| 1. |
- Hua, Kuo-Tai, et al.
(författare)
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N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity
- 2011
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Ingår i: Cancer Cell. - : Cell Press. - 1535-6108 .- 1878-3686. ; 19:2, s. 218-231
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Tidskriftsartikel (refereegranskat)abstract
- N-α-acetyltransferase 10 protein, Naa10p, is an N-acetyltransferase known to be involved in cell cycle control. We found that Naa10p was expressed lower in varieties of malignancies with lymph node metastasis compared with non-lymph node metastasis. Higher Naa10p expression correlates the survival of lung cancer patients. Naa10p significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity. Instead, Naa10p binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activity and decreased cell migration. Forced expression of PIX in Naa10-transfected tumor cells restored the migration and metastasis ability. We suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells.
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| 2. |
- Kilpeläinen, Tuomas O, et al.
(författare)
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Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children.
- 2011
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Ingår i: PLoS medicine. - : Public Library of Science (PLoS). - 1549-1676 .- 1549-1277. ; 8:11
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The FTO gene harbors the strongest known susceptibility locus for obesity. While many individual studies have suggested that physical activity (PA) may attenuate the effect of FTO on obesity risk, other studies have not been able to confirm this interaction. To confirm or refute unambiguously whether PA attenuates the association of FTO with obesity risk, we meta-analyzed data from 45 studies of adults (n=218,166) and nine studies of children and adolescents (n=19,268). METHODS AND FINDINGS: All studies identified to have data on the FTO rs9939609 variant (or any proxy [r(2)>0.8]) and PA were invited to participate, regardless of ethnicity or age of the participants. PA was standardized by categorizing it into a dichotomous variable (physically inactive versus active) in each study. Overall, 25% of adults and 13% of children were categorized as inactive. Interaction analyses were performed within each study by including the FTO×PA interaction term in an additive model, adjusting for age and sex. Subsequently, random effects meta-analysis was used to pool the interaction terms. In adults, the minor (A-) allele of rs9939609 increased the odds of obesity by 1.23-fold/allele (95% CI 1.20-1.26), but PA attenuated this effect (p(interaction) =0.001). More specifically, the minor allele of rs9939609 increased the odds of obesity less in the physically active group (odds ratio =1.22/allele, 95% CI 1.19-1.25) than in the inactive group (odds ratio =1.30/allele, 95% CI 1.24-1.36). No such interaction was found in children and adolescents. CONCLUSIONS: The association of the FTO risk allele with the odds of obesity is attenuated by 27% in physically active adults, highlighting the importance of PA in particular in those genetically predisposed to obesity.
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| 3. |
- Liu, Zhao-Di, et al.
(författare)
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Influence of the central metal on the crystal structures and electronic structures of biferrocene trinuclear complexes
- 2011
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Ingår i: Polyhedron. - : Elsevier. - 0277-5387 .- 1873-3719. ; 30:2, s. 279-283
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Tidskriftsartikel (refereegranskat)abstract
- Five metal-bridged biferrocene complexes of the Schiff-base ligand (HL = S-benzyl-N-(ferrocenyl-1-methyl-methylidene)dithiocarbazate) have been studied by single crystal X-ray diffraction and 57Fe Mössbauer spectroscopy. The crystal structures of the complexes show that the central metal ions are tetra-coordinated by two ligands in two modes: the central d8 transition metal ions (Ni2+, Pd2+, and Pt2+) are nearly square-planar coordinated and the d10 transition metal ions (Zn2+ and Cd2+) are tetrahedrally coordinated. Interestingly, the isomer shifts in 57Fe Mössbauer spectroscopy are also of two kinds: d8 transition metal ions (0.097–0.247 mm/s) and d10 transition metal ions (0.416–0.435 mm/s).
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| 4. |
- Wu, Ying, et al.
(författare)
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A 0.13µm CMOS ΔΣ PLL FM Transmitter
- 2011
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Ingår i: [Host publication title missing]. - 9781457705144
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Konferensbidrag (refereegranskat)abstract
- A short range FM transmitter is presented. It uses an architecture where the output frequency of a phase locked loop (PLL) is modulated by varying the division number of the feedback divider, using the 1-bit output of a ΔΣ ADC. The measured total harmonic distortion (THD) plus noise is less than 1% at 75 kHz deviation. The transmitter is fully integrated in a 0.13µm CMOS process and the core area is 0.24 mm2. The current consumption is 4.4mA from a 1.2V supply.
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| 5. |
- Wu, Ying, et al.
(författare)
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A Digital PLL with a Multi-Delay Coarse-Fine TDC
- 2011
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Ingår i: [Host publication title missing]. - 9781457705144
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Konferensbidrag (refereegranskat)abstract
- A 5GHz digital frequency synthesizer achieving a low noise for wireless RF application is presented. This architecture uses a multi-delay coarse-fine Time-to-Digital Converter (TDC) to achieve both the large detection range and fine resolution. A Digitally Controlled Oscillator (DCO) based on capacitive degeneration in LC-Tank is also implement-ed. The DCO achieves frequency quantization step of 300 Hz without any dithering. Simulated phase noise at 5 GHz carrier frequency is -125 and -151 dBc/Hz at 1 MHz and 20 MHz offset, respectively. The Digital phase-locked loop (DPLL) is realized in 90nm CMOS process and consumes 14mA from a 1.2V supply.
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| 6. |
- Zhang, Igor Ying, et al.
(författare)
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Accurate Bond Dissociation Enthalpies by Using Doubly Hybrid XYG3 Functional
- 2011
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Ingår i: Journal of Computational Chemistry. - : Wiley. - 0192-8651 .- 1096-987X. ; 32:9, s. 1824-1838
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Tidskriftsartikel (refereegranskat)abstract
- In this work, we examine the performance of XYG3, a newly developed doubly hybrid density functional (Zhang, Xu, and Goddard III, Proc Natl Acad Sci USA 2009, 106, 4963), to calculate covalent bond dissociation enthalpy (BDE). We use 5 atoms, 32 molecular radicals, and 116 closed-shell molecules to set up 142 bond dissociation reactions. For the total of 148 heats of formation (HOFs) and 142 BDEs, XYG3 leads to mean absolute deviations (MADs) of 1.45 and 1.87 kcal/mol, respectively. In comparison with some other functionals, MADs for HOFs are 2.31 (M06-2X), 2.98 (B2PLYP-D), 3.04 (BMK), 3.96 (B3LYP), 4.47 (B2PLYP), 5.42 (B2GP-PLYP), 6.46 (PBE0), and 29.93 kcal/mol (B3P86), and the corresponding errors for BDEs are 2.06 (M06-2X), 2.25 (BMK), 2.51 (B2PLYP-D), 2.89 (B2GP-PLYP), 3.30 (B3P86), 3.44 (B2PLYP), 3.87 (PBE0), and 6.14 kcal/mol (B3LYP). (C) 2011 Wiley Periodicals, Inc. J Comput Chem 32: 1824-1838, 2011
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