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| 2. |
- Guerin, S, et al.
(author)
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Radiation dose as a risk factor for malignant melanoma following childhood cancer
- 2003
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In: European Journal of Cancer. - 1879-0852. ; 39:16, s. 2379-2386
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Journal article (peer-reviewed)abstract
- The aim of this study was to determine therapy-related risk factors for the development of melanoma after childhood cancer. Among 4401 3-year survivors of a childhood cancer in eight French and British centres and 25 120 patients younger than 20 years old at first malignant neoplasm (FMN) extracted from the Nordic Cancer Registries, 16 patients developed a melanoma as a second malignant neoplasm (SMN). A cohort study of the French and British cohorts was performed. In a nested case-control study, the 16 patients who developed a melanoma as a SMN (cases) were matched with 3-5 controls in their respective cohort according to gender, age at the first cancer, the calendar year of occurrence of the first cancer and follow-up. Radiotherapy appeared to increase the risk of melanoma for local doses > 15 Gy, Odds Ratio (OR)= 13 (95% Confidence Interval (CI): 0.94-174). Regarding chemotherapy, we observed an increased OR for both alkylating agents and spindle inhibitors, OR 2.7 (95% CI: 0.5-14). Children treated for a gonadal tumour as a FMN were found to be at a higher risk of melanoma, OR 8.7 (95% CI: 0.9-86). The adjusted OR for the local radiation dose was 1.07 (95% CI: 1.00-1.15). In conclusion, radiotherapy may contribute to an increased risk of melanoma as a SMN, but only at very high doses of low linear energy transfer radiation. Common genetic origins between gonadal tumours and malignant melanomas are likely. (C) 2003 Elsevier Ltd. All rights reserved.
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| 3. |
- Lerceteau-Köhler, Estelle, et al.
(author)
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QTL analysis for fruit quality traits and resistance to Colletotrichum acutatum and Phytophthora cactorum in octoploid strawberry (Fragaria x ananassa)
- 2004
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In: PROCEEDINGS OF THE EURO BERRY SYMPOSIUM - COST 836 FINAL WORSKHOP. - : INT SOC HORTICULTURAL SCIENCE. ; , s. 93-97
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Conference paper (peer-reviewed)abstract
- Mapping of quantitative trait loci (QTL) controlling components of strawberry (Fragaria x ananassa Duch., 2n=8x=56) fruit quality and resistance to Colletotrichum acutatum and Phytophthora cactorum can be used to provide a better understanding of the genetic control of the traits, and to develop marker assisted selection for breeders. A segregating population of 213 individuals of a cross between ‘Capitola’ and ‘CF1116’, two genotypes with many contrasting fruit quality traits, was used for genetic mapping. ‘Capitola’ was resistant to the C. acutatum pathogenicity group 1 (pg1) and to P. cactorum while ‘CF1116’ was susceptible to C. acutatum and moderately susceptible to P. cactorum. Fruit quality was evaluated on a total of 34 traits, including developmental and fruit aspect related traits, texture related traits, fruit acidity, sugars, ascorbate and amino acid concentrations. Most of the traits except the amino acid concentrations were evaluated during two successive years. Disease responses to C. acutatum (pg2) and P. cactorum were evaluated using a scale from 0 (no observed symptom) to 5 (dead plant) in two successive independent experiments. Data were analysed for putative QTLs using MapQTL. For the fruit quality traits, a total of 22 significant QTLs were detected by simple interval mapping (LOD>3.0) in the first year of analyses and 17 were detected in the second year. Only two QTLs could be detected in both years. The percentages of phenotypic variance explained by each QTL ranged from 6.5% to 16.0%. For resistances, a total of nine QTLs was detected (LOD>2.0), 4 for resistance to C acutatum and 5 for resistance to P. cactorum with the percentage of variation explained by a QTL ranging from 6.5 to 12.2%. No QTL for the P. cactorum resistance overlapped the QTLs for the C acutatum resistance.
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| 4. |
- Lerceteau-Köhler, Estelle, et al.
(author)
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QTL analysis for fruit quality traits in octoploid strawberry (Fragaria x ananassa)
- 2004
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In: PROCEEDINGS OF THE XITH EUCARPIA SYMPOSIUM ON FRUIT BREEDING AND GENETICS, VOLS 1 AND 2. - : INT SOC HORTICULTURAL SCIENCE. ; , s. 331-335
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Conference paper (peer-reviewed)abstract
- Mapping of quantitative trait loci (QTL) controlling components of strawberry (Fragaria x ananassa Duch., 2n=8x=56) fruit quality can be used to provide a better understanding of their genetic control, and to develop marker assisted selection for breeders. For this purpose, a segregating population of 213 individuals of a cross between ‘Capitola’ and CF1116, two genotypes with many contrasting fruit quality traits, was used for genetic mapping. A total of 34 traits involved in fruit quality were evaluated, including developmental and fruit aspect related traits, texture related traits, fruit acidity, sugar and ascorbate concentrations. Amino acid concentrations were quantified using one-dimensional proton NMR spectroscopy. Most of the traits except the amino acid concentrations were evaluated during two successive years. A total of 22 significant QTLs were detected by simple interval mapping (LOD > 3.0) in year 1, four on the female map and 18 on the male map, whereas 17 were detected in year 2, ten on the female map and seven on the male map. Only two QTLs could be detected in both years. When removing the year effect, 22 QTLs were observed, eight on the female and 14 on the male map. The percentages of phenotypic variance explained by each QTL ranged from 6.5% to 16.0%.
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| 5. |
- Lerceteau-Köhler, Estelle, et al.
(author)
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The use of molecular markers for durable resistance breeding in the cultivated strawberry (Fragaria x ananassa)
- 2002
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In: PROCEEDINGS OF THE FOURTH INTERNATIONAL STRAWBERRY SYMPOSIUM, VOLS 1 AND 2. - : INTERNATIONAL SOCIETY HORTICULTURAL SCIENCE. ; , s. 615-618
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Conference paper (peer-reviewed)abstract
- In France, particularly in the southwestern area, most damage to the cultivated strawberry is anthracnose, caused by Colletotrichum acutatum. Anthracnose is a polycyclic disease for which no satisfactory disease control method has been developed. Therefore, the objective of our project is to construct durable resistance by combining the different genetic components of resistance to lower both the level of damage and the use of chemicals. Genetic components will be selected by using molecular markers linked to these loci. For monogenic resistance to the pathogenicity group 2 of C. acutatum, bulk segregant analysis (BSA) combined with the AFLP markers has been developed. Four markers were found linked to the dominant gene with a recombination percentage ranging from 0 to 13.9%. For complex resistance to the pathogenicity group 1 of C. acutatum, a linkage map has been constructed in order to detect putative QTLs associated with this complex resistance. The female map was comprised of 31 SDRF (Single Dose Restriction Fragment) markers assigned to 11 linkage groups giving a total size of 392.9 cM. On the male map, 52 SDRF markers mapped on 17 linkage groups giving a total size of 406.9 cM. The work is being continued with the addition of more markers on the maps.
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