| 1. |
|
|
| 2. |
|
|
| 3. |
- Ekström, Per A R, et al.
(author)
-
Impaired nerve regeneration in streptozotocin-diabetic rats. Effects of treatment with an aldose reductase inhibitor
- 1989
-
In: Journal of the Neurological Sciences. - 0022-510X. ; 93:2-3, s. 231-237
-
Research review (peer-reviewed)abstract
- Rats with streptozotocin-induced diabetes have a decreased rate of sciatic nerve regeneration. We studied the effects on this defect of treatment with the aldose reductase inhibitor, ponalrestat (25 mg/kg per day via an endogastric tube). The nerves of diabetic rats were crush-injured at 5 weeks of diabetes and regeneration evaluated 7 days later with the pinch-reflex test. Ponalrestat treatment was started at day 3 after streptozotocin injection and was continued for the whole experimental period, i.e. until 6 weeks of diabetes. The treatment prevented effectively the accumulation of sorbitol and fructose in the nerves of diabetic rats, but was without effect on the sciatic nerve regeneration (controls 21.8 ± 1.2 mm/7 days (mean ± SEM, n = 6), untreated diabetics 15.8 ± 1.8 (n = 7), ponalrestat-treated diabetics 16.2 ± 1.0 (n = 10)). The results indicate that there is no connection between increased sorbitol pathway flux and impaired regeneration in streptozotocin diabetic rats.
|
|
| 4. |
- Malmgren, Helge, 1945, et al.
(author)
-
Selective attention is selective learning.
- 1989
-
In: Göteborg Psychological Reports. - 0301-0996. ; 19:2
-
Journal article (other academic/artistic)abstract
- In this paper we model bottom-up induced selective attention as a redistribution of learning ability in a system of neurons, and present some simulations to illustrate the concept.
|
|
| 5. |
- Gabrielsson, Britt, 1957, et al.
(author)
-
Effects of divalent metal ions on the uptake of glutamate and GABA from synaptosomal fractions
- 1986
-
In: Brain Research. - 0006-8993. ; 384:2, s. 218-23
-
Journal article (peer-reviewed)abstract
- The effects of divalent metal ions on high affinity uptake glutamate and GABA were examined, using crude and purified synaptosomal fractions prepared from brains of DBA/2CBI. The uptake velocities of both amino acids are severely reduced in the presence of Cu2+, Fe2+ and Zn2+ but remain unaffected by Co2+.
|
|
| 6. |
|
|
| 7. |
|
|
| 8. |
- Ekström, Per A R, et al.
(author)
-
Nerve regeneration and serum levels of insulin-like growth factor-I in rats with streptozotocin-induced insulin deficiency
- 1989
-
In: Brain Research. - : Elsevier BV. - 0006-8993. ; 496:1-2, s. 141-147
-
Journal article (peer-reviewed)abstract
- Peripheral nerve regeneration was studied in female Sprague-Dawley rats with streptozotocin-induced insulin deficiency. Nerve regeneration was provoked by a crush lesion on the sciatic nerve 21 days after the streptozotocin injection. The regeneration was assessed by a pinch test at different time-points after injury. The rate ofregeneration in insulin-deficient animals, 2.5 mm/day, was significantly lower than in control animals, 2.9 mm/day(P < 0.05). There was no difference in the initial delay, i.e. the period before regeneration attains a constant velocity. One group of insulin-deficient rats was treated with insulin during the regeneration period by means of implanted osmotic mini-pumps. This treatment prevented the decrease in regenerationsw. After 6 days the sciatic nerves of insulin-deficient rats had regenerated 12.3 ±0.3 mm (mean ±S.E.M.), while the corresponding value for insulin-treated rats was 15.7 ±0.6 mm (P > 0.01). The streptozotocin-treated rats were found to have a 39% reduction in the serum level of insulin-like 1 growth factor-I (IGF-I)_compared to control rats (0.33 ± 0.22 μg/ml and 0.54 ± ml respectively, (P < 0.001). Insulin treatment 1830 1732 during the regeneration period completely restored the IGF-I level back to normal.
|
|
| 9. |
|
|
| 10. |
- Hansson, H A, et al.
(author)
-
Evidence indicating trophic importance of IGF-I in regenerating peripheral nerves
- 1986
-
In: Acta Physiologica Scandinavica. - : Wiley. - 0001-6772 .- 1365-201X. ; 126:4, s. 14-609
-
Journal article (peer-reviewed)abstract
- The mechanisms influencing regeneration of peripheral nerves are incompletely known, but growth factors are supposed to play a key role. In the present study, we demonstrate, with the aid of immunohistochemical methods, that somatomedin C (Sm-C/insulin-like growth factor I/IGF-I) rapidly increased from low to high concentrations, reaching peak values in 2 weeks, in regenerating sciatic nerves of adult rats. In addition, IGF-I was demonstrated extracellularly, never observed in the control nerves. Reactive Schwann cells appeared to be the major source for IGF-synthesis. Higher concentrations were seen in tubulated nerves as compared to sutured ones. It is proposed that IGF-I exerts important growth supporting effects on regenerating peripheral nerves.
|
|
