SwePub
Sök i SwePub databas

  Extended search

Träfflista för sökning "L773:0165 5728 "

Search: L773:0165 5728

  • Result 1-10 of 361
Sort/group result
   
EnumerationReferenceCoverFind
1.
  •  
2.
  •  
3.
  •  
4.
  •  
5.
  •  
6.
  •  
7.
  • Bracci-Laudiero, Luisa, et al. (author)
  • NGF modulates CGRP synthesis in human B-lymphocytes : A possible anti-inflammatory action of NGF?
  • 2002
  • In: Journal of Neuroimmunology. - 0165-5728 .- 1872-8421. ; 123:1-2, s. 58-65
  • Journal article (peer-reviewed)abstract
    • We investigated whether the sensory neuropeptide, calcitonin gene-related peptide (CGRP), could be synthesised by human lymphocytes. Our results indicate that in activated B-cells, there is a strong expression of CGRP gene transcripts, which is almost absent in resting cells. Since B-cells autocrinally produce NGF, the neutralisation of endogenous NGF by anti-NGF antibodies resulted in a marked reduction in CGRP expression in both resting and activated B-cells. Thus, NGF appears to directly affect the synthesis of CGRP in B-cells as in sensory neurons. By regulating CGRP synthesis in lymphocytes and neuronal cells, NGF can influence the intensity and duration of the immune response. ⌐ 2002 Elsevier Science B.V. All rights reserved.
  •  
8.
  • Dahle, Charlotte, et al. (author)
  • T lymphocyte subset abnormalities in peripheral blood from patients with the Guillain-Barré syndrome
  • 1994
  • In: Journal of Neuroimmunology. - : Elsevier BV. - 0165-5728 .- 1872-8421. ; 53:2, s. 219-225
  • Journal article (peer-reviewed)abstract
    • T lymphocytes are probably of pathogenic importance in many autoimmune diseases. Recently, deviations of circulating T-helper (CD4+) subpopulations have been noticed. Blood samples from 12 patients with Guillain-Barré syndrome (GBS) were studied with flow cytometry during their disease to define circulating T cell populations. The proportion of T-helper cells (CD4+) was decreased (mean value 41±15%, P = 0.01) and the proportion of T cytotoxic/suppressor cells (CD8+) was increased (35±18%, P = 0.0006) as compared to the control group of healthy blood donors (47±8% and 26±7% respectively). The CD4+ population is divided into the helper/inducer (CD4+ CD29+) and suppressor/inducer (CD4+ CD45RA+) subsets. which normally are equally distributed (mean values in our control group were 45±15% and 44±15%, respectively). In patients with GBS, the helper/inducer (CD4+ CD29+) subset was increased (54±10%, P = 0.05) and the suppressor/inducer (CD4+ CD45RA+) subset was decreased (31±9, P = 0.005) compared to the controls. The proportion of activated HLA-DR-expressing T cells was increased (7±8%, P = 0.005) as compared to control (3±3%). The total proportions of T cells (CD2+), B cells (CD19+) and natural killer (NK) cells (CD56+) were similar in pateints and controls. The CD4+ and CD8+ populations, as well as the activated HLA-DR+ T cells, normalized during the disease course. The derivations within the CD4+ population also tended to normalize, but even at follow up after 6–33 (mean 23) months, some abnormalities remained. In conclusion, we confirm previous reports of T cell activation in peripheral blood from patients with GBS. A new finding is the derivation of T helper subpopulations with an increased helper/inducer (CD4+ CD29+) subset and a decreased suppressor/inducer (CD4+ CD45RA+) subset, which indicates a possible autoimmune character of GBS.
  •  
9.
  •  
10.
  •  
Skapa referenser, mejla, bekava och länka
  • Result 1-10 of 361
Type of publication
journal article (261)
conference paper (99)
research review (1)
Type of content
peer-reviewed (252)
other academic/artistic (109)
Author/Editor
Olsson, T (71)
Link, H (41)
Hillert, J (38)
Zhu, J. (30)
Jagodic, M (28)
Piehl, F (25)
show more...
Pirskanen, R (19)
Xiao, BG (19)
Huang, YM (18)
Wallstrom, E (17)
Khademi, M. (16)
Lefvert, AK (15)
Mix, E (13)
Masterman, T (13)
Zetterberg, Henrik, ... (11)
Brundin, L (11)
Winblad, B (10)
Harris, RA (10)
Lidman, O (10)
Fredrikson, S (10)
Andersson, M (10)
Diez, M (9)
Soderstrom, M (9)
Harbo, HF (8)
Blennow, Kaj, 1958 (7)
Zou, LP (7)
Kockum, I. (7)
Press, R (7)
Olsson, Tomas (7)
Dahlman, I (7)
Weissert, R (7)
Swanberg, M (7)
Levi, M (6)
He, B (6)
Al Nimer, F (6)
Bergman, P. (6)
Ljunggren, HG (6)
Lycke, Jan, 1956 (6)
Gillett, A (6)
Ruhrmann, S (6)
Akesson, E (6)
Oturai, A (6)
Ozenci, V (6)
Malmeström, Clas, 19 ... (6)
Lorentzen, JC (6)
Celius, EG (6)
Giscombe, R (6)
Imrell, K (6)
N'Diaye, M (6)
Hjelmstrom, P (6)
show less...
University
Karolinska Institutet (296)
Uppsala University (31)
University of Gothenburg (24)
Lund University (17)
Umeå University (13)
Linköping University (11)
show more...
Chalmers University of Technology (4)
Örebro University (3)
Linnaeus University (2)
Royal Institute of Technology (1)
Halmstad University (1)
Stockholm University (1)
University of Skövde (1)
Red Cross University College (1)
show less...
Language
English (360)
Swedish (1)
Research subject (UKÄ/SCB)
Medical and Health Sciences (65)
Natural sciences (1)

Year

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Close

Copy and save the link in order to return to this view