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1.	Marshall, CR, et al. (author) Contribution of copy number variants to schizophrenia from a genome-wide study of 41,321 subjects 2017 In: Nature genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 49:1, s. 27-35 Journal article (peer-reviewed)
2.	McLaughlin, RL, et al. (author) Genetic correlation between amyotrophic lateral sclerosis and schizophrenia 2017 In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8, s. 14774- Journal article (peer-reviewed)abstract We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05–21.6; P=1 × 10−4) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P=8.4 × 10−7). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08–1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.

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Type of publication: journal article (2)

Type of content: peer-reviewed (2)

Author/Editor: Ophoff, RA (2); Kahn, RS (2); Williams, S. (1); Kim, Y. (1); Alexander, M. (1); Agartz, I (1); show more...; Andreassen, OA (1); Melle, I (1); Djurovic, S (1); Mallet, J. (1); Ikeda, M. (1); Powell, J (1); MCDONALD, C (1); Corvin, A (1); Gurling, H (1); Pato, CN (1); Pato, MT (1); Craddock, N (1); Kirov, G (1); Rujescu, D (1); St Clair, D (1); Werge, T (1); Hultman, CM (1); Delisi, LE (1); Stroup, TS (1); Webb, BT (1); Sebat, J (1); Fanous, AH (1); Magnusson, PKE (1); Cheng, W. (1); Giusti-Rodriguez, P (1); Cohen, D (1); Kavanagh, D (1); Mattheisen, M (1); Van Eijk, KR (1); Buckner, RL (1); Cahn, W (1); Cichon, S (1); Crespo-Facorro, B (1); Donohoe, G (1); Hofman, A (1); Jonsson, EG (1); McIntosh, AM (1); Morris, DW (1); Muller-Myhsok, B (1); Nothen, MM (1); Rietschel, M (1); Roffman, JL (1); Smoller, JW (1); Levinson, DF (1); show less...

University: Karolinska Institutet (2); Umeå University (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (1)

Year: 2017 (2)Undo refine

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