| 1. |
- Fu, H. S., et al.
(author)
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First Measurements of Electrons and Waves inside an Electrostatic Solitary Wave
- 2020
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In: Physical Review Letters. - : AMER PHYSICAL SOC. - 0031-9007 .- 1079-7114. ; 124:9
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Journal article (peer-reviewed)abstract
- Electrostatic solitary wave (ESW)-a Debye-scale structure in space plasmas-was believed to accelerate electrons. However, such a belief is still unverified in spacecraft observations, because the ESW usually moves fast in spacecraft frame and its interior has never been directly explored. Here, we report the first measurements of an ESW's interior, by the Magnetospheric Multiscale mission located in a magnetotail reconnection jet. We find that this ESW has a parallel scale of 5 lambda(De) (Debye length), a superslow speed (99 km/s) in spacecraft frame, a longtime duration (250 ms), and a potential drop e phi(0)/kT(e) similar to 5%. Inside the ESW, surprisingly, there is no electron acceleration, no clear change of electron distribution functions, but there exist strong electrostatic electron cyclotron waves. Our observations challenge the conventional belief that ESWs are efficient at particle acceleration.
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| 2. |
- Liu, Chunxin, 1991-, et al.
(author)
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Cross-scale Dynamics Driven by Plasma Jet Braking in Space
- 2022
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In: Astrophysical Journal. - : American Astronomical Society. - 0004-637X .- 1538-4357. ; 926:2
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Journal article (peer-reviewed)abstract
- Plasma jets are ubiquitous in space. In geospace, jets can be generated by magnetic reconnection. These reconnection jets, typically at fluid scale, brake in the near-Earth region, dissipate their energies, and drive plasma dynamics at kinetic scales, generating field-aligned currents that are crucial to magnetospheric dynamics. Understanding of the cross-scale dynamics is fundamentally important, but observation of coupling among phenomena at various scales is highly challenging. Here we report, using unprecedentedly high-cadence data from NASA's Magnetospheric Multiscale Mission, the first observation of cross-scale dynamics driven by jet braking in geospace. We find that jet braking causes MHD-scale distortion of magnetic field lines and development of an ion-scale jet front that hosts strong Hall electric fields. Parallel electric fields arising from the ion-scale Hall potential generate intense electron-scale field-aligned currents, which drive strong Debye-scale turbulence. Debye-scale waves conversely limit intensity of the field-aligned currents, thereby coupling back to the large-scale dynamics. Our study can help in understanding how energy deposited in large-scale structures is transferred into small-scale structures in space.
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| 3. |
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| 4. |
- Ahluwalia, T. S., et al.
(author)
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Genome-wide association study of circulating interleukin 6 levels identifies novel loci
- 2021
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In: Human molecular genetics. - : Oxford University Press (OUP). - 0964-6906 .- 1460-2083. ; 30:5, s. 393-409
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Journal article (peer-reviewed)abstract
- Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67428 (n(discovery)=52654 and n(replication)=14774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (P-combined=1.8x10(-11)), HLA-DRB1/DRB5 rs660895 on Chr6p21 (P-combined=1.5x10(-10)) in the combined meta-analyses of all samples. We also replicated the IL6R rs4537545 locus on Chr1q21 (P-combined=1.2x10(-122)). Our study identifies novel loci for circulating IL-6 levels uncovering new immunological and inflammatory pathways that may influence IL-6 pathobiology.
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| 5. |
- Alström, Per, Professor, et al.
(author)
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Morphology, vocalizations, and mitochondrial DNA suggest that the Graceful Prinia is two species
- 2021
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In: Ornithology. - : Oxford University Press (OUP). - 0004-8038 .- 2732-4613 .- 1938-4254. ; 138:2
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Journal article (peer-reviewed)abstract
- Prinias (Cisticolidae:Prinia) are resident warblers of open areas across Africa and Asia and include many polytypic species whose species limits have not been seriously reevaluated recently. Based on an integrative taxonomic analysis of morphology, song, and mitochondrial DNA (mtDNA), we suggest that 2 species should be recognized in the Graceful Prinia (Prinia gracilis) complex. In addition, our morphological analyses show the existence of a well-marked undescribed form in southeastern Somalia, which we name herein as a new subspecies. Prinia gracilisis a small, drab, long-tailed species with streaking above and plain pale underparts that has been suggested to fall into 2 groups: the southwestern nominate group (from Egypt to Oman) and the northeastern lepida group (from Turkey through India). However, the characters presented to justify this grouping are variable and show a mosaic pattern, and whether genetic and vocal differences exist is unknown. We found consistent between-group song differences, with the nominate group giving consistently longer inter-phrase intervals, whereas the members of the lepida group sing an essentially continuous reel. An mtDNA tree suggests a deep split between the nominate and lepida groups, with a coalescence time between these clades of similar to 2.2 million years ago. Vocal and mtDNA analyses provided evidence that the northeastern Arabian Peninsula taxon carpenteri belongs to the lepida group. We found that, of all the morphological characters proposed, only proportions and tail barring and spotting relatively consistently distinguish the 2 groups. However, these characters strongly suggest that the eastern Arabian Peninsula is populated by taxa of both the gracilis and lepida groups, in different areas, but we lack genetic and bioacoustic data to corroborate this. Although further study is needed in potential contact zones, we suggest that 2 species should be recognized in the P. gracilis complex, and we propose the retention of the English name Graceful Prinia for P. gracilis sensu stricto, while we suggest that P. lepida be known as Delicate Prinia.
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| 6. |
- Benbrik, R., et al.
(author)
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Signatures of vector-like top partners decaying into new neutral scalar or pseudoscalar bosons
- 2020
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In: Journal of High Energy Physics. - : Springer Nature. - 1029-8479 .- 1126-6708. ; 2020:5
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Journal article (peer-reviewed)abstract
- We explore the phenomenology of models containing one Vector-Like Quark (VLQ), t′, which can decay into the Standard Model (SM) top quark, t, and a new spin-0 neutral boson, S, the latter being either a scalar or pseudoscalar state. We parametrise the underlying interactions in terms of a simplified model which enables us to capture possible Beyond the SM (BSM) scenarios. We discuss in particular three such scenarios: one where the SM state is supplemented by an additional scalar, one which builds upon a 2-Higgs Doublet Model (2HDM) framework and another which realises a Composite Higgs Model (CHM) through partial compositeness. Such exotic decays of the t′ can be competitive with decays into SM particles, leading to new possible discovery channels at the Large Hadron Collider (LHC). Assuming t′ pair production via strong interactions, we design signal regions optimised for one t′ → S t transition (while being inclusive on the other t¯ ′ decay, and vice versa), followed by the decay of S into the two very clean experimental signatures S → γ γ and S → Z (→ ℓ+ℓ−)γ. We perform a dedicated signal- to-background analysis in both channels, by using Monte Carlo (MC) event simulations modelling the dynamics from the proton-proton to the detector level. Under the assumption of BR(t′ → S t) = 100%, we are therefore able to realistically quantify the sensitivity of the LHC to both the t′ and S masses, assuming both current and foreseen luminosities. This approach paves the way for the LHC experiments to surpass current VLQ search strategies based solely on t′ decays into SM bosons (W±, Z , h). © 2020, The Author(s).
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| 7. |
- Feng, HL, et al.
(author)
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Associations of timing of physical activity with all-cause and cause-specific mortality in a prospective cohort study
- 2023
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In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 14:1, s. 930-
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Journal article (peer-reviewed)abstract
- There is a growing interest in the role of timing of daily behaviors in improving health. However, little is known about the optimal timing of physical activity to maximize health benefits. We perform a cohort study of 92,139 UK Biobank participants with valid accelerometer data and all-cause and cause-specific mortality outcomes, comprising over 7 years of median follow-up (638,825 person-years). Moderate-to-vigorous intensity physical activity (MVPA) at any time of day is associated with lower risks for all-cause, cardiovascular disease, and cancer mortality. In addition, compared with morning group (>50% of daily MVPA during 05:00-11:00), midday-afternoon (11:00-17:00) and mixed MVPA timing groups, but not evening group (17:00-24:00), have lower risks of all-cause and cardiovascular disease mortality. These protective associations are more pronounced among the elderly, males, less physically active participants, or those with preexisting cardiovascular diseases. Here, we show that MVPA timing may have the potential to improve public health.
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| 8. |
- Hwang, K-J, et al.
(author)
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Magnetic Reconnection Inside a Flux Rope Induced by Kelvin-Helmholtz Vortices
- 2020
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In: Journal of Geophysical Research - Space Physics. - 2169-9380 .- 2169-9402. ; 125:4
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Journal article (peer-reviewed)abstract
- On 5 May 2017, MMS observed a crater-type flux rope on the dawnside tailward magnetopause with fluctuations. The boundary-normal analysis shows that the fluctuations can be attributed to nonlinear Kelvin-Helmholtz (KH) waves. Reconnection signatures such as flow reversals and Joule dissipation were identified at the leading and trailing edges of the flux rope. In particular, strong northward electron jets observed at the trailing edge indicated midlatitude reconnection associated with the 3-D structure of the KH vortex. The scale size of the flux rope, together with reconnection signatures, strongly supports the interpretation that the flux rope was generated locally by KH vortex-induced reconnection. The center of the flux rope also displayed signatures of guide-field reconnection (out-of-plane electron jets, parallel electron heating, and Joule dissipation). These signatures indicate that an interface between two interlinked flux tubes was undergoing interaction, causing a local magnetic depression, resulting in an M-shaped crater flux rope, as supported by reconstruction.
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| 9. |
- Hyde, K. D., et al.
(author)
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Global consortium for the classification of fungi and fungus-like taxa
- 2023
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In: MYCOSPHERE. - : Mushroom Research Foundation. - 2077-7000 .- 2077-7019. ; 14:1, s. 1960-2012
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Journal article (peer-reviewed)abstract
- The Global Consortium for the Classification of Fungi and fungus-like taxa is an international initiative of more than 550 mycologists to develop an electronic structure for the classification of these organisms. The members of the Consortium originate from 55 countries/regions worldwide, from a wide range of disciplines, and include senior, mid-career and early-career mycologists and plant pathologists. The Consortium will publish a biannual update of the Outline of Fungi and fungus-like taxa, to act as an international scheme for other scientists. Notes on all newly published taxa at or above the level of species will be prepared and published online on the Outline of Fungi website (https://www.outlineoffungi.org/), and these will be finally published in the biannual edition of the Outline of Fungi and fungus-like taxa. Comments on recent important taxonomic opinions on controversial topics will be included in the biannual outline. For example, 'to promote a more stable taxonomy in Fusarium given the divergences over its generic delimitation', or 'are there too many genera in the Boletales?' and even more importantly, 'what should be done with the tremendously diverse 'dark fungal taxa?' There are undeniable differences in mycologists' perceptions and opinions regarding species classification as well as the establishment of new species. Given the pluralistic nature of fungal taxonomy and its implications for species concepts and the nature of species, this consortium aims to provide a platform to better refine and stabilise fungal classification, taking into consideration views from different parties. In the future, a confidential voting system will be set up to gauge the opinions of all mycologists in the Consortium on important topics. The results of such surveys will be presented to the International Commission on the Taxonomy of Fungi (ICTF) and the Nomenclature Committee for Fungi (NCF) with opinions and percentages of votes for and against. Criticisms based on scientific evidence with regards to nomenclature, classifications, and taxonomic concepts will be welcomed, and any recommendations on specific taxonomic issues will also be encouraged; however, we will encourage professionally and ethically responsible criticisms of others' work. This biannual ongoing project will provide an outlet for advances in various topics of fungal classification, nomenclature, and taxonomic concepts and lead to a community-agreed classification scheme for the fungi and fungus-like taxa. Interested parties should contact the lead author if they would like to be involved in future outlines.
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| 10. |
- Jia, TY, et al.
(author)
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Epigenome-wide meta-analysis of blood DNA methylation and its association with subcortical volumes: findings from the ENIGMA Epigenetics Working Group
- 2021
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In: Molecular psychiatry. - : Springer Science and Business Media LLC. - 1476-5578 .- 1359-4184. ; 26:8, s. 3884-3895
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Journal article (peer-reviewed)abstract
- DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as a peripheral marker for the brain. Here, in an analysis of eleven international cohorts, totalling 3337 individuals, we report epigenome-wide meta-analyses of blood DNA methylation with volumes of the hippocampus, thalamus and nucleus accumbens (NAcc)—three subcortical regions selected for their associations with disease and heritability and volumetric variability. Analyses of individual CpGs revealed genome-wide significant associations with hippocampal volume at two loci. No significant associations were found for analyses of thalamus and nucleus accumbens volumes. Cluster-based analyses revealed additional differentially methylated regions (DMRs) associated with hippocampal volume. DNA methylation at these loci affected expression of proximal genes involved in learning and memory, stem cell maintenance and differentiation, fatty acid metabolism and type-2 diabetes. These DNA methylation marks, their interaction with genetic variants and their impact on gene expression offer new insights into the relationship between epigenetic variation and brain structure and may provide the basis for biomarker discovery in neurodegeneration and neuropsychiatric conditions.
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