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| 2. |
- Lindblom, Emely, et al.
(author)
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Accounting for Two Forms of Hypoxia for Predicting Tumour Control Probability in Radiotherapy : An In Silico Study
- 2018
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In: Advances in Experimental Medicine and Biology. - Cham : Springer International Publishing. - 0065-2598 .- 2214-8019. ; 1042, s. 183-187
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Journal article (peer-reviewed)abstract
- The progress in functional imaging and dose delivery has opened the possibility of targeting tumour hypoxia with radiotherapy. Advanced approaches apply quantitative information on tumour oxygenation retrieved from imaging in dose prescription. These do not, however, take into account the potential difference in radiosensitivity of chronically and acutely hypoxic cells. It was the aim of this study to evaluate the implications of assuming the same or different sensitivities for the hypoxic cells. An in silico 3D-model of a hypoxic tumour with heterogeneous oxygenation was used to model the probabilities of tumour control with different radiotherapy regimens. The results show that by taking into account the potential lower radioresistance of chronically hypoxic cells deprived of oxygen and nutrients, the total dose required to achieve a certain level of control is substantially reduced for a given fractionation scheme in comparison to the case when chronically and acutely hypoxic cells are assumed to have similar features. The results also suggest that the presence of chronic hypoxia could explain the success of radiotherapy for some hypoxic tumours. Given the implications for clinical dose escalation trials, further exploration of the influence of the different forms of hypoxia on treatment outcome is therefore warranted.
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| 3. |
- Abdulreda, MH, et al.
(author)
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The Different Faces of the Pancreatic Islet
- 2016
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In: Advances in experimental medicine and biology. - Cham : Springer International Publishing. - 0065-2598. ; 938, s. 11-24
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Journal article (peer-reviewed)
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| 4. |
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| 5. |
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| 6. |
- Ackermann, PW, et al.
(author)
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Tendon Innervation
- 2016
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In: Advances in experimental medicine and biology. - Cham : Springer International Publishing. - 0065-2598. ; 920, s. 35-51
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Journal article (peer-reviewed)
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| 7. |
- Ahmed, AS, et al.
(author)
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Does Diabetes Mellitus Affect Tendon Healing?
- 2016
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In: Advances in experimental medicine and biology. - Cham : Springer International Publishing. - 0065-2598. ; 920, s. 179-184
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Journal article (peer-reviewed)
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| 8. |
- Akcakaya, P, et al.
(author)
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MicroRNAs and Gastrointestinal Stromal Tumor
- 2015
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In: Advances in experimental medicine and biology. - Cham : Springer International Publishing. - 0065-2598. ; 889, s. 51-70
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Journal article (peer-reviewed)
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| 9. |
- Akhade, Vijay Suresh, et al.
(author)
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Long Noncoding RNA: Genome organization and mechanism of action
- 2017
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In: Long Non Coding RNA Biology. M.R.S. Rao (red.). - Singapore : Springer. - 0065-2598. - 9789811052026 ; , s. 47-74
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Book chapter (other academic/artistic)abstract
- For the last four decades, we have known that noncoding RNAs maintain critical housekeeping functions such as transcription, RNA processing, and translation. However, in the late 1990s and early 2000s, the advent of high-throughput sequencing technologies and computational tools to analyze these large sequencing datasets facilitated the discovery of thousands of small and long noncoding RNAs (lncRNAs) and their functional role in diverse biological functions. For example, lncRNAs have been shown to regulate dosage compensation, genomic imprinting, pluripotency, cell differentiation and development, immune response, etc. Here we review how lncRNAs bring about such copious functions by employing diverse mechanisms such as translational inhibition, mRNA degradation, RNA decoys, facilitating recruitment of chromatin modifiers, regulation of protein activity, regulating the availability of miRNAs by sponging mechanism, etc. In addition, we provide a detailed account of different mechanisms as well as general principles by which lncRNAs organize functionally different nuclear sub-compartments and their impact on nuclear architecture. © 2017, Springer Nature Singapore Pte Ltd.
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