| 1. |
- Andersson, Maria, et al.
(author)
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Inhibition of kainic acid binding to glutamate receptors by extracts of Gastrodia
- 1995
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In: Phytochemistry. - 0031-9422. ; 38:4, s. 835-836
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Journal article (peer-reviewed)abstract
- S-(4-hydroxybenzyl)glutathione was isolated as the major principle responsible for the inhibition of the in vitro binding of kainic acid to brain glutamate receptors by water extracts of the plant Gastrodia elata. The affinity (IC50 value) of the compound is slightly lower compared to glutamate and glutathione.
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| 2. |
- Bergendorff, Ola, et al.
(author)
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Furanocoumarins with affinity to brain benzodiazepine receptors in vitro
- 1997
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In: Phytochemistry. - 0031-9422. ; 44:6, s. 1121-1124
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Journal article (peer-reviewed)abstract
- Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.
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| 3. |
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| 4. |
- Mbah, JA, et al.
(author)
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Two chromones from Peperomia vulcanica
- 2002
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In: Phytochemistry. - 0031-9422. ; 60:8, s. 799-801
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Journal article (peer-reviewed)abstract
- Two chromones: 5-hydroxy-2-(14'-(E)-nonadecenyl) chromone (1) and 5-hydroxy-2-[12'-(3",4"-methylenedioxyphenyl)dodecanyl] chromone (2), together with six known compounds have been isolated from Peperomia vulcanica Baker & C. H. Wright (Piperaceae). Their structures were determined by spectroscopic analysis including 2D NMR techniques.
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| 5. |
- Ncube, Ignatious, et al.
(author)
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Triacylglycerols of Vernonia galamensis seed oil
- 1998
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In: Phytochemistry. - 0031-9422. ; 47:5, s. 723-727
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Journal article (peer-reviewed)abstract
- Separation methods using silica gel column chromatography and preparative thin layer chromatography were employed to prepare pure triacylglycerol fractions of the oil from Vernonia galamensis seeds. Pure vernolic acid (12, 13-epoxy-octadec-cis-9-enoic acid) was prepared by enzymatic hydrolysis of the chromatographically purified major triacylglycerol, trivernolin, using a commercially available immobilised lipase in a non-polar organic solvent. Analysis of the divernoloyl and monovernoloyl triacylglycerols with porcine pancreatic lipase indicated that vernolic acid is found mainly as the secondary ester in the divernoloyl triacylglycerol but not the monovernoloyl triacylglycerol.
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| 6. |
- Nkengfack, Augustin E, et al.
(author)
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Prenylated isoflavanone from the roots of Erythrina sigmoidea
- 1994
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In: Phytochemistry. - 0031-9422. ; 36:4, s. 1047-1051
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Journal article (peer-reviewed)abstract
- A novel prenylated isoflavanone, sigmoidin I, has been isolated from the roots of Erythrina sigmoidea, in addition to the known isoflavones, corylin and neobavaisoflavone and the known pterocarpan, phaseollidin. Its structure was established as 7,4'-dihydroxy-3'-methoxy-5'-(3-methylbut-2-enyl) isoflavanone by means of spectroscopic analyses and chemical transformations. Neobavaisoflavone displayed antifungal potency in vitro with minimum inhibitory concentrations against Aspergillus fumigatus and Cryptococcus neoformans, of 50 mg ml-1.
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| 7. |
- Omolo, JO, et al.
(author)
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Hericenols A-D and a chromanone from submerged cultures of a Stereum species
- 2002
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In: Phytochemistry. - 0031-9422. ; 60:4, s. 431-435
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Journal article (peer-reviewed)abstract
- Extracts of submerged cultures of a Stereum species afforded four new pentasubstituted phenolic compounds, named hericenols A, B, C, and D (1-4), 6-hydroxymethyl-2,2-dimethylchroman-4-one (5) and the known erinapyrone C. Hericenol A (1) showed weak antimicrobial activity while hericenol C (3) was weakly cytotoxic. The structures of the metabolites were determined by spectroscopic techniques. (C) 2002 Elsevier Science Ltd. All rights reserved.
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| 8. |
- Pistelli, L, et al.
(author)
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Pterocarpans from Bituminaria bituminosa and Bituminaria morisiana.
- 2003
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In: Phytochemistry. - 0031-9422. ; 64:2, s. 595-598
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Journal article (peer-reviewed)abstract
- The aerial parts of Mediterranean papilionaceous plants Bituminaria morisiana and B. bituminosa afforded, along with known phenolics, the prenylated pterocarpans bitucarpin A and B, whose structure was elucidated by spectroscopic techniques. A known isoflavonoid (8-prenyldaidzein) was also obtained for the first time as a genuine plant constituent. The accumulation of pterocarpans at the expense of biogenetically more primitive shikimate metabolites like furanocoumarins or isoflavonoids supports the inclusion of this plant, once part of the genus Psoralea, into the distinct genus Bituminaria.
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| 9. |
- Silberborth, S, et al.
(author)
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Gerronemins A-F, cytotoxic biscatechols from a Gerronema species
- 2002
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In: Phytochemistry. - 0031-9422. ; 59:6, s. 643-648
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Journal article (peer-reviewed)abstract
- The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.
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| 10. |
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