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Cases on professional distance education degree programs and practices : successes, challenges and issues
- 2013
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Editorial collection (peer-reviewed)abstract
- Although internet technologies have transformed the concept of professional development by providing the opportunity for virtual learning environments in a non-traditional setting, the implementation of professional distance education programs still poses a challenge.Cases on Professional Distance Education Degree Programs and Practices: Successes, Challenges, and Issues examines the best practices for executing technology applications and the utilization of distance education techniques. This publication will serve as a reference for academics and instructors coordinating distance education programs, initiating distance education courses, and implementing such programs for those earning professional degrees.
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| 2. |
- Ley, David, et al.
(author)
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Longitudinal infusion of a complex of insulin-like growth factor-I and IGF-binding protein-3 in five preterm infants : pharmacokinetics and short-term safety.
- 2013
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In: Pediatric Research. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 73:1, s. 68-74
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Journal article (peer-reviewed)abstract
- Background:In preterm infants, low levels of insulin-like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3) are associated with impaired brain growth and retinopathy of prematurity (ROP). Treatment with IGF-I/IGFBP-3 may be beneficial for brain development and may decrease the prevalence of ROP.Methods:In a phase II pharmacokinetics and safety study, five infants (three girls) with a median (range) gestational age (GA) of 26 wk + 6 d (26 wk + 0 d to 27 wk + 2 d) and birth weight of 990 (900-1,212) g received continuous intravenous infusion of recombinant human (rh)IGF-I/rhIGFBP-3. Treatment was initiated during the first postnatal day and continued for a median (range) duration of 168 (47-168) h in dosages between 21 and 111 µg/kg/24 h.Results:Treatment with rhIGF-I/rhIGFBP-3 was associated with higher serum IGF-I and IGFBP-3 concentrations (P < 0.001) than model-predicted endogenous levels. Of 74 IGF-I samples measured during study drug infusion, 37 (50%) were within the target range, 4 (5%) were above, and 33 (45%) were below. The predicted dose of rhIGF-I/rhIGFBP-3 required to establish circulating levels of IGF-I within the intrauterine range in a 1,000 g infant was 75-100 µg/kg/24 h. No hypoglycemia or other adverse effects were recorded.Conclusion:In this study, continuous intravenous infusion of rhIGF-I/rhIGFBP-3 was effective in increasing serum concentrations of IGF-I and IGFBP-3, and was found to be safe.
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| 3. |
- Ley, David, et al.
(author)
-
Longitudinal infusion of insulin-like growth factor-I and IGF-binding protein-3 complex to five preterm infants: pharmacokinetics and short term safety.
- 2013
-
In: Pediatric Research. - : Springer Science and Business Media LLC. - 0031-3998 .- 1530-0447. ; 63:1, s. 68-74
-
Journal article (peer-reviewed)abstract
- Background:In preterm infants, low levels of insulin like growth factor-I (IGF-I) and IGF binding protein 3 (IGFBP-3) are associated with impaired brain growth and retinopathy of prematurity (ROP).Treatment with IGF-I/IGFBP-3 may be beneficial for brain development and decrease prevalence of ROP.Methods:In a phase II pharmacokinetic and safety study, five infants (3 girls) with a median (range) gestational age (GA) of 26+6 (26+0 - 27+2) weeks and birth weight (BW) of 990 (900-1212) g received continuous intravenous infusion of rhIGF-I/rhIGFBP-3. Treatment was initiated during the first postnatal day and continued for median (range) 168h (47-168) in doses between 21 - 111 µg/kg/24h.Results:Treatment with rhIGF-I/rhIGFBP-3 was associated with higher serum IGF-I and IGFBP-3 concentrations (p<0.001) than model-predicted endogenous levels. Out of 74 IGF-I samples measured during study drug infusion, 37 (50%) were within target range, 4 (5%) above and 33 (45%) were below. Predicted dose of rhIGF-I/rhIGFBP-3 to establish circulating levels of IGF-I within the intrauterine range in a 1000g infant was 75-100 µg/kg/24h. No hypoglycemia or other adverse effects were recorded.Conclusion:Continuous intravenous infusion of rhIGF-I/rhIGFBP-3 was effective in increasing serum concentrations of IGF-I and IGFBP-3. Administration during study was safe.Pediatric Research (2012); doi:10.1038/pr.2012.146.
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| 4. |
- Pienaar, J., et al.
(author)
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The cognitive/affective distinction of job insecurity : validation and differential relations
- 2013
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In: Southern African Business Review. - 1998-8125. ; 17:2, s. 1-22
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Journal article (peer-reviewed)abstract
- Job insecurity as a work-related stressor is well established through three decades of research. It has been related to outcomes such as decreased job satisfaction, organisational commitment and performance as well as increased ill-health and organisational turnover. However, some important conceptual and theoretical issues are still under discussion, with implications for the measurement of the construct. We administered a short version of the measure of job insecurity originally devised by De Witte (2000), which distinguishes between cognitive and affective job insecurity. Data on job satisfaction, commitment, psychological ill-health and emotional exhaustion were also gathered from employees in a variety of South African organisations (N=1925) by means of anonymous surveys. Exploratory and confirmatory factor analyses revealed that the cognitive and affective dimensions of job insecurity could be distinguished in this sample of South African employees, and the two dimensions evidenced adequate reliability. Equivalence analyses showed that the measurement properties of the scale were invariant across various demographic groups. The relationships with outcome variables were investigated by means of correlations and regression analyses. Cognitive job insecurity was predictive of all outcome variables, whereas affective job insecurity primarily played a role for emotional exhaustion. Norm data concerning levels of cognitive and affective job insecurity are presented to guide future South African studies.
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