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1.	Szarek, M, et al. (author) Alirocumab Reduces Total Hospitalizations and Increases Days Alive and Out of Hospital in the ODYSSEY OUTCOMES Trial 2019 In: Circulation. Cardiovascular quality and outcomes. - : Ovid Technologies (Wolters Kluwer Health). - 1941-7705 .- 1941-7713. ; 12:11, s. e005858- Journal article (peer-reviewed)
2.	Ray, KK, et al. (author) Effects of alirocumab on cardiovascular and metabolic outcomes after acute coronary syndrome in patients with or without diabetes: a prespecified analysis of the ODYSSEY OUTCOMES randomised controlled trial 2019 In: The lancet. Diabetes & endocrinology. - 2213-8595 .- 2213-8587. ; 7:8, s. 618-628 Journal article (peer-reviewed)
3.	Jukema, JW, et al. (author) Alirocumab in Patients With Polyvascular Disease and Recent Acute Coronary Syndrome: ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1167-1176 Journal article (peer-reviewed)
4.	Roe, MT, et al. (author) Risk Categorization Using New American College of Cardiology/American Heart Association Guidelines for Cholesterol Management and Its Relation to Alirocumab Treatment Following Acute Coronary Syndromes 2019 In: Circulation. - : Ovid Technologies (Wolters Kluwer Health). - 1524-4539 .- 0009-7322. ; 140:19, s. 1578-1589 Journal article (peer-reviewed)
5.	Szarek, M, et al. (author) Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events: The ODYSSEY OUTCOMES Trial 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 73:4, s. 387-396 Journal article (peer-reviewed)
6.	Bittner, VA, et al. (author) Effect of Alirocumab on Lipoprotein(a) and Cardiovascular Risk After Acute Coronary Syndrome 2020 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 75:2, s. 133-144 Journal article (peer-reviewed)
7.	Goodman, SG, et al. (author) Effects of Alirocumab on Cardiovascular Events After Coronary Bypass Surgery 2019 In: Journal of the American College of Cardiology. - : Elsevier BV. - 1558-3597 .- 0735-1097. ; 74:9, s. 1177-1186 Journal article (peer-reviewed)
8.	Schwartz, GG, et al. (author) Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome 2018 In: The New England journal of medicine. - : MASSACHUSETTS MEDICAL SOC. - 1533-4406 .- 0028-4793. ; 379:22, s. 2097-2107 Journal article (peer-reviewed)
9.	Bryois, J., et al. (author) Genetic identification of cell types underlying brain complex traits yields insights into the etiology of Parkinson’s disease 2020 In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 52:5, s. 482-493 Journal article (peer-reviewed)abstract Genome-wide association studies have discovered hundreds of loci associated with complex brain disorders, but it remains unclear in which cell types these loci are active. Here we integrate genome-wide association study results with single-cell transcriptomic data from the entire mouse nervous system to systematically identify cell types underlying brain complex traits. We show that psychiatric disorders are predominantly associated with projecting excitatory and inhibitory neurons. Neurological diseases were associated with different cell types, which is consistent with other lines of evidence. Notably, Parkinson’s disease was genetically associated not only with cholinergic and monoaminergic neurons (which include dopaminergic neurons) but also with enteric neurons and oligodendrocytes. Using post-mortem brain transcriptomic data, we confirmed alterations in these cells, even at the earliest stages of disease progression. Our study provides an important framework for understanding the cellular basis of complex brain maladies, and reveals an unexpected role of oligodendrocytes in Parkinson’s disease. © 2020, The Author(s), under exclusive licence to Springer Nature America, Inc.
10.	Locke, Adam E, et al. (author) Genetic studies of body mass index yield new insights for obesity biology. 2015 In: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 518:7538, s. 197-401 Journal article (peer-reviewed)abstract Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P < 5 × 10(-8)), 56 of which are novel. Five loci demonstrate clear evidence of several independent association signals, and many loci have significant effects on other metabolic phenotypes. The 97 loci account for ∼2.7% of BMI variation, and genome-wide estimates suggest that common variation accounts for >20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.

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Type of publication: journal article (47)

Type of content: peer-reviewed (47)

Author/Editor: Ohlsson, Claes, 1965 (14); Mahajan, A. (12); Groop, Leif (12); Salomaa, Veikko (12); Jukema, JW (12); Boehnke, Michael (12); show more...; Loos, Ruth J F (12); Hayward, Caroline (12); Lorentzon, Mattias, ... (11); Campbell, Harry (11); Luan, Jian'an (11); Eriksson, Johan G. (11); Hofman, Albert (11); Cupples, L. Adrienne (11); Vandenput, Liesbeth, ... (10); Perola, Markus (10); Rudan, Igor (10); Wareham, Nicholas J. (10); van Duijn, Cornelia ... (10); Ingelsson, Erik (10); Thorleifsson, Gudmar (10); Thorsteinsdottir, Un ... (10); Stefansson, Kari (10); Mangino, Massimo (10); Gieger, Christian (10); Wilson, James F. (10); Gudnason, Vilmundur (10); Guo, Y (9); Deloukas, Panos (9); Huber, K (9); North, Kari E. (9); Johansson, Åsa (9); McCarthy, Mark I (9); Mohlke, Karen L (9); Ripatti, Samuli (9); Abecasis, Goncalo R. (9); Wichmann, H. Erich (9); Martin, Nicholas G. (9); Larsen, J (9); Gyllensten, Ulf (9); Metspalu, A (9); Wright, Alan F. (9); Rivadeneira, Fernand ... (9); Harris, Tamara B (9); Uitterlinden, André ... (9); Hirschhorn, Joel N. (9); McKnight, Barbara (9); Boerwinkle, Eric (9); Sandhu, M. (9); de Silva, HA (9); show less...

University: Karolinska Institutet (35); University of Gothenburg (28); Uppsala University (25); Lund University (22); Umeå University (13); Högskolan Dalarna (3); show more...; Örebro University (2); show less...

Language: English (46); German (1)

Research subject (UKÄ/SCB): Medical and Health Sciences (47); Natural sciences (2)

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