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Search: (WFRF:(Ogawa M)) srt2:(2000-2004) > (2003)

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  • Garey, J, et al. (author)
  • Genetic contributions to generalized arousal of brain and behavior
  • 2003
  • In: Proceedings of the National Academy of Sciences of the United States of America. - : Proceedings of the National Academy of Sciences. - 0027-8424. ; 100:19, s. 11019-11022
  • Journal article (peer-reviewed)abstract
    • We have identified a generalized arousal component in the behavior of mice. Analyzed by mathematical/statistical approaches across experiments, investigators, and mouse populations, it accounts for about 1/3 of the variance in arousal-related measures. Knockout of the gene coding for the classical estrogen receptor (ER-α), a ligand-activated transcription factor, greatly reduced arousal responses. In contrast, disrupting the gene for a likely gene duplication product, ER-β, did not have these effects. A combination of mathematical and genetic approaches to arousal in an experimentally tractable mammal opens up analysis of a CNS function of considerable theoretical and practical significance.
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  • Result 1-2 of 2
Type of publication
journal article (2)
Type of content
peer-reviewed (2)
Author/Editor
Ogawa, T. (1)
Ogawa, S. (1)
Morgan, M (1)
Gustafsson, JA (1)
Linder, S (1)
Toi, M (1)
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Frohlich, J (1)
Korach, KS (1)
Biven, K (1)
Ueno, T (1)
Pfaff, DW (1)
Garey, J (1)
Goodwillie, A (1)
Smithies, O (1)
Bando, H (1)
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University
Karolinska Institutet (2)
Language
English (2)
Year

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