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Träfflista för sökning "(WFRF:(Palosuo T)) srt2:(2020-2023) "

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1.	Bousquet, J, et al. (author) Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis 2023 In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 78:5, s. 1169-1203 Journal article (peer-reviewed)
2.	Bousqvet, J, et al. (author) Rhinitis associated with asthma is distinct from rhinitis alone: The ARIA-MeDALL hypothesis 2023 In: Allergy. - : Wiley. - 1398-9995 .- 0105-4538. ; 78:5, s. 1169-1203 Journal article (peer-reviewed)
3.	Dramburg, S, et al. (author) EAACI Molecular Allergology User's Guide 2.0 2023 In: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. - 1399-3038. ; 3434 Suppl 28, s. e13854- Journal article (peer-reviewed)
4.	Hinkkanen, V, et al. (author) Oral immunotherapy modifies antigen-specific antibodies in serum and protein production in blood mononuclear cells in egg allergic children 2023 In: ALLERGY. - 0105-4538. ; 78 Conference paper (other academic/artistic)
5.	Karisola, P, et al. (author) Integrative Transcriptomics Reveals Activation of Innate Immune Responses and Inhibition of Inflammation During Oral Immunotherapy for Egg Allergy in Children 2021 In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 12, s. 704633- Journal article (peer-reviewed)abstract We previously reported the results of a randomized, open-label trial of egg oral immunotherapy (OIT) in 50 children where 44% were desensitized and 46% were partially desensitized after 8 months of treatment. Here we focus on cell-mediated molecular mechanisms driving desensitization during egg OIT. We sought to determine whether changes in genome-wide gene expression in blood cells during egg OIT correlate with humoral responses and the clinical outcome. The blood cell transcriptome of 50 children receiving egg OIT was profiled using peripheral blood mononuclear cell (PBMC) samples obtained at baseline and after 3 and 8 months of OIT. We identified 467 differentially expressed genes (DEGs) after 3 or 8 months of egg OIT. At 8 months, 86% of the DEGs were downregulated and played a role in the signaling of TREM1, IL-6, and IL-17. In correlation analyses, Gal d 1–4-specific IgG4 antibodies associated positively with DEGs playing a role in pathogen recognition and antigen presentation and negatively with DEGs playing a role in the signaling of IL-10, IL-6, and IL-17. Desensitized and partially desensitized patients had differences in their antibody responses, and although most of the transcriptomic changes were shared, both groups had also specific patterns, which suggest slower changes in partially desensitized and activation of NK cells in the desensitized group. OIT for egg allergy in children inhibits inflammation and activates innate immune responses regardless of the clinical outcome at 8 months. Changes in gene expression patterns first appear as posttranslational protein modifications, followed by more sustained epigenetic gene regulatory functions related to successful desensitization.
6.	Palosuo, K, et al. (author) A Randomized, Open-Label Trial of Hen's Egg Oral Immunotherapy: Efficacy and Humoral Immune Responses in 50 Children 2021 In: The journal of allergy and clinical immunology. In practice. - : Elsevier BV. - 2213-2201 .- 2213-2198. ; 9:5, s. 1892- Journal article (peer-reviewed)

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Type of publication: journal article (5); conference paper (1)

Type of content: peer-reviewed (5); other academic/artistic (1)

Author/Editor: Caraballo, L (3); Karisola, P (3); Alenius, H (3); van Hage, M (3); Jutel, M (3); Wickman, M (3); show more...; Williams, S. (2); Zhang, L. (2); Sunyer, J (2); Heinrich, J. (2); Mohammad, Y (2); Sheikh, A (2); Bush, A (2); Ohta, K. (2); Costa, E. (2); Anto, JM (2); Makris, M. (2); Bernstein, D (2); Melen, E (2); Jartti, T (2); Valenta, R (2); Agache, I (2); Akdis, M (2); Chivato, T (2); del Giacco, S (2); Eiwegger, T (2); Maurer, M (2); Palomares, O (2); Hofmann, M. (2); Kull, I (2); Aguilar, D (2); Koppelman, GH (2); Garcia-Aymerich, J (2); Guerra, S (2); Keil, T (2); Lemonnier, N (2); Bustamante, M (2); Celedón, JC (2); Brightling, CE (2); Halken, S (2); Ring, J. (2); Vichyanond, P (2); Standl, M (2); Thomas, M (2); Akdis, CA (2); Bindslev-Jensen, C (2); Zuberbier, T (2); Cingi, C (2); Al-Ahmad, M (2); Pfaar, O (2); show less...

University: Karolinska Institutet (6)

Language: English (6)

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