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| 2. |
- Alling, Christer, et al.
(author)
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Anionic glycerophospholipids in platelets from alcoholics
- 1986
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In: Drug and Alcohol Dependence. - : Elsevier BV. - 1879-0046 .- 0376-8716. ; 16:4, s. 309-320
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Journal article (peer-reviewed)abstract
- Studies on ethanol-exposed animals have revealed changes in anionic phospholipids in brain membranes. The intention of this study was to investigate whether there was a similar effect on man. Assuming platelets to be an adequate model for CNS synaptosomes, concentration and fatty acid composition of anionic phospholipids, phosphatidylserine (PS) and phosphatidylositol (PI) in the platelet membrane from alcoholics after a debauche period were examined and compared to controls. Ethanol effects on neutral lipids were also analysed in order to obtain a comprehensive view. No quantitative difference was found in anionic phospholipids between alcoholics and controls. Fatty acid composition of individual phospholipids revealed significant changes which were more obvious in neutral phospholipids than in anionic. Oleic acid was increased and linoleic and arachidonic acids were decreased. After 1 week of detoxification, the abnormalities did not decrease, on the contrary they increased and total phospholipid concentration per platelet was significantly higher than in controls. It is concluded that the ethanol toxicity on bone marrow hampers the use of platelets as a model for synaptosomes but that the observed lipid abnormalities might play a major role in the impairment of platelet function in alcoholics.
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| 3. |
- Simonsson, Per, et al.
(author)
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Ethanol effects on bradykinin-stimulated phosphoinositide hydrolysis in NG 108-15 neuroblastoma-glioma cells
- 1989
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In: Alcohol. - : Elsevier BV. - 0741-8329. ; 6:6, s. 475-479
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Journal article (peer-reviewed)abstract
- The effect of short-and long-term ethanol exposure on bradykinin-stimulated hydrolysis of phosphatidylinositol 4.5-bisphosphate (PIP2) was investigated in neuroblastoma X glioma hybrid cells (NG 108-15). Acute exposure of 50-150 mM ethanol neither influenced the bradykinin-stimulated accumulation of [3H]-inositol phosphates (IP1, IP2, IP3) nor the hydrolysis of PIP2 in cells labelled with [3H]-inositol. Furthermore, ethanol (100 mM) added in the absence of agonist did not influence these parameters. However, in cells cultivated for 4 days in 100 mM ethanol, PIP2 hydrolysis and IP1, IP2 and IP3 formation after stimulation by 10(-6)-10(-5) M bradykinin was markedly inhibited while there was no effect on the basal levels or on the levels found after stimulation with low concentrations of bradykinin. The inhibitory effect of ethanol on IP accumulation became significant after 2-3 days of ethanol.
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| 4. |
- Simonsson, Per, et al.
(author)
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Ethanol stimulates basal and serotonin-induced formation of [32P]phosphatidic acid in human platelets
- 1989
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In: Drug and Alcohol Dependence. - : Elsevier BV. - 1879-0046 .- 0376-8716. ; 24:2, s. 169-174
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Journal article (peer-reviewed)abstract
- The addition of serotonin to preparations of 32P-labelled human platelets resulted in a time- and dose-dependent hydrolysis of [32P]phosphatidylinositol 4,5-bisphosphate (PIP2) and formation of [32P]phosphatidic acid (PA). This response was inhibited by the serotonin2 receptor antagonist ritanserin, indicating that the stimulation was mediated via the serotonin2 receptor. The addition of 50-150 mM of ethanol prior to stimulation with 10(-5) M serotonin resulted in an increased accumulation of [32P]PA, but had no effect on [32P]PIP2. Ethanol stimulated [32P]PA formation at all serotonin concentrations studied (10(-7)-10(-5) M). Furthermore, in the absence of serotonin, ethanol increased basal [32P]PA formation.
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| 5. |
- Simonsson, Per, et al.
(author)
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Protein kinase C modulation of the ethanol effect on serotonin2 receptor transduction in astrocytes
- 1989
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In: Alcohol and Alcoholism. - 1464-3502. ; 24:5, s. 401-404
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Journal article (peer-reviewed)abstract
- Acute ethanol exposure stimulated serotonin2 receptor signalling in cultured astrocytes. Pretreatment with the protein kinase C inhibitor H7 significantly increased the ethanol-induced potentiation of [3H]-inositol phosphates accumulation. The increase could be explained by an augmented activation of phospholipase C. The results indicate a role of PKC for the modulation of ethanol effects on cellular signalling.
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| 8. |
- Öjehagen, Agneta, et al.
(author)
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To keep the alcoholic in out-patient treatment. : A differentiated approach through treatment contracts
- 1986
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In: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 73:1, s. 68-75
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Journal article (peer-reviewed)abstract
- Eighty-two alcoholics were offered a 2-year out-patient programme characterized by stressing the patients' own decisions both in joining the programme and in the choice of objectives and methods, by repeated feedbacks through treatment evaluations, and by relapse prevention. The 58 patients who accepted were more often married than the others. All but eight completed the programme. The most important treatment components were ranked by the patients. Individual counselling was ranked highest, followed by evaluations of contract with therapist, disulfiram and biofeedback by means of gamma-GT. Patients with alcohol dependence more often preferred instrumental components, such as disulfiram and gamma-GT, while the others more often preferred psychological components, such as individual counselling and contract evaluations. Preference of psychological components was not found to be related to degree of personality disturbances. It is suggested that to effectively keep the patients in treatment in the present programme depends on the combination of patients' active engagement, continuous feedback and individualized treatment objectives.
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| 9. |
- Lindqvist, Per, 1949-
(author)
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Violence against a person : the role of mental disorder and abuse : a study of homicides and an analysis of criminality in a cohort of patients with schizophrenia
- 1989
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Doctoral thesis (other academic/artistic)abstract
- Interpersonal violence is a matter of growing concern. Where the safety of the common man is concerned, the dangerousness of mental patients, the ongoing de-institutionalization within psychiatry, and the role of alcohol is disputed. In order to analyze the significance of abuse and mental disorder in violent behaviour, this subject was approached from two different perspectives; from a specific violent offence - homicide - examining the mental status of the offenders, and from individuals with a specific mental disorder - schizophrenia -and assessing the rate of criminal offence amongst them.Homicides in northern Sweden and in Stockholm, legally characterized as murder, manslaughter or assault and causing another’s death, and homicides followed by the offenders’ suicide, were studied. Medicolegal autopsy records, police reports, pretrial psychiatric reports and court records were collected and scrutinized.The criminal records of 644 persons, discharged from hospitals in Stockholm with a diagnosis of schizophrenia, were studied. The relative risk of criminal offence was analyzed by indirect standardization using the general population as a standard. Violent offenders were further examined from psychiatric records.In the homicide material, 16 females and 160 males killed 94 men, 78 women, and 15 children. Forty percent of all surviving offenders were abusers without a major mental disorder, 39% were mentally disordered, 11% committed suicide, and 10% were considered "normal". The abusers and their victims were older, often socially and mentally deteriorated, and well known to each other. The victim was the prime aggressor in half of the cases. Killings by mentally disordered persons and by those who committed suicide were characterized by intimacy between offender and victim; one third were also abusers. Multiple homicides and child murder were mainly seen among homicide-suicice cases. The "normal" offenders were more often of foreign origin and two thirds of the victims initiated the violence by physical attacks. Relatively more of the homicides in northern Sweden concerned intimate parties, use of firearms, and cases of homicide-suicide, as compared to homicides in Stockholm where drug abuse was more prevalent. Sixteen offenders (9%) in the homicide sample had schizophrenia (all males), while 38 subjects (6%) in the cohort of schizophrenics had committed a violent offence. No homicide was recorded and most of the offences were of minor severity. The rate of violent offence was four times higher in the study group as compared to the general population.Most homicides involved closely related persons with separation and dependence as the dominating psychological theme, especially in homicide- suicide cases. Intoxication was regularly seen among the abusers but not among the non-abusers. The acute effect of alcohol intoxication may be of lesser importance in violence as compared to the long-term effects of abuse. Schizophrenics do not impress as a particularly dangerous group. Prevention by psychiatry is difficult; most offenders did not have any contact with psychiatry prior to the act.
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