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- Mufti, A.A., et al.
(author)
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New Canadian highway bridge design code design provisions for fibre-reinforced structures
- 2007
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In: Canadian journal of civil engineering (Print). - 0315-1468 .- 1208-6029. ; 34:3, s. 267-283
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Journal article (peer-reviewed)abstract
- This paper presents a synthesis of the design provisions of the second edition of the Canadian Highway Bridge Design Code (CHBDC) for fibre-reinforced structures. New design provisions for applications not covered by the first edition of the CHBDC and the rationale for those that remain unchanged from the first edition are given. Among the new design provisions are those for glass-fibre-reinforced polymer as both primary reinforcement and tendons in concrete; and for the rehabilitation of concrete and timber structures with externally bonded fibre-reinforced-polymer (FRP) systems or near-surface-mounted reinforcement. The provisions for fibre-reinforced concrete deck slabs in the first edition have been reorganized in the second edition to explicitly include deck slabs of both cast-in-place and precast construction and are now referred to as externally restrained deck slabs, whereas deck slabs containing internal FRP reinforcement are referred to as internally restrained deck slabs. Resistance factors in the second edition have been recast from those in the first edition and depend on the condition of use, with a further distinction made between factory- and field-produced FRP. In the second edition, the deformability requirements for FRP-reinforced and FRP-prestressed concrete beams and slabs of the first edition have been split into three subclauses covering the design for deformability, minimum flexural resistance, and crack-control reinforcement. The effect of sustained loads on the strength of FRPs is accounted for in the second edition by limits on stresses in FRP at the serviceability limit state.
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- Neale, David B, et al.
(author)
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Population, quantitative and comparative genomics of adaptation in forest trees
- 2008
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In: Current opinion in plant biology. - : Elsevier. - 1369-5266 .- 1879-0356. ; 11:2, s. 149-155
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Journal article (peer-reviewed)abstract
- High-throughput DNA sequencing and genotyping technologies have enabled a new generation of research in plant genetics where combined quantitative and population genetic approaches can be used to better understand the relationship between naturally occurring genotypic and phenotypic diversity. Forest trees are highly amenable to such studies because of their combined undomesticated and partially domesticated state. Forest geneticists are using association genetics to dissect complex adaptive traits and discover the underlying genes. In parallel, they are using resequencing of candidate genes and modern population genetics methods to discover genes under natural selection. This combined approach is identifying the most important genes that determine patterns of complex trait adaptation observed in many tree populations.
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- Nilsson, Jonas A, et al.
(author)
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Targeting ornithine decarboxylase in Myc-induced lymphomagenesis prevents tumor formation.
- 2005
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In: Cancer Cell. - 1535-6108. ; 7:5, s. 433-44
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Journal article (peer-reviewed)abstract
- Checkpoints that control Myc-mediated proliferation and apoptosis are bypassed during tumorigenesis. Genes encoding polyamine biosynthetic enzymes are overexpressed in B cells from E mu-Myc transgenic mice. Here, we report that disabling one of these Myc targets, Ornithine decarboxylase (Odc), abolishes Myc-induced suppression of the Cdk inhibitors p21(Cip1) and p27(Kip1), thereby impairing Myc's proliferative, but not apoptotic, response. Moreover, lymphoma development was markedly delayed in E mu-Myc;Odc(+/-) transgenic mice and in E mu-Myc mice treated with the Odc inhibitor difluoromethylornithine (DFMO). Strikingly, tumors ultimately arising in E mu-Myc;Odc(+/-) transgenics lacked deletions of Arf, suggesting that targeting Odc forces other routes of transformation. Therefore, Odc is a critical Myc transcription target that regulates checkpoints that guard against tumorigenesis and is an effective target for cancer chemoprevention.
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