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- Özçetin, Seda
(creator_code:cre_t, designer, editor, creator_code:fmk_t, producer, creator_code:res_t, accompanying material, photographer, creator_code:vdg_t)
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Look, a ToSsphere! : Behind the checkbox of Terms of Service
- 2023
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Artistic workabstract
- In this project, I attempt to go behind the checkbox and unpack what is it that we agree on when we check ‘I have read and agree on ToS’ boxes. By engaging with ToS at different scales – zooming in and out – through reading, translating, and transposing, I explore what each mode of engagement reveals, what questions they lead to, and how these explorations could inform designers.
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| 4. |
- Öz, Robin, 1992, et al.
(author)
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Dynamics of Ku and bacterial non-homologous end-joining characterized using single DNA molecule analysis
- 2021
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In: Nucleic Acids Research. - : Oxford University Press (OUP). - 0305-1048 .- 1362-4962. ; 49:5, s. 2629-2641
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Journal article (peer-reviewed)abstract
- We use single-molecule techniques to characterize the dynamics of prokaryotic DNA repair by non-homologous end-joining (NHEJ), a system comprised only of the dimeric Ku and Ligase D (LigD). The Ku homodimer alone forms a ∼2 s synapsis between blunt DNA ends that is increased to ∼18 s upon addition of LigD, in a manner dependent on the C-terminal arms of Ku. The synapsis lifetime increases drastically for 4 nt complementary DNA overhangs, independently of the C-terminal arms of Ku. These observations are in contrast to human Ku, which is unable to bridge either of the two DNA substrates. We also demonstrate that bacterial Ku binds the DNA ends in a cooperative manner for synapsis initiation and remains stably bound at DNA junctions for several hours after ligation is completed, indicating that a system for removal of the proteins is active in vivo. Together these experiments shed light on the dynamics of bacterial NHEJ in DNA end recognition and processing. We speculate on the evolutionary similarities between bacterial and eukaryotic NHEJ and discuss how an increased understanding of bacterial NHEJ can open the door for future antibiotic therapies targeting this mechanism.
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| 5. |
- Özdemir, O., et al.
(author)
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Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells
- 2020
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In: Zeitschrift für Naturforschung C - A Journal of Biosciences. - : Walter de Gruyter GmbH. - 0939-5075 .- 1865-7125.
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Journal article (peer-reviewed)abstract
- Several epidemiologic, clinical and experimental reports indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) could have a potential as anticancer agents. The aim of this study was the evaluation of cytotoxic potential in human glioblastoma cells of novel synthesized NSAID derivatives, obtained by linking, through a spacer, α-lipoic acid (ALA) to anti-inflammatory drugs, such as naproxen (AL-3, 11 and 17), flurbiprofen (AL-6, 13 and 19) and ibuprofen (AL-9, 15 and 21). The effects on the level of gene expression were also determined using quantitative real-time polymerase chain reaction (qRT-PCR) analysis. According to our results, NSAID derivatives exhibited concentration dependent cytotoxic effects on U87-MG cell line when compared with the control group. Moreover, treatment of the most active compounds (AL-3, AL-6 and AL-9) caused upregulation of tumor suppressor gene PTEN and downregulation of some oncogenes such as AKT1, RAF1 and EGFR. In conclusion, our results revealed that AL-3, AL-6 and AL-9 could be suitable candidates for further investigation to develop new pharmacological strategies for the prevention of cancer.
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| 6. |
- Özkirimli, Umut
(author)
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Nationalism
- 2019
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In: Oxford Bibliographies.
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Journal article (peer-reviewed)
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- Özkul, Didem
(author)
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The algorithmic fix : Location intelligence, placemaking, and predictable futures
- 2021
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In: Convergence. The International Journal of Research into New Media Technologies. - : Sage Publications. - 1354-8565 .- 1748-7382. ; 27:3, s. 594-608
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Journal article (peer-reviewed)abstract
- With this article, I introduce the 'algorithmic fix' as a framework to analyze contemporary placemaking practices. I discuss how algorithmic practices of placemaking govern and control mobilities. I theorize such practices as the 'algorithmic fix', where location determination technologies, data practices, and machine learning algorithms are used together to 'get a fix on' our whereabouts with the aim of sorting and classifying both people and places. Through a case study of location intelligence, I demonstrate how these digital placemaking practices do not only control and prevent physical mobilities - they are designed to fix who we are and whom we may become with the aim of creating a predictable future. I focus on geo-profiling, geo-fencing, and predictive policing as three key aspects of location intelligence to present a discussion of how 'algorithmic fix' as a framework can provide valuable insights to analyzing contemporary placemaking practices.
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