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1.	Abbafati, C, et al. (author) Five insights from the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 396:10258, s. 1135-1159 Journal article (peer-reviewed)
2.	Abbafati, Cristiana, et al. (author) 2020 Journal article (peer-reviewed)
3.	Wang, HD, et al. (author) Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 2020 In: Lancet (London, England). - 1474-547X .- 0140-6736. ; 396:10258, s. 1160-1203 Journal article (peer-reviewed)
4.	Nerstedt, Annika, 1960, et al. (author) Lipid droplet-associated kinase STK25 regulates peroxisomal activity and metabolic stress response in steatotic liver 2020 In: Journal of Lipid Research. - 0022-2275. ; 61:2, s. 178-191 Journal article (peer-reviewed)abstract Nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are emerging as leading causes of liver disease worldwide and have been recognized as one of the major unmet medical needs of the 21st century. Our recent translational studies in mouse models, human cell lines, and well-characterized patient cohorts have identified serine/threonine kinase (STK)25 as a protein that coats intrahepatocellular lipid droplets (LDs) and critically regulates liver lipid homeostasis and progression of NAFLD/NASH. Here, we studied the mechanism-of-action of STK25 in steatotic liver by relative quantification of the hepatic LD-associated phosphoproteome from high-fat diet-fed Stk25 knockout mice compared with their wild-type littermates. We observed a total of 131 proteins and 60 phosphoproteins that were differentially represented in STK25-deficient livers. Most notably, a number of proteins involved in peroxisomal function, ubiquitination-mediated proteolysis, and antioxidant defense were coordinately regulated in Stk25(-/-) versus wild-type livers. We confirmed attenuated peroxisomal biogenesis and protection against oxidative and ER stress in STK25-deficient human liver cells, demonstrating the hepatocyte-autonomous manner of STK25's action. In summary, our results suggest that regulation of peroxisomal function and metabolic stress response may be important molecular mechanisms by which STK25 controls the development and progression of NAFLD/NASH.

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Type of publication: journal article (4)

Type of content: peer-reviewed (4)

Author/Editor: Park, J (2); Gupta, R. (2); Martini, S. (2); Rezaei, N (2); Kumar, P. (2); Tonelli, M. (2); show more...; Han, C. (2); Abbas, KM (2); Abbasifard, M (2); Abbasi-Kangevari, M (2); Abbastabar, H (2); Abd-Allah, F (2); Abdelalim, A (2); Abolhassani, H (2); Abreu, LG (2); Abrigo, MRM (2); Abushouk, AI (2); Adabi, M (2); Adair, T (2); Adebayo, OM (2); Adedeji, IA (2); Adekanmbi, V (2); Adeoye, AM (2); Adetokunboh, OO (2); Advani, SM (2); Afshin, A (2); Aghaali, M (2); Agrawal, A (2); Ahmadi, K (2); Ahmadieh, H (2); Ahmed, MB (2); Al-Aly, Z (2); Alam, K (2); Alam, T (2); Alanezi, FM (2); Alanzi, TM (2); Alcalde-Rabanal, JE (2); Ali, M (2); Alicandro, G (2); Alijanzadeh, M (2); Alinia, C (2); Alipour, V (2); Alizade, H (2); Aljunid, SM (2); Allebeck, P (2); Almadi, MAH (2); Almasi-Hashiani, A (2); Al-Mekhlafi, HM (2); Altirkawi, KA (2); Alumran, AK (2); show less...

University: Uppsala University (3); Karolinska Institutet (3); Högskolan Dalarna (3); University of Gothenburg (2)

Language: English (4)

Research subject (UKÄ/SCB): Medical and Health Sciences (3); Natural sciences (1)

Year: 2020 (4)Undo refine

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