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Träfflista för sökning "(WFRF:(Holland C)) srt2:(2000-2004)"

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1.	Austin, A.T., et al. (author) Human disruption of element interactions: drivers, consequences and trends for the 21st century 2003 In: Interactions of the Major Biogeochemical Cycles: Global Change and Human Impacts. - 1559630655 - 1559630663 ; SCOPE 61 Book chapter (other academic/artistic)
2.	Fieschi, C, et al. (author) High levels of interferon gamma in the plasma of children with complete interferon gamma receptor deficiency 2001 In: Pediatrics. - : American Academy of Pediatrics (AAP). - 1098-4275 .- 0031-4005. ; 107:4, s. art. no.-e48 Journal article (peer-reviewed)abstract We have found that children with complete interferon gamma (IFNγ) receptor deficiency, unlike patients with other genetic defects predisposing them to mycobacterial diseases, have very high levels of IFNγ in their plasma. This unexpected observation provides a simple and accurate diagnostic method for complete IFNγ receptor deficiency in children with clinical disease caused by bacille Calmette-Guérin vaccines or environmental nontuberculous mycobacteria.
3.	Uhrbom, Lene, et al. (author) Ink4a-Arf loss cooperates with KRas activation in astrocytes and neuralprogenitors to generate glioblastomas of various morphologies depending onactivated Akt. 2002 In: Cancer Res. ; 62, s. 5551- Journal article (peer-reviewed)
4.	Begemann, Martin, et al. (author) Dissecting gliomagemesis using glial-specifictransgenic mouse models 2003 In: Genomic and Molecular Neuro-Oncology. - : Jones & Bartlett Publishers, Inc. Book chapter (other academic/artistic)
5.	Shaw, CA, et al. (author) Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs 2004 In: BMC cell biology. - : Springer Science and Business Media LLC. - 1471-2121. ; 5:1, s. 42- Journal article (peer-reviewed)
6.	Uhrbom, Lene, et al. (author) Dissecting tumor maintenance requirements using bioluminescence imaging of cell proliferation in a mouse glioma model. 2004 In: Nat Med. - 1078-8956. ; 10:11, s. 1257-60 Journal article (peer-reviewed)
7.	Uhrbom, Lene, et al. (author) Modeling gliomagenesis with somatic cell gene transfer using retroviral vectors. 2001 In: J Neurooncol. - 0167-594X. ; 53:3, s. 297-305 Research review (pop. science, debate, etc.)
8.	Uhrbom, Lene, et al. (author) Somatic cell gene transfer 2004 In: Mouse Models Of Human Cancer. - : Wiley-Liss, Inc., Hoboken, New Jersey. - 047144460X ; , s. 474- Book chapter (other academic/artistic)
9.	Wolf, Rebecca M., et al. (author) p190RhoGAP can act to inhibit PDGF-induced gliomas in mice : a putative tumor suppressor encoded on human chromosome 19q13.3. 2003 In: Development, Genes and Evolution. - : Cold Spring Harbor Laboratory. - 0949-944X .- 1432-041X. ; 17:4, s. 476-487 Journal article (peer-reviewed)abstract p190RhoGAP and Rho are key regulators of oligodendrocyte differentiation. The gene encoding p190RhoGAP is located at 19q13.3 of the human chromosome, a locus that is deleted in 50%-80% of oligodendrogliomas. Here we provide evidence that p190RhoGAP may suppress gliomagenesis by inducing a differentiated glial phenotype. Using a cell culture model of autocrine loop PDGF stimulation, we show that reduced Rho activity via p190RhoGAP overexpression or Rho kinase inhibition induced cellular process extension, a block in proliferation, and reduced expression of the neural precursor marker nestin. In vivo infection of mice with retrovirus expressing PDGF and the p190 GAP domain caused a decreased incidence of oligodendrogliomas compared with that observed with PDGF alone. Independent experiments revealed that the retroviral vector insertion site in 3 of 50 PDGF-induced gliomas was within the p190RhoGAP gene. This evidence strongly suggests that p190 regulates critical components of PDGF oncogenesis and can act as a tumor suppressor in PDGF-induced gliomas by down-regulating Rho activity.

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Result 1-9 of 9

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Type of publication: journal article (5); book chapter (3); research review (1)

Type of content: peer-reviewed (5); other academic/artistic (3); pop. science, debate, etc. (1)

Author/Editor: Uhrbom, Lene (6); Holland, Eric C. (5); Fuller, Gregory N (2); Dai, Chengkai (2); Lien, A. Y. (1); Casanova, JL (1); show more...; Picard, C (1); Shaw, CA (1); Westermark, Bengt (1); Smith, CIE (1); Allen, C (1); Austin, A.T. (1); Ivanov, M. V. (1); Howarth, R.W. (1); Baron, J.S. (1); Chapin III, F.S. (1); Christensen, Torben (1); Holland, E.A. (1); Matinelli, L.A. (1); Melillo, J.M. (1); Shang, C. (1); J.M., Melillo (1); C., Field (1); B., Moldan (1); Holland, SM (1); Begemann, Martin (1); Rajasekhar, VK (1); Fieschi, C (1); Sollerbrant, K (1); Dupuis, S (1); Eklöf, Charlotta (1); Holland, PC (1); Sinnreich, M (1); Karpati, G (1); Nalbantoglu, J (1); Holland, E C (1); Nerio, Edward (1); Celestino, Joseph C (1); Rosenblum, Marc K (1); Wolf, Rebecca M. (1); Draghi, Nicole (1); Liang, Xiquan (1); Resh, Marilyn D. (1); show less...

University: Uppsala University (6); Karolinska Institutet (2); Lund University (1)

Language: English (9)

Research subject (UKÄ/SCB): Natural sciences (1)

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