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1.	Jakobsson, J., et al. (author) Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 2021 In: Autophagy. - : Informa UK Limited. - 1554-8635 .- 1554-8627. ; 17:1, s. 1-382 Journal article (peer-reviewed)
2.	Niemi, MEK, et al. (author) 2021 swepub:Mat__t
3.	Nogueira, RG, et al. (author) Global Impact of COVID-19 on Stroke Care and IV Thrombolysis 2021 In: Neurology. - 1526-632X. ; 96:23, s. E2824-E2838 Journal article (peer-reviewed)
4.	2021 swepub:Mat__t
5.	Buske, C, et al. (author) ASPEN: Results of a phase 3 randomized trial of zanubrutinib versus ibrutinib for patients with Waldenstrom Macroglobulinemia (WM) 2021 In: ONCOLOGY RESEARCH AND TREATMENT. - 2296-5270. ; 106:10, s. 9-10 Conference paper (other academic/artistic)
6.	Tang, J, et al. (author) Cancer cells escape p53's tumor suppression through ablation of ZDHHC1-mediated p53 palmitoylation 2021 In: Oncogene. - : Springer Science and Business Media LLC. - 1476-5594 .- 0950-9232. ; 40:35, s. 5416-5426 Journal article (peer-reviewed)abstract The inactivation of tumor-suppressor genes contributes heavily to oncogenesis. The mutation of TP53 has been well-studied and recognized as a major factor in the development of tumors. Yet other means of p53 inactivation has not been well-elucidated. We previously identified a hypermethylated gene ZDHHC1 that suppresses tumor growth when the expression was restored, but the specific mechanism was yet to be found. The protein product of ZDHHC1 is an S-palmitoyltransferase and we have identified p53 as a substrate for ZDHHC1-mediated palmitoylation, specifically at the C135, C176, and C275 residues. The novel form of post-translational modification of p53 is required for the nuclear translocation of the tumor suppressor. p53 recruited DNMT3A to ZDHHC1 promoter and is responsible for the hypermethylation of ZDHHC1. The epigenetic feedback loop formed by ZDHHC1 and p53 sheds light on the inactivation of p53 without the presence of genetic mutations.

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Result 1-6 of 6

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Type of publication: journal article (3); conference paper (1)

Type of content: peer-reviewed (3); other academic/artistic (1)

Author/Editor: Wang, H. (3); Zhang, H. (3); Hussain, S. (3); Singh, A (3); Liu, X (2); Chen, L (2); show more...; Chen, S. (2); Clark, A. (2); Gupta, S. (2); Huang, Y. (2); Lewis, A. (2); Wang, C. (2); Wang, K. (2); Wu, M. (2); Yang, Y. (2); Lange, C. (2); Davies, E. (2); Haider, S. (2); Banerjee, S. (2); Gupta, A. (2); Li, J. (2); Smith, M. (2); Martin, J. (2); Davies, G (2); Kumar, S (2); Brown, A. (2); Brown, E. (2); Sharma, S. (2); Evans, A. (2); Jones, M. (2); Kumar, A. (2); Yoshida, T. (2); Gomez, R. (2); Gupta, R. (2); Singh, R. (2); Wang, Y. (2); Davies, R (2); Schneider, J. (2); Chung, S. (2); Jones, R. (2); Khan, A. (2); Lee, M (2); Thomas, E. (2); Ali, M (2); Ali, S (2); Biondi, A (2); Khan, M (2); Smith, A (2); Russo, R. (2); Shah, R. (2); show less...

University: Karolinska Institutet (5); Umeå University (1); Stockholm University (1); Linköping University (1); Lund University (1); Swedish University of Agricultural Sciences (1)

Language: English (6)

Research subject (UKÄ/SCB): Medical and Health Sciences (2); Natural sciences (1)

Year: 2021 (6)Undo refine

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