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Träfflista för sökning "(WFRF:(Hamsten Anders)) srt2:(2005-2009) srt2:(2006)"

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1.	Gustafsson, Ida, et al. (author) [Metabolic control by means of insulin in patients with type 2 diabetes and acute myocardial infarction (DIGAMI 2) : effects on mortality and morbidity--secondary publication] 2006 In: Ugeskr Laeger. - 1603-6824. ; 168:6, s. 581-584 Journal article (peer-reviewed)
2.	Zhu, Chaoyong, et al. (author) Allele-specific MMP-3 transcription under in vivo conditions 2006 In: Biochemical and Biophysical Research Communications - BBRC. - : Elsevier BV. - 0006-291X .- 1090-2104. ; 348:3, s. 1150-1156 Journal article (peer-reviewed)abstract A common matrix metalloproteinases-3 (MMP-3) -1612 5A/6A promoter polymorphism is associated with risk for cardiovascular disease, rheumatoid arthritis, and other diseases. Here we used the haplotype chromatin immunoprecipitation method to study allele-specific MMP-3 expression under in vivo conditions in heterozygous THP-1 cells. Pyrosequencing was used to analyse the ratio of 5A-allele to 6A-allele after chromatin immunoprecipitation using an antibody against phosphorylated active RNA polymerase II. There was no allele-specific difference in transcriptional activity during basal conditions, i.e., in unstimulated monocytic THP-1 cells. However, after stimulation of MMP-3 expression by monocyte differentiation or incubation with IL-1 beta, the haplotype containing the 5A-allete was associated with higher transcriptional activity compared with the 6A-containing haplotype. Electromobility shift assay demonstrated increased binding of nuclear proteins to the 5A-allele after monocyte differentiation. In conclusion, the common MMP-3 5A/6A promoter polymorphism appears to be functional only during specific environmental conditions involving inflammation.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Hamsten, Anders (2); Ryden, Lars (1); Herlitz, Johan (1); Waldenström, Anders (1); Efendic, Suad (1); Odeberg, Jacob (1); show more...; Wedel, Hans (1); Laakso, Markku (1); Eriksson, Per (1); Gustafsson, Ida (1); Dickstein, Kenneth (1); Birkeland, Kåre (1); Malmberg, Klas (1); Bootsma, Aart (1); Fisher, Miles (1); Hildebrandt, Per Ros ... (1); MacLeod, Kenneth (1); Torp-Pedersen, Chris ... (1); Zhu, Chaoyong (1); show less...

University: Umeå University (1); Royal Institute of Technology (1); Karolinska Institutet (1)

Language: English (2)

Year: 2006 (2)Undo refine

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