = 4.68 × 10-12), and reduced MM risk (P = 1.12 × 10-2), and Gly70 in HLA-DQB1 (P = 3.15 × 10-10) showed opposing effects between CLL (P = 3.52 × 10-3) and HL (P = 3.41 × 10-9). By integrating eQTL, Hi-C and ChIP-seq data, we show that the pleiotropic risk loci are enriched for B-cell regulatory elements, as well as an over-representation of binding of key B-cell transcription factors. These data identify shared biological pathways influencing the development of CLL, HL and MM. The identification of these risk loci furthers our understanding of the aetiological basis of BCMs.
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| 2. |
- Zejlon, C, et al.
(author)
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Structural magnetic resonance imaging findings and histopathological correlations in motor neuron diseases-A systematic review and meta-analysis
- 2022
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In: Frontiers in neurology. - : Frontiers Media SA. - 1664-2295. ; 13, s. 947347-
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Research review (other academic/artistic)abstract
- The lack of systematic evidence on neuroimaging findings in motor neuron diseases (MND) hampers the diagnostic utility of magnetic resonance imaging (MRI). Thus, we aimed at performing a systematic review and meta-analysis of MRI features in MND including their histopathological correlation.MethodsIn a comprehensive literature search, out of 5941 unique publications, 223 records assessing brain and spinal cord MRI findings in MND were eligible for a qualitative synthesis. 21 records were included in a random effect model meta-analysis.ResultsOur meta-analysis shows that both T2-hyperintensities along the corticospinal tracts (CST) and motor cortex T2*-hypointensitites, also called “motor band sign”, are more prevalent in ALS patients compared to controls [OR 2.21 (95%-CI: 1.40–3.49) and 10.85 (95%-CI: 3.74–31.44), respectively]. These two imaging findings correlate to focal axonal degeneration/myelin pallor or glial iron deposition on histopathology, respectively. Additionally, certain clinical MND phenotypes such as amyotrophic lateral sclerosis (ALS) seem to present with distinct CNS atrophy patterns.ConclusionsAlthough CST T2-hyperintensities and the “motor band sign” are non-specific imaging features, they can be leveraged for diagnostic workup of suspected MND cases, together with certain brain atrophy patterns. Collectively, this study provides high-grade evidence for the usefulness of MRI in the diagnostic workup of suspected MND cases.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42020182682.
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| 3. |
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| 4. |
- Esberg, Anders, et al.
(author)
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Site- and Time-Dependent Compositional Shifts in Oral Microbiota Communities
- 2022
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In: Frontiers in oral health. - : Frontiers Media S.A.. - 2673-4842. ; 3
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Journal article (peer-reviewed)abstract
- Objectives: The oral microbiota plays a significant role in oral health. The present study aims to characterize variations in the oral microbiota relative to the collection site, the dynamics of biofilm accumulation, and inherent inter-individual differences.Methods: Whole stimulated saliva and tooth biofilm samples from the 16 defined tooth regions were collected after 1, 2, or 3 days without oral hygiene (accumulation time) in six healthy adults with no signs of active caries or periodontal disease. The routines and conditions before and between sample collections were carefully standardized. Genomic DNA was extracted, and the V3-V4 regions of the 16S rRNA gene were amplified by PCR and sequenced on an Illumina MiSeq platform. Sequences were quality controlled, amplicon sequence variants (ASVs) were clustered, and taxonomic allocation was performed against the expanded Human Oral Microbiome Database (eHOMD). Microbial community profiles were analyzed by multivariate modeling and a linear discriminant analysis (LDA) effect size (LEfSe) method.Results: The overall species profile in saliva and tooth biofilm differed between participants, as well as sample type, with a significantly higher diversity in tooth biofilm samples than saliva. On average, 45% of the detected species were shared between the two sample types. The microbiota profile changed from the most anterior to the most posterior tooth regions regardless of whether sampling was done after 1, 2, or 3 days without oral hygiene. Increasing accumulation time led to higher numbers of detected species in both the saliva and region-specific tooth biofilm niches.Conclusion: The present study confirms that the differences between individuals dominate over sample type and the time abstaining from oral hygiene for oral microbiota shaping. Therefore, a standardized accumulation time may be less important for some research questions aiming at separating individuals. Furthermore, the amount of DNA is sufficient if at least two teeth are sampled for microbiota characterization, which allows a site-specific characterization of, for example, caries or periodontitis.
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| 5. |
- Jiang, Yuchen, et al.
(author)
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CLT-concrete composite floors with notched shear connectors
- 2019
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In: Construction and Building Materials. - : ELSEVIER SCI LTD. - 0950-0618 .- 1879-0526. ; 195, s. 127-139
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Journal article (peer-reviewed)abstract
- The aim of the paper is to gain data on the mechanical behaviour of CLT-concrete composite floors and subsequently to check if commonly adopted analysis methods are suitable for this particular type of structure. The studies are conducted through laboratory tests, analytical models and numerical modelling. In the shear tests, the notched connections presented considerable stiffness and shear capacity, and failed eventually with shear fracture in the concrete. The bending test results showed that the CLT-concrete composite floors with notched connections had a very high composite action. At the moment of failure, all notched connections along the span remained nearly undamaged, and only one fine concrete crack appeared at the notch near the support. The paper also presents a theoretical calculation method based on the well-known gamma-method, which is suitable for CLT-concrete composite floors. In particular, for the composite floors with 5-layer-CLT panel, a model using a combined distributed stiffness is introduced to take account of the stiffness of both the mechanical fasteners and the CLT's cross layer, which extends the validity range of the gamma-method to composite systems made of CLT panels with more than three layers. Three-dimensional FE-models for CLT-concrete notched connections and for composite floors are developed using the commercial finite element programme ABAQUS. With the FE-models calibrated with experimental results, parametric studies are conducted to investigate the influence of the notch depth on the mechanical performance of both notched connections and CLT-concrete composite floors. It is concluded that the stiffness of notched connections increases linearly with the depth of the notch, while it is not this case for the shear capacity. The variation of notch depth within the investigated range, i.e. 15 mm to 35 mm, is found to have no significant influence on the load-deflection response of composite floors.
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| 6. |
- Maurice, Christian
(author)
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Växter och förorenad mark
- 2001
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In: Nordrutan. - 1401-3533. ; 6:1, s. 32-39
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Journal article (other academic/artistic)
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| 7. |
- Wu, Di, et al.
(author)
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VLSI Implementation of A Multi-Standard MIMO Symbol Detector for 3GPP LTE and WiMAX
- 2010
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In: Wireless Telecommunications Symposium (WTS), 2010. - : IEEE. - 9781424465583 ; , s. 1-4
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Conference paper (peer-reviewed)abstract
- In this paper, a low-complexity symbol detector is presentedtargeting the emerging 3GPP LTE andWiMAX standards. The detector isthe VLSI implementation of a novel MIMO detection algorithm recentlyproposed. Compared to the design in the reference, the detector performsbetter while consumes less silicon area. Including a microcode controlledchannel preprocessing unit and a pipelined detection unit, it is flexibleenough to cover different standards and transmission schemes whilemaintaining the power and area efficiency. Implemented using 65 nmCMOS process, the detector can support real-time detection of 20 MHzbandwidth 3GPP LTE or 10 MHz WiMAX downlink physical channel.
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| 8. |
- Ahdida, C., et al.
(author)
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Fast simulation of muons produced at the SHiP experiment using Generative Adversarial Networks
- 2019
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In: Journal of Instrumentation. - : IOP PUBLISHING LTD. - 1748-0221. ; 14
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Journal article (peer-reviewed)abstract
- This paper presents a fast approach to simulating muons produced in interactions of the SPS proton beams with the target of the SHiP experiment. The SHIP experiment will be able to search for new long-lived particles produced in a 400 GeV/c SPS proton beam dump and which travel distances between fifty metres and tens of kilometers. The SHiP detector needs to operate under ultra-low background conditions and requires large simulated samples of muon induced background processes. Through the use of Generative Adversarial Networks it is possible to emulate the simulation of the interaction of 400 GeV/c proton beams with the SHiP target, an otherwise computationally intensive process. For the simulation requirements of the SHiP experiment, generative networks are capable of approximating the full simulation of the dense fixed target, offering a speed increase by a factor of O(10(6)). To evaluate the performance of such an approach, comparisons of the distributions of reconstructed muon momenta in SHiP's spectrometer between samples using the full simulation and samples produced through generative models are presented. The methods discussed in this paper can be generalised and applied to modelling any non-discrete multi-dimensional distribution.
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