| 1. |
- Asman, P, et al.
(författare)
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Evaluation of methods for automated Hemifield analysis in perimetry
- 1992
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Ingår i: Archives of Ophthalmology. - : American Medical Association (AMA). - 0003-9950. ; 110:6, s. 6-820
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Tidskriftsartikel (refereegranskat)abstract
- A new aid to perimetric analysis, the Glaucoma Hemifield Test, primarily evaluates up-down differences in automated static visual field tests. We analyzed the visual fields of 163 eyes of 163 normal subjects and 77 eyes of 77 patients with glaucoma diagnosed on bases other than perimetry using the Glaucoma Hemifield Test and a similar, previously developed, hemifield analysis method. The performance of the Glaucoma Hemifield Test was compared with that of the earlier method and the differences in test design were evaluated individually. The Glaucoma Hemifield Test allowed significantly improved separation between the normal group and the group with glaucoma than did the earlier method. This improvement was due to an increase in sensitivity, and was associated with the use of test point significances instead of threshold values, and a large normal database alone in the determination of normal limits.
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| 2. |
- Asman, P, et al.
(författare)
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Glaucoma Hemifield Test. Automated visual field evaluation
- 1992
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Ingår i: Archives of Ophthalmology. - : American Medical Association (AMA). - 0003-9950. ; 110:6, s. 9-812
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Tidskriftsartikel (refereegranskat)abstract
- We have developed an algorithm, the Glaucoma Hemifield Test (GHT), for automated evaluation of single static threshold visual field test results in glaucoma. The GHT uses empirically determined limits of normality for up-down differences in the Statpac probability maps of the Humphrey Field Analyzer to detect localized visual field loss. It is also constructed to detect field loss that is symmetric around the horizontal meridian. Analysis is done in five corresponding pairs of sectors that are based on the normal anatomy of the retinal nerve fiber layer. Deviations from the age-corrected normal threshold in the most sensitive portions of the visual field are used to detect general reductions of sensitivity or abnormally high sensitivities. The GHT provides brief visual field evaluations printed on the field chart as plain text. The aim of this article is to describe the fundamentals of the analysis program and to provide clinical examples.
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| 3. |
- Friström, Björn, et al.
(författare)
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Interaction of PhXA41, a New Prostaglandin Analogue, With Pilocarpine : A Study on Patients With Elevated Intraocular Pressure
- 1993
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Ingår i: Archives of ophthalmology (1960). - 0003-9950. ; 111:5, s. 662-665
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Tidskriftsartikel (refereegranskat)abstract
- Objective. —To evaluate the effects of PhXA41, a new prostaglandin analogue, on the intraocular pressure (IOP) in patients receiving pilocarpine treatment and the effects of pilocarpine in patients receiving PhXA41 treatment.Design. —Twenty patients with ocular hypertension were randomized into two parallel groups. The treatment period was 2 weeks. Ten patients in group 1 were given PhXA41 twice daily during week 1 and, in addition, pilocarpine three times daily during week 2. Ten patients in group 2 received pilocarpine three times daily during week 1 and PhXA41 twice daily in addition during week 2. PhXA41 was used in a concentration of 0.006%, and pilocarpine was given in a concentration of 2%.Main Outcome Measures. —In group 1, the mean IOP on day 0 was 25.1 mm Hg; on day 7,19.1 mm Hg; and on day 14,17.6 mm Hg. In group 2, the mean IOP on day 0 was 23.8 mm Hg; on day 7,20.4 mm Hg; and on day 14,17.7 mm Hg.Results. —PhXA41 had a clinically significant IOP-lowering effect (23.4% reduction on day 7 as compared with baseline day (P<.001). The corresponding value with pilocarpine was 14.3% (P<.001). When pilocarpine was added to PhXA41, the additional IOP reduction was 7.4% (P<.01) compared with 14.2% (P<.01) when PhXA41 was added to pilocarpine. The two groups were found to have an almost equal reduction in IOP on day 14 (group 1,29.4%; group 2, 26.6%). No serious adverse reactions were seen. Some conjunctival hyperemia in the PhXA41-treated eyes was noted on day 7, as compared with the pilocarpine-treated eyes, but there were few complaints of discomfort.Conclusions. —This study indicated that PhXA41 could be useful in the treatment of glaucoma, as monotherapy, or in certain cases in combination with pilocarpine.
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| 4. |
- Heijl, A, et al.
(författare)
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The effect of perimetric experience in patients with glaucoma
- 1996
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Ingår i: Archives of Ophthalmology. - 0003-9950. ; 114:1, s. 19-22
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE: To study prospectively the effects of perimetric learning in glaucoma patients.PATIENTS AND METHODS: Twenty-five patients with newly detected glaucoma underwent repeated perimetric testing using the 30-2 full threshold program with the Humphrey perimeter. Each patient was tested five times at about 1-week intervals. No patient had undergone perimetry before entering the study.RESULTS: In most patients, visual field results improved with repeated testing. Improvements were obvious in 21 of the 37 glaucomatous eyes. Means of mean deviation values improved significantly, by 2.81 dB (P < .001, analysis of variance), between the first and the second test session, and no significant differences were shown between tests 2 and 5. Fields with moderate field loss improved more than fields with milder or more severe loss. Learning effects were more pronounced peripherally than centrally, and better points improved more than more disturbed ones.CONCLUSIONS: The effects of perimetric learning were large and common, and are clinically important. Baselines for perimetric follow-up of patients with glaucoma should consist of more than one test. To avoid misleading conclusions, studies using perimetry to assess the effects of glaucoma treatment should take learning effects into consideration.
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