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- Hedenstedt, Anna, et al.
(author)
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B cell polygenic risk scores associate with anti-dsDNA antibodies and nephritis in systemic lupus erythematosus.
- 2023
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In: Lupus science & medicine. - : BMJ Publishing Group Ltd. - 2053-8790. ; 10:2
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Journal article (peer-reviewed)abstract
- B cell function and autoantibodies are important in SLE pathogenesis. In this work, we aimed to investigate the impact of cumulative SLE B cell genetics on SLE subphenotype and autoantibody profile.Female patients with SLE (n=1248) and healthy controls (n=400) were genotyped using Illumina's Global Screening Array. Two polygenic risk scores (PRSs), one representing B cell genes and the other B cell activation genes, were calculated for each individual using risk loci for SLE in genes assigned to B cell-related pathways according to the Kyoto Encyclopedia of Genes and Genomes, Gene Ontology and Reactome Databases.Double-stranded DNA (dsDNA) antibodies were more prevalent among patients with a high compared with a low SLE B cell PRS (OR 1.47 (1.07 to 2.01), p=0.018), and effect sizes were augmented in patients with human leucocyte antigen (HLA) risk haplotypes HLA-DRB1*03:01 and HLA-DRB1*15:01 (DRB1*03/15 -/- (OR 0.99 (0.56 to 1.77), p=0.98; DRB1*03/15 +/- or -/+ (OR 1.64 (1.06 to 2.54), p=0.028; and DRB1*03/15 +/+ (OR 4.47 (1.21 to 16.47), p=0.024). Further, a high compared with a low B cell PRS was associated with low complement levels in DRB1*03/15 +/+ patients (OR 3.92 (1.22 to 12.64), p=0.022). The prevalence of lupus nephritis (LN) was higher in patients with a B cell activation PRS above the third quartile compared with patients below (OR 1.32 (1.00 to 1.74), p=0.048).High genetic burden related to B cell function is associated with dsDNA antibody development and LN. Assessing B cell PRSs may be important in order to determine immunological pathways influencing SLE and to predict clinical phenotype.
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| 2. |
- Jardim, Fabiana, et al.
(author)
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Virus as a figure of geontopower or how to practice Foucault now? : A conversation with Elizabeth A. Povinelli
- 2023
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In: Foucault Studies. - : Copenhagen Business School Press. - 1832-5203. ; :35, s. 211-231
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Journal article (other academic/artistic)abstract
- Elizabeth A. Povinelli, Franz Boas Professor at Columbia University, is a philosopher and anthropologist who has critically engaged with Michel Foucault’s ideas as well as scholarship inspired by his works. Povinelli has been dedicated to research on colonialism within liberalism and is also a filmmaker and founding member of The Karrabing Film Collective. The film collective is part of a larger organization of Aboriginal peoples and artists living in the Australian Northern Territory that refuses ‘fantasies of sovereignty and property’.[1]As Povinelli shares with us during the interview, her trajectory was constituted in the middle of the 1980s following her life-changing encounter with the elders in Belyuen in the Australian Northern Territory. In the wake of that encounter, and with urgent issues raised about indigeneity due to changes in Australian law, Povinelli has been working even closer with her Karrabing family. The changes in law both acknowledged Aboriginal peoples' rights to their territory and imposed certain ideas of identity, family and culture, producing an entanglement between rights and government. These efforts to manage differences – cultural, race, gender – are problematized and deciphered in Povinelli’s ethnographic work with a focus on how late settler liberalism has been reconfigured with novel expressions of colonialism and imperialism.
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| 3. |
- Skoglund, Elisabeth, et al.
(author)
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Skeletal muscle morphology, satellite cells, and oxidative profile in relation to physical function and lifelong endurance training in very old men
- 2023
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In: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 134:2, s. 264-275
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Journal article (peer-reviewed)abstract
- In the current study, we compared muscle morphology in three advanced aging cohorts that differed in physical function, includ-ing a unique cohort of lifelong endurance athletes. Biopsies from the vastus lateralis muscle of seven lifelong endurance athletes (EAs) aged 82-92 yr, and 19 subjects from the Uppsala Longitudinal Study of Adult Men (ULSAM) aged 87-91 yr were analyzed. ULSAM subjects were divided into high-(n = 9, HF) and low-(n = 10, LF) function groups based on strength and physical function tests. The analysis included general morphology, fiber type and cross-sectional area, capillarization, deficient cytochrome c oxi-dase (COX) activity, number of myonuclei and satellite cells, and markers of regeneration and denervation. Fibers with central nuclei and/or nuclear clumps were observed in all groups. EA differed from LF and HF by having a higher proportion of type I fibers, 52% more capillaries in relation to fiber area, fewer COX-negative fibers, and less variation in fiber sizes (all P < 0.05). There were no differences between the groups in the number of myonuclei and satellite cells per fiber, and no significant differ-ences between LF and HF (P > 0.05). In conclusion, signs of aging were evident in the muscle morphology of all groups, but neither endurance training status nor physical function influenced signs of regeneration and denervation processes. Lifelong en-durance training, but not higher physical function, was associated with higher muscle oxidative capacity, even beyond the age of 80.NEW & NOTEWORTHY Here we show that lifelong endurance training, but not physical function, is associated with higher mus-cle oxidative capacity, even beyond the age of 80 yr. Neither endurance training status nor physical function was significantly associated with satellite cells or markers of regeneration and denervation in muscle biopsies from these very old men.
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