| 1. |
- van Dijk, Marlous, 1990, et al.
(author)
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Strain-dependent variance in short-term adaptation effects of two xylose-fermenting strains of Saccharomyces cerevisiae
- 2019
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In: Bioresource technology. - : Elsevier BV. - 0960-8524 .- 1873-2976. ; 292, s. 121922-
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Journal article (peer-reviewed)abstract
- The limited tolerance of Saccharomyces cerevisiae to the inhibitors present in lignocellulosic hydrolysates is a major challenge in second-generation bioethanol production. Short-term adaptation of the yeast to lignocellulosic hydrolysates during cell propagation has been shown to improve its tolerance, and thus its performance in lignocellulose fermentation. The aim of this study was to investigate the short-term adaptation effects in yeast strains with different genetic backgrounds. Fed-batch propagation cultures were supplemented with 40% wheat straw hydrolysate during the feed phase to adapt two different pentose-fermenting strains, CR01 and KE6-12. The harvested cells were used to inoculate fermentation media containing 80% or 90% wheat straw hydrolysate. The specific ethanol productivity during fermentation was up to 3.6 times higher for CR01 and 1.6 times higher for KE6-12 following adaptation. The influence of physiological parameters such as viability, storage carbohydrate content, and metabolite yields following short-term adaptation demonstrated that short-term adaptation was strain dependent.
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| 2. |
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| 4. |
- van Dijk, Marten, et al.
(author)
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Unconditionally Secure Group Authentication
- 1998
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In: Designs, Codes, and Cryptography. - 0925-1022. ; 14, s. 281-296
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Journal article (peer-reviewed)abstract
- Group authentication schemes as introduced by Boyd and by Desmedt and Frankel are cryptographic schemes in which only certain designated groups can provide messages with authentication information. In this paper we study unconditionally secure group authentication schemes based on linear perfect secret sharing and authentication schemes, for which we give expressions for the probabilities of successful attacks. Furthermore, we give a construction that uses maximum rank distance codes.
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| 5. |
- Fava, Cristiano, et al.
(author)
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Dipping and variability of blood pressure and heart rate at night are heritable traits.
- 2005
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In: American Journal of Hypertension. - : Oxford University Press (OUP). - 1941-7225 .- 0895-7061. ; 18:11, s. 1402-1407
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Conference paper (peer-reviewed)abstract
- Background: Blunted nocturnal blood pressure dipping (NBPD) as well as high variability in blood pressure (BPV) and low variability in heart rate (HRV), are associated with increased cardiovascular morbidity and mortality. The aim of this study was to determine whether these traits are heritable. Methods: We studied 260 healthy siblings without antihypertensive drugs from 118 Swedish families. The BPV and HRV were defined as the standard deviation of BP and heart rate values recorded during 24 h, daytime (6 AM to 10 Pm), and night-time (10 Pm to 6 AM). The NBPD was defined as the ratio between night-time and daytime BP. Heritability was estimated with a maximal likelihood method implemented in the Solar software package with and without adjustment for significant covariates. Results: At night, significant heritability was found for systolic (33%, P <.05), diastolic (36%, P <.05), and mean (42%, P <.01) BPV. After covariate adjustment the corresponding heritability values were 23% (P =.08), 29% (P <.05), and 37% (P <.05). Daytime BPV was not heritable. The heritability of NBPD was 38% (P <.05) for systolic, 9% (P =.29) for diastolic, and 36% (P <.05) for mean BP, but after adjustment only systolic NBPD was significant (29%, P <.05). Heart rate was highly heritable both during daytime (57%, P <.001) and night-time (58%, P <.001), but the variability of heart rate, after adjustment, was only significant at night (37%, P <.05). Conclusions: Our data suggest that BPV and HRV are partially under genetic control and that genetic loci of importance for these traits could be mapped by linkage analysis. Am J Hypertens 2005;18:1402-1407 0 2005 American Journal of Hypertension, Ltd.
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| 6. |
- Fava, Cristiano, et al.
(author)
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From circulating biomarkers to genomics and imaging in the prediction of cardiovascular events in the general population.
- 2012
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In: Annals of Medicine. - : Informa UK Limited. - 1365-2060 .- 0785-3890. ; 44:5, s. 433-447
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Journal article (peer-reviewed)abstract
- Abstract Cardiovascular disease (CVD) is the leading cause of death and disability worldwide. In the last decades numerous markers have been considered and investigated for the prediction of CV events, but only a few of them resulted in improved global risk assessment beyond traditional risk factors when incorporated into coronary evaluation scores. Recent genetic studies have pointed out a few but consistent loci or genes which are independently associated with CV risk. The idea is fascinating that these genetic markers could lead to improved individual CV risk assessment and tailored pharmacological interventions. In this brief review we will not make a systematic review of all non-genetic and genetic markers of CV risk but we will try to make a brief overview of the most interesting ones with the aim to underline potential 'pros' and 'cons' of their implementation in clinical practice.
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