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- Gusev, A, et al.
(author)
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Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation
- 2016
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7, s. 10979-
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Journal article (peer-reviewed)abstract
- Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data from 59,089 men of European and African American ancestries combined with cell-type-specific epigenetic data to build a genomic atlas of single-nucleotide polymorphism (SNP) heritability in PrCa. We find significant differences in heritability between variants in prostate-relevant epigenetic marks defined in normal versus tumour tissue as well as between tissue and cell lines. The majority of SNP heritability lies in regions marked by H3k27 acetylation in prostate adenoc7arcinoma cell line (LNCaP) or by DNaseI hypersensitive sites in cancer cell lines. We find a high degree of similarity between European and African American ancestries suggesting a similar genetic architecture from common variation underlying PrCa risk. Our findings showcase the power of integrating functional annotation with genetic data to understand the genetic basis of PrCa.
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| 4. |
- Niwa, T., et al.
(author)
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Universal fault detection for NFV using SOM-based clustering
- 2015
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In: 17th Asia-Pacific Network Operations and Management Symposium. - : IEEE. - 9784885522963 ; , s. 315-320
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Conference paper (peer-reviewed)abstract
- Network function virtualization (NFV) introduces additional complexity to network management, since the placement and behavior of virtualized network functions (VNFs) can be independent from the underlying hardware, and virtualization technology increases the number of monitoring points and the amount of statistical data. In our previous work, we proposed a framework for detecting anomalous behavior of VNFs using a SOM-based technique. The solution relies upon manually configuring the SOM clustering parameters and selecting the statistics for each failure type in advance, which results in a high maintenance load. In this paper, we provide a solution that is universal in the sense that a range of different faults can be detected using a single set of local statistics and SOM clustering parameters. Experimental results from a testbed show that faults, including memory leak, packet congestion, and session congestion, can be detected with high accuracy using only four types of performance statistics.
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| 6. |
- Harada, Y., et al.
(author)
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Probing the OH Stretch in Different Local Environments in Liquid Water
- 2017
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In: The Journal of Physical Chemistry Letters. - : American Chemical Society (ACS). - 1948-7185. ; 8:22, s. 5487-5491
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Journal article (peer-reviewed)abstract
- We use resonant inelastic X-ray scattering (RIXS) to resolve vibrational losses corresponding to the OH stretch where the X-ray absorption process allows us to selectively probe different structural subensembles in liquid water. The results point to a unified interpretation of X-ray and vibrational spectroscopic data in line with a picture of two classes of structural environments in the liquid at ambient conditions with predominantly close-packed high-density liquid (HDL) and occasional local fluctuations into strongly tetrahedral low-density liquid (LDL).
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