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1.	Baliakas, Panagiotis, et al. (author) Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. 2015 In: Blood. - : American Society of Hematology. - 1528-0020 .- 0006-4971. ; 125:5, s. 856-859 Journal article (peer-reviewed)abstract An unresolved issue in chronic lymphocytic leukemia (CLL) is whether IGHV3-21 gene usage, in general, or the expression of stereotyped B-cell receptor immunoglobulin defining subset #2 (IGHV3-21/IGLV3-21), in particular, determines outcome for IGHV3-21-utilizing cases. We reappraised this issue in 8593 CLL patients of whom 437 (5%) used the IGHV3-21 gene with 254/437 (58%) classified as subset #2. Within subset #2, immunoglobulin heavy variable (IGHV)-mutated cases predominated, whereas non-subset #2/IGHV3-21 was enriched for IGHV-unmutated cases (P = .002). Subset #2 exhibited significantly shorter time-to-first-treatment (TTFT) compared with non-subset #2/IGHV3-21 (22 vs 60 months, P = .001). No such difference was observed between non-subset #2/IGHV3-21 vs the remaining CLL with similar IGHV mutational status. In conclusion, IGHV3-21 CLL should not be axiomatically considered a homogeneous entity with adverse prognosis, given that only subset #2 emerges as uniformly aggressive, contrasting non-subset #2/IGVH3-21 patients whose prognosis depends on IGHV mutational status as the remaining CLL.
2.	Xochelli, Aliki, et al. (author) CLL with Mutated IGHV4-34 Antigen Receptors Is Clinically Heterogeneous : Antigen Receptor Stereotypy Makes the Difference 2015 In: Blood. - 0006-4971 .- 1528-0020. ; 126:23 Journal article (other academic/artistic)

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Type of publication: journal article (2)

Type of content: other academic/artistic (1); peer-reviewed (1)

Author/Editor: Smedby, Karin E. (2); Mansouri, Larry (2); Juliusson, Gunnar (2); Agathangelidis, Andr ... (2); Davi, Frederic (2); Langerak, Anton W. (2); show more...; Baliakas, Panagiotis (2); Stamatopoulos, Kosta ... (2); Scarfo, Lydia (2); Sutton, Lesley-Ann (2); Ghia, Paolo (2); Hadzidimitriou, Anas ... (2); Belessi, Chrysoula (2); Darzentas, Nikos (2); Davis, Zadie (2); Chu, Charles C. (2); Giudicelli, Veroniqu ... (2); Pedersen, Lone Bredo (2); Anagnostopoulos, Ach ... (2); Pospisilova, Sarka (2); Lefranc, Marie-Paule (2); Chiorazzi, Nicholas (2); Panagiotidis, Panagi ... (2); Plevova, Karla (2); Minga, Eva (2); Oscier, David (2); Sandberg, Yorick (2); Vojdeman, Fie Juhl (2); Boudjogra, Myriam (2); Tzenou, Tatiana (2); Chatzouli, Maria (2); Veronese, Silvio (2); Facco, Monica (2); Trentin, Livio (2); Catherwood, Mark (2); Montillo, Marco (2); Campo, Elias (1); Geisler, Christian H (1); Rosenquist, Richard (1); Yan, Xiao-Jie (1); Angelis, Lefteris (1); Xochelli, Aliki (1); Rosenquist, Richard ... (1); Nguyen-Khac, Florenc ... (1); Gardiner, Anne (1); Stavroyianni, Niki (1); Tsanousa, Athina (1); Shanafelt, Tait (1); van Lom, Kirsten (1); Francova, Hana Skuhr ... (1); show less...

University: Uppsala University (2); Lund University (1); Karolinska Institutet (1)

Language: English (2)

Research subject (UKÄ/SCB): Medical and Health Sciences (2)

Year: 2015 (2)Undo refine

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